PIRP00000001	25305452	DQ590031	piR-hsa-20284	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ590031 may correlated with the increased risk of Bladder carcinoma.
PIRP00000002	25305452	DQ593431	piR-hsa-23679	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ593431 may correlated with the increased risk of Bladder carcinoma.
PIRP00000003	25998508	piR-34434	piR-hsa-26584	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-34434 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000004	25305452	DQ590335	piR-hsa-20559	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ590335 may correlated with the increased risk of Bladder carcinoma.
PIRP00000005	28654860	piR-hsa-10501	piR-hsa-10501	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-10501 may correlated with the increased risk of Alzheimer's disease.
PIRP00000006	27429044	hsa_piR_019368	piR-hsa-26819	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_019368 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000007	25305452	DQ575689	piR-hsa-5967	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ575689 may correlated with the increased risk of Bladder carcinoma.
PIRP00000008	27323410	piR-61298	piR-hsa-25447	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-61298 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000009	27429044	hsa_piR_021214	piR-hsa-29114	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_021214 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000010	25305452	DQ599177	piR-hsa-29448	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ599177 may correlated with the increased risk of Bladder carcinoma.
PIRP00000011	25305452	DQ590181	piR-hsa-20405	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ590181 may correlated with the increased risk of Bladder carcinoma.
PIRP00000012	25305452	DQ584405	piR-hsa-14730	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ584405 may correlated with the increased risk of Bladder carcinoma.
PIRP00000013	25305452	DQ596854	piR-hsa-27056	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ596854 may correlated with the increased risk of Bladder carcinoma.
PIRP00000014	28654860	piR-hsa-14547	piR-hsa-14547	Alzheimer's disease	EFO:0000249	downregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-hsa-14547 may correlated with the increased risk of Alzheimer's disease.
PIRP00000015	28654860	piR-hsa-25985	piR-hsa-25985	Alzheimer's disease	EFO:0000249	downregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-hsa-25985 may correlated with the increased risk of Alzheimer's disease.
PIRP00000016	25305452	DQ575036	piR-hsa-5342	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ575036 may correlated with the increased risk of Bladder carcinoma.
PIRP00000017	25305452	DQ574995	piR-hsa-5301	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ574995 may correlated with the increased risk of Bladder carcinoma.
PIRP00000018	25305452	DQ589358	piR-hsa-19640	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ589358 may correlated with the increased risk of Bladder carcinoma.
PIRP00000019	27323410	piR-35855	piR-hsa-28019	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-35855 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000020	25998508	piR-54436	piR-hsa-17615	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-54436 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000021	28654860	piR-hsa-27438	piR-hsa-27438	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-27438 may correlated with the increased risk of Alzheimer's disease.
PIRP00000022	25305452	DQ586998	piR-hsa-17304	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ586998 may correlated with the increased risk of Bladder carcinoma.
PIRP00000023	28651359	DQ592969	piR-hsa-23247	Diminished ovarian reserve	EFO:0004770	upregulation	increased risk	patients with diminished ovarian reserve	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Diminished ovarian reserve was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ592969 may correlated with the increased risk of Diminished ovarian reserve.
PIRP00000024	27068805	piR-31068	piR-hsa-1207	Azoospermia	EFO:0000279	downregulation	increased risk	seminal plasma of infertile patients	N/A	N/A	N/A	-0.2	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of piR-31068 may correlated with the increased risk of Azoospermia. Moreover, the molecular functions or physiological functions of piR-31068 involving in the pathologies of Azoospermia are illustrated in cell lines in vitro. Altogether, all above results suggested that the downregulation of piR-31068 is possibly correlated with the increased risk of Azoospermia.
PIRP00000025	25998508	piR-32051	piR-hsa-12178	Renal cell carcinoma	EFO:0000681	upregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	0.20	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Renal cell carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-32051 may correlated with the increased risk and poor progonosis of Renal cell carcinoma. Moreover, the molecular functions or physiological functions of piR-32051 involving in the pathologies of Renal cell carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-32051 is possibly correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000026	29516567	piR-38581	piR-hsa-30715	Neuroblastoma	EFO:0000621	upregulation	increased risk	neuroblastoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Neuroblastoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-38581 may correlated with the increased risk of Neuroblastoma.
PIRP00000027	28654860	piR-hsa-21636	piR-hsa-21636	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-21636 may correlated with the increased risk of Alzheimer's disease.
PIRP00000028	28654860	piR-hsa-4300	piR-hsa-4300	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-4300 may correlated with the increased risk of Alzheimer's disease.
PIRP00000029	25305452	DQ575105	piR-hsa-5411	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ575105 may correlated with the increased risk of Bladder carcinoma.
PIRP00000030	25305452	DQ600938	piR-hsa-31224	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ600938 may correlated with the increased risk of Bladder carcinoma.
PIRP00000031	29460056	DQ570507	piR-hsa-787	Azoospermia	EFO:0000279	downregulation	increased risk	patients with nonobstructive azoospermia (NOA) between successful and unsuccessful sperm retrieval before micro-dissection testicular sperm extraction (micro-TESE)	N/A	N/A	Cell apoptosis, cell proliferation, and cell differentiation	-0.1	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of DQ570507 may correlated with the increased risk of Azoospermia.
PIRP00000032	25305452	DQ585043	piR-hsa-15354	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ585043 may correlated with the increased risk of Bladder carcinoma.
PIRP00000033	25305452	DQ600288	piR-hsa-30488	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ600288 may correlated with the increased risk of Bladder carcinoma.
PIRP00000034	21616063	piR-651	piR-hsa-1077	Colon carcinoma	EFO:1001950	upregulation	increased risk	colon cancer tissues	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Colon carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Colon carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-651 may correlated with the increased risk of Colon carcinoma.
PIRP00000035	27429044	hsa_piR_010894	piR-hsa-15023	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_010894 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000036	25305452	DQ600289	piR-hsa-30489	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ600289 may correlated with the increased risk of Bladder carcinoma.
PIRP00000037	25305452	DQ595292	piR-hsa-25553	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ595292 may correlated with the increased risk of Bladder carcinoma.
PIRP00000038	26148798	DQ596390	piR-hsa-26606	Asthma	EFO:0000270	downregulation	increased risk	asthmatic patientss	N/A	N/A	Akt signaling pathway	-0.1	The piRNAs dysregulation associated with Asthma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Asthma was validated by RT-PCR. The validated results indicated that the downregulation of DQ596390 may correlated with the increased risk of Asthma.
PIRP00000039	25305452	DQ599906	piR-hsa-30134	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ599906 may correlated with the increased risk of Bladder carcinoma.
PIRP00000040	28423657	piR-52200	piR-hsa-15399	Breast carcinoma	EFO:0000305	upregulation	increased risk	breast cancer cell lines	N/A	N/A	AMPK signaling pathway	0.05	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-52200 may correlated with the increased risk of Breast carcinoma.
PIRP00000040	28423657	piR-52200	piR-hsa-15399	Lung carcinoma	EFO:0001071	upregulation	increased risk	lung cancer patients and lung cancer cell lines	N/A	AMPK	AMPK signaling pathway	0.40	The piRNAs dysregulation associated with Lung carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-52200 may correlated with the increased risk of Lung carcinoma. Moreover, both molecular functions and physiological functions of piR-52200 involving in the pathologies of Lung carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-52200 is possibly correlated with the increased risk of Lung carcinoma.
PIRP00000041	27323410	piR-33510	piR-hsa-22905	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-33510 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000042	25305452	DQ587911	piR-hsa-18158	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ587911 may correlated with the increased risk of Bladder carcinoma.
PIRP00000043	25305452	DQ599922	piR-hsa-30136	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ599922 may correlated with the increased risk of Bladder carcinoma.
PIRP00000044	25305452	DQ597651	piR-hsa-27896	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ597651 may correlated with the increased risk of Bladder carcinoma.
PIRP00000045	27323410	piR-34291	piR-hsa-26441	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-34291 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000045	27429044	hsa_piR_019102	piR-hsa-26441	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_019102 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000045	27829231	DQ596225	piR-hsa-26441	Lung adenocarcinoma	EFO:0000571	upregulation	poor progonosis	lung adenocarcinoma samples	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Lung adenocarcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung adenocarcinoma was validated by RT-PCR. The validated results indicated that the upregulation of DQ596225 may correlated with the poor progonosis of Lung adenocarcinoma.
PIRP00000046	25305452	DQ595179	piR-hsa-25440	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ595179 may correlated with the increased risk of Bladder carcinoma.
PIRP00000047	28654860	piR-hsa-6113	piR-hsa-6113	Alzheimer's disease	EFO:0000249	downregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-hsa-6113 may correlated with the increased risk of Alzheimer's disease.
PIRP00000048	25998508	piR-58594	piR-hsa-21746	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-58594 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000049	25998508	piR-58595	piR-hsa-21747	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-58595 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000050	27323410	piR-54907	piR-hsa-18071	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-54907 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000051	27323410	piR-30840	piR-hsa-993	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-30840 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000052	25305452	DQ591007	piR-hsa-21286	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ591007 may correlated with the increased risk of Bladder carcinoma.
PIRP00000053	27323410	piR-62011	piR-hsa-26131	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-62011 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000054	25305452	DQ590455	piR-hsa-20664	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ590455 may correlated with the increased risk of Bladder carcinoma.
PIRP00000055	29460056	DQ576492	piR-hsa-6740	Azoospermia	EFO:0000279	downregulation	increased risk	patients with nonobstructive azoospermia (NOA) between successful and unsuccessful sperm retrieval before micro-dissection testicular sperm extraction (micro-TESE)	N/A	N/A	Cell apoptosis, cell proliferation, and cell differentiation	-0.1	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of DQ576492 may correlated with the increased risk of Azoospermia.
PIRP00000056	24247010	DQ601609	piR-hsa-31849	Testicular neoplasm	EFO:0004281	downregulation	increased risk	primary testicular tumors	N/A	N/A	N/A	-0.2	The piRNAs dysregulation associated with Testicular neoplasm was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Testicular neoplasm was validated by RT-PCR. The validated results indicated that the downregulation of DQ601609 may correlated with the increased risk of Testicular neoplasm. Moreover, the molecular functions or physiological functions of DQ601609 involving in the pathologies of Testicular neoplasm are illustrated in cell lines in vitro. Altogether, all above results suggested that the downregulation of DQ601609 is possibly correlated with the increased risk of Testicular neoplasm.
PIRP00000057	26265322	piR-006113	piR-hsa-8632	Seminoma	EFO:0003101	downregulation	increased risk	seminoma	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Seminoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Seminoma was validated by RT-PCR. The validated results indicated that the downregulation of piR-006113 may correlated with the increased risk of Seminoma.
PIRP00000057	26265322	piR-006113	piR-hsa-8632	Testicular germ cell tumor	EFO:1000566	downregulation	increased risk	testicular germ cell tumors	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Testicular germ cell tumor was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Testicular germ cell tumor was validated by RT-PCR. The validated results indicated that the downregulation of piR-006113 may correlated with the increased risk of Testicular germ cell tumor.
PIRP00000058	27893851	DQ592932	piR-hsa-23210	Osteoarthritis 	EFO:0002506	upregulation	decreased risk	osteoarthritis patients	N/A	N/A	LPS and TNF¦Á induced inflammatory	-0.2	The piRNAs dysregulation associated with Osteoarthritis  was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Osteoarthritis  was validated by RT-PCR. The validated results indicated that the upregulation of DQ592932 may correlated with the decreased risk of Osteoarthritis . Moreover, the molecular functions or physiological functions of DQ592932 involving in the pathologies of Osteoarthritis  are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of DQ592932 is possibly correlated with the decreased risk of Osteoarthritis .
PIRP00000058	27893851	DQ592932	piR-hsa-23210	Rheumatoid arthritis	EFO:0000685	upregulation	decreased risk	rheumatoid arthritis patients	N/A	N/A	LPS and TNF¦Á induced inflammatory	-0.2	The piRNAs dysregulation associated with Rheumatoid arthritis was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Rheumatoid arthritis was validated by RT-PCR. The validated results indicated that the upregulation of DQ592932 may correlated with the decreased risk of Rheumatoid arthritis. Moreover, the molecular functions or physiological functions of DQ592932 involving in the pathologies of Rheumatoid arthritis are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of DQ592932 is possibly correlated with the decreased risk of Rheumatoid arthritis.
PIRP00000059	28654860	piR-hsa-11231	piR-hsa-11231	Alzheimer's disease	EFO:0000249	downregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-hsa-11231 may correlated with the increased risk of Alzheimer's disease.
PIRP00000060	27323410	piR-34440	piR-hsa-26590	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-34440 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000061	28654860	piR-hsa-20749	piR-hsa-20749	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-20749 may correlated with the increased risk of Alzheimer's disease.
PIRP00000062	25305452	DQ576078	piR-hsa-6341	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ576078 may correlated with the increased risk of Bladder carcinoma.
PIRP00000063	25305452	DQ581488	piR-hsa-11773	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ581488 may correlated with the increased risk of Bladder carcinoma.
PIRP00000064	25305452	DQ577459	piR-hsa-7734	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ577459 may correlated with the increased risk of Bladder carcinoma.
PIRP00000065	21616063	piR-651	piR-hsa-1077	Colon carcinoma	EFO:1001950	upregulation	increased risk	colon cancer tissues	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Colon carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Colon carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-651 may correlated with the increased risk of Colon carcinoma.
PIRP00000066	27429044	hsa_piR_017295	piR-hsa-24143	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_017295 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000067	25998508	piR-54542	piR-hsa-17720	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-54542 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000068	29460056	DQ576170	piR-hsa-6433	Azoospermia	EFO:0000279	downregulation	increased risk	patients with nonobstructive azoospermia (NOA) between successful and unsuccessful sperm retrieval before micro-dissection testicular sperm extraction (micro-TESE)	N/A	N/A	Cell apoptosis, cell proliferation, and cell differentiation	-0.1	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of DQ576170 may correlated with the increased risk of Azoospermia.
PIRP00000069	28654860	piR-hsa-14962	piR-hsa-14962	Alzheimer's disease	EFO:0000249	downregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-hsa-14962 may correlated with the increased risk of Alzheimer's disease.
PIRP00000070	25305452	DQ589140	piR-hsa-19422	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ589140 may correlated with the increased risk of Bladder carcinoma.
PIRP00000071	25305452	DQ576939	piR-hsa-7260	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ576939 may correlated with the increased risk of Bladder carcinoma.
PIRP00000072	25305452	DQ588949	piR-hsa-19231	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ588949 may correlated with the increased risk of Bladder carcinoma.
PIRP00000073	25305452	DQ574109	piR-hsa-4371	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ574109 may correlated with the increased risk of Bladder carcinoma.
PIRP00000074	25305452	DQ579020	piR-hsa-9332	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ579020 may correlated with the increased risk of Bladder carcinoma.
PIRP00000075	28654860	piR-hsa-24169	piR-hsa-24169	Alzheimer's disease	EFO:0000249	downregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-hsa-24169 may correlated with the increased risk of Alzheimer's disease.
PIRP00000076	25305452	DQ596660	piR-hsa-26862	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596660 may correlated with the increased risk of Bladder carcinoma.
PIRP00000077	25305452	DQ581096	piR-hsa-11425	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ581096 may correlated with the increased risk of Bladder carcinoma.
PIRP00000078	27323410	piR-34440	piR-hsa-26590	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-34440 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000079	25305452	DQ588954	piR-hsa-19236	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ588954 may correlated with the increased risk of Bladder carcinoma.
PIRP00000080	27323410	piR-34456	piR-hsa-26606	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-34456 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000081	27323410	piR-36716	piR-hsa-28850	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36716 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000081	27429044	hsa_piR_020814	piR-hsa-28850	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_020814 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000082	25305452	DQ581827	piR-hsa-12081	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ581827 may correlated with the increased risk of Bladder carcinoma.
PIRP00000083	25305452	DQ586065	piR-hsa-16315	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ586065 may correlated with the increased risk of Bladder carcinoma.
PIRP00000084	27323410	piR-33534	piR-hsa-23670	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-33534 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000085	25305452	DQ576153	piR-hsa-6416	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ576153 may correlated with the increased risk of Bladder carcinoma.
PIRP00000086	27323410	piR-43992	piR-hsa-6143	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-43992 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000087	25305452	DQ593739	piR-hsa-23987	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ593739 may correlated with the increased risk of Bladder carcinoma.
PIRP00000088	28654860	piR-hsa-7193	piR-hsa-7193	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-7193 may correlated with the increased risk of Alzheimer's disease.
PIRP00000089	25998508	piR-45808	piR-hsa-7955	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-45808 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000090	27323410	piR-43995	piR-hsa-6146	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-43995 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000091	25305452	DQ597470	piR-hsa-27716	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ597470 may correlated with the increased risk of Bladder carcinoma.
PIRP00000092	25305452	DQ596300	piR-hsa-26516	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596300 may correlated with the increased risk of Bladder carcinoma.
PIRP00000093	25305452	DQ570215	piR-hsa-524	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ570215 may correlated with the increased risk of Bladder carcinoma.
PIRP00000094	25998508	piR-45809	piR-hsa-7956	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-45809 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000095	25998508	piR-57849	piR-hsa-21033	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-57849 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000096	28654860	piR-hsa-6113	piR-hsa-6113	Alzheimer's disease	EFO:0000249	downregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-hsa-6113 may correlated with the increased risk of Alzheimer's disease.
PIRP00000097	27323410	piR-43996	piR-hsa-6147	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-43996 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000097	27429044	hsa_piR_004309	piR-hsa-6147	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_004309 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000098	25779424	FR290353	FR290353	Gastric carcinoma	EFO:0000178	upregulation	poor progonosis	gastric cancer recurrence	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Gastric carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of FR290353 may correlated with the poor progonosis of Gastric carcinoma.
PIRP00000099	25305452	DQ570215	piR-hsa-524	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ570215 may correlated with the increased risk of Bladder carcinoma.
PIRP00000100	25305452	DQ593431	piR-hsa-23679	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ593431 may correlated with the increased risk of Bladder carcinoma.
PIRP00000101	23229900	piR-17458	piR-hsa-24360	Breast carcinoma	EFO:0000305	downregulation	increased risk	resected breast cancer cases	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-17458 may correlated with the increased risk of Breast carcinoma.
PIRP00000102	27323410	piR-36082	piR-hsa-28231	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36082 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000103	25305452	DQ598373	piR-hsa-28588	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ598373 may correlated with the increased risk of Bladder carcinoma.
PIRP00000104	25305452	DQ601697	piR-hsa-31921	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ601697 may correlated with the increased risk of Bladder carcinoma.
PIRP00000105	27429044	hsa_piR_001042	piR-hsa-1338	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_001042 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000106	21616063	piR-651	piR-hsa-1077	Gastric carcinoma	EFO:0000178	upregulation	increased risk and poor progonosis	gastric cancer and  gastric cancer cell lines	N/A	N/A	Cell proliferation	0.40	The piRNAs dysregulation associated with Gastric carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Gastric carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-651 may correlated with the increased risk and poor progonosis of Gastric carcinoma. Moreover, both molecular functions and physiological functions of piR-651 involving in the pathologies of Gastric carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-651 is possibly correlated with the increased risk and poor progonosis of Gastric carcinoma.
PIRP00000107	28654860	piR-hsa-29476	piR-hsa-29476	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-29476 may correlated with the increased risk of Alzheimer's disease.
PIRP00000108	25305452	DQ598294	piR-hsa-28509	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ598294 may correlated with the increased risk of Bladder carcinoma.
PIRP00000109	25305452	DQ601450	piR-hsa-31691	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ601450 may correlated with the increased risk of Bladder carcinoma.
PIRP00000110	27323410	piR-33856	piR-hsa-23992	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-33856 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000111	27429044	hsa_piR_018165	piR-hsa-25313	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_018165 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000112	27323410	piR-35466	piR-hsa-27137	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-35466 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00000113	26205624	piR_011186	piR-hsa-15404	Leukemia	EFO:0000565	upregulation	increased risk	leukemia cell line U937	N/A	CDKN2B; DNMT1; Suv39H1;  EZH2	Cell cycle  and cell apoptosis	0.40	The piRNAs dysregulation associated with Leukemia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Leukemia was validated by RT-PCR. The validated results indicated that the upregulation of piR_011186 may correlated with the increased risk of Leukemia. Moreover, both molecular functions and physiological functions of piR_011186 involving in the pathologies of Leukemia are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR_011186 is possibly correlated with the increased risk of Leukemia.
PIRP00000114	28654860	piR-hsa-29478	piR-hsa-29478	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-29478 may correlated with the increased risk of Alzheimer's disease.
PIRP00000115	29382334	piR-1245	piR-hsa-1963	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer patients	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-1245 may correlated with the increased risk of Bladder carcinoma.
PIRP00000115	29382334	piR-1245	piR-hsa-1963	Breast carcinoma	EFO:0000305	upregulation	increased risk	breast cancer patients	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-1245 may correlated with the increased risk of Breast carcinoma.
PIRP00000115	29382334	piR-1245	piR-hsa-1963	Colorectal cancer	EFO:0005842	upregulation	increased risk and poor progonosis	colorectal cancer patients	N/A	ATF3; BTG1; DUSP1; FAS,NFKBIA; UPP1; SESN2; TP53INP1; MDX1	Cell proliferation, cell death and apoptosis	0.40	The piRNAs dysregulation associated with Colorectal cancer was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Colorectal cancer was validated by RT-PCR. The validated results indicated that the upregulation of piR-1245 may correlated with the increased risk and poor progonosis of Colorectal cancer. Moreover, both molecular functions and physiological functions of piR-1245 involving in the pathologies of Colorectal cancer are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-1245 is possibly correlated with the increased risk and poor progonosis of Colorectal cancer.
PIRP00000115	29382334	piR-1245	piR-hsa-1963	Lung carcinoma	EFO:0001071	upregulation	increased risk	lung cancer patients and cell lines	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Lung carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-1245 may correlated with the increased risk of Lung carcinoma.
PIRP00000115	29382334	piR-1245	piR-hsa-1963	Pancreatic carcinoma	EFO:0002618	upregulation	increased risk	prostate cancer patients	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Pancreatic carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-1245 may correlated with the increased risk of Pancreatic carcinoma.
PIRP00000115	29382334	piR-1245	piR-hsa-1963	Renal carcinoma	EFO:0002890	upregulation	increased risk	kidney cancer patients	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Renal carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-1245 may correlated with the increased risk of Renal carcinoma.
PIRP00000116	26265322	piR-004172	piR-hsa-5963	Seminoma	EFO:0003101	downregulation	increased risk	seminoma	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Seminoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Seminoma was validated by RT-PCR. The validated results indicated that the downregulation of piR-004172 may correlated with the increased risk of Seminoma.
PIRP00000116	26265322	piR-004172	piR-hsa-5963	Testicular germ cell tumor	EFO:1000566	downregulation	increased risk	testicular germ cell tumors	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Testicular germ cell tumor was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Testicular germ cell tumor was validated by RT-PCR. The validated results indicated that the downregulation of piR-004172 may correlated with the increased risk of Testicular germ cell tumor.
PIRP00000117	27323410	piR-35467	piR-hsa-27138	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-35467 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00000118	25305452	DQ596854	piR-hsa-27056	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ596854 may correlated with the increased risk of Bladder carcinoma.
PIRP00000119	29516567	piR-57816	piR-hsa-21000	Neuroblastoma	EFO:0000621	upregulation	increased risk	neuroblastoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Neuroblastoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-57816 may correlated with the increased risk of Neuroblastoma.
PIRP00000120	27323410	piR-35468	piR-hsa-27139	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-35468 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00000121	27429044	hsa_piR_021190	piR-hsa-29417	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_021190 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000122	29460056	DQ576926	piR-hsa-7247	Azoospermia	EFO:0000279	downregulation	increased risk	patients with nonobstructive azoospermia (NOA) between successful and unsuccessful sperm retrieval before micro-dissection testicular sperm extraction (micro-TESE)	N/A	N/A	Cell apoptosis, cell proliferation, and cell differentiation	-0.1	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of DQ576926 may correlated with the increased risk of Azoospermia.
PIRP00000123	27429044	hsa_piR_003728	piR-hsa-5370	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_003728 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000124	28654860	piR-hsa-20752	piR-hsa-20752	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-20752 may correlated with the increased risk of Alzheimer's disease.
PIRP00000125	25305452	DQ575689	piR-hsa-5967	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ575689 may correlated with the increased risk of Bladder carcinoma.
PIRP00000126	27323410	piR-60238	piR-hsa-24360	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-60238 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000127	25305452	DQ578335	piR-hsa-8576	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ578335 may correlated with the increased risk of Bladder carcinoma.
PIRP00000128	25305452	DQ571328	piR-hsa-1331	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ571328 may correlated with the increased risk of Bladder carcinoma.
PIRP00000129	25305452	DQ585901	piR-hsa-16151	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ585901 may correlated with the increased risk of Bladder carcinoma.
PIRP00000130	25305452	DQ579020	piR-hsa-9332	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ579020 may correlated with the increased risk of Bladder carcinoma.
PIRP00000131	25305452	DQ588949	piR-hsa-19231	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ588949 may correlated with the increased risk of Bladder carcinoma.
PIRP00000132	28654860	piR-hsa-9851	piR-hsa-9851	Alzheimer's disease	EFO:0000249	downregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-hsa-9851 may correlated with the increased risk of Alzheimer's disease.
PIRP00000133	27323410	piR-31531	piR-hsa-1742	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-31531 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000134	25305452	DQ571021	piR-hsa-1272	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ571021 may correlated with the increased risk of Bladder carcinoma.
PIRP00000135	25998508	piR-43147	piR-hsa-5341	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-43147 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000136	25305452	DQ575036	piR-hsa-5342	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ575036 may correlated with the increased risk of Bladder carcinoma.
PIRP00000137	25305452	DQ574995	piR-hsa-5301	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ574995 may correlated with the increased risk of Bladder carcinoma.
PIRP00000138	25305452	DQ576844	piR-hsa-7180	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ576844 may correlated with the increased risk of Bladder carcinoma.
PIRP00000139	25305452	DQ574685	piR-hsa-5020	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ574685 may correlated with the increased risk of Bladder carcinoma.
PIRP00000140	28654860	piR-hsa-1580	piR-hsa-1580	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-1580 may correlated with the increased risk of Alzheimer's disease.
PIRP00000141	25305452	DQ600938	piR-hsa-31224	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ600938 may correlated with the increased risk of Bladder carcinoma.
PIRP00000142	28654860	piR-hsa-20485	piR-hsa-20485	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-20485 may correlated with the increased risk of Alzheimer's disease.
PIRP00000143	28654860	piR-hsa-8422	piR-hsa-8422	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-8422 may correlated with the increased risk of Alzheimer's disease.
PIRP00000144	23112866	DQ601609	piR-hsa-31849	Sertoli cell-only syndrome	EFO:1001422	downregulation	increased risk	sertoli cell-only syndrome and spermatogenic failure patients	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Sertoli cell-only syndrome was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Sertoli cell-only syndrome was validated by RT-PCR. The validated results indicated that the downregulation of DQ601609 may correlated with the increased risk of Sertoli cell-only syndrome.
PIRP00000145	25305452	DQ588954	piR-hsa-19236	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ588954 may correlated with the increased risk of Bladder carcinoma.
PIRP00000146	27429044	hsa_piR_001042	piR-hsa-1338	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_001042 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000147	25305452	DQ581827	piR-hsa-12081	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ581827 may correlated with the increased risk of Bladder carcinoma.
PIRP00000148	27323410	piR-33043	piR-hsa-23209	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-33043 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000148	28109471	piR-33043	piR-hsa-23209	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-33043 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00000149	25305452	DQ600790	piR-hsa-31076	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ600790 may correlated with the increased risk of Bladder carcinoma.
PIRP00000150	25305452	DQ586065	piR-hsa-16315	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ586065 may correlated with the increased risk of Bladder carcinoma.
PIRP00000151	25305452	DQ571055	piR-hsa-1306	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ571055 may correlated with the increased risk of Bladder carcinoma.
PIRP00000152	28654860	piR-hsa-13893	piR-hsa-13893	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-13893 may correlated with the increased risk of Alzheimer's disease.
PIRP00000153	28654860	piR-hsa-7193	piR-hsa-7193	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-7193 may correlated with the increased risk of Alzheimer's disease.
PIRP00000154	27197292	piR-11714	piR-hsa-16119	Glioma	EFO:0005543	rs142742690	decreased risk	glioma cell	N/A	N/A	N/A	0.20	The piRNAs dysregulation associated with Glioma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Glioma was validated by RT-PCR. The validated results indicated that the rs142742690 of piR-11714 may correlated with the decreased risk of Glioma. Moreover, the molecular functions or physiological functions of piR-11714 involving in the pathologies of Glioma are illustrated in cell lines in vitro. Altogether, all above results suggested that the rs142742690 of piR-11714 is possibly correlated with the decreased risk of Glioma.
PIRP00000155	27429044	hsa_piR_013306	piR-hsa-18287	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_013306 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000156	25305452	DQ579883	piR-hsa-10123	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ579883 may correlated with the increased risk of Bladder carcinoma.
PIRP00000157	23229900	piR-17458	piR-hsa-24360	Breast carcinoma	EFO:0000305	downregulation	increased risk	resected breast cancer cases	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-17458 may correlated with the increased risk of Breast carcinoma.
PIRP00000157	27323410	piR-60238	piR-hsa-24360	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-60238 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000158	27323410	piR-33880	piR-hsa-24016	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-33880 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000159	29516567	piR-38581	piR-hsa-30715	Neuroblastoma	EFO:0000621	upregulation	increased risk	neuroblastoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Neuroblastoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-38581 may correlated with the increased risk of Neuroblastoma.
PIRP00000160	28654860	piR-hsa-17896	piR-hsa-17896	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-17896 may correlated with the increased risk of Alzheimer's disease.
PIRP00000161	21616063	piR-651	piR-hsa-1077	Breast carcinoma	EFO:0000305	upregulation	increased risk	breast cancer tissues	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-651 may correlated with the increased risk of Breast carcinoma.
PIRP00000161	21616063	piR-651	piR-hsa-1077	Colon carcinoma	EFO:1001950	upregulation	increased risk	colon cancer tissues	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Colon carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Colon carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-651 may correlated with the increased risk of Colon carcinoma.
PIRP00000161	21616063	piR-651	piR-hsa-1077	Gastric carcinoma	EFO:0000178	upregulation	increased risk and poor progonosis	gastric cancer and  gastric cancer cell lines	N/A	N/A	Cell proliferation	0.40	The piRNAs dysregulation associated with Gastric carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Gastric carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-651 may correlated with the increased risk and poor progonosis of Gastric carcinoma. Moreover, both molecular functions and physiological functions of piR-651 involving in the pathologies of Gastric carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-651 is possibly correlated with the increased risk and poor progonosis of Gastric carcinoma.
PIRP00000161	21616063	piR-651	piR-hsa-1077	Lung carcinoma	EFO:0001071	upregulation	increased risk	lung cancer tissues	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Lung carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-651 may correlated with the increased risk of Lung carcinoma.
PIRP00000161	26071182	piR-30924	piR-hsa-1077	Clear cell renal cell carcinomas	EFO:0000349	upregulation	poor progonosis	clear cell renal cell carcinomas patients	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Clear cell renal cell carcinomas was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Clear cell renal cell carcinomas was validated by RT-PCR. The validated results indicated that the upregulation of piR-30924 may correlated with the poor progonosis of Clear cell renal cell carcinomas.
PIRP00000161	27414029	piR-651	piR-hsa-1077	Breast carcinoma	EFO:0000305	upregulation	decreased risk	breast cancer cell lines	hormone treatment	N/A	Cell proliferation and EMT signaling pathway	-0.2	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-651 may correlated with the decreased risk of Breast carcinoma. Moreover, the molecular functions or physiological functions of piR-651 involving in the pathologies of Breast carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-651 is possibly correlated with the decreased risk of Breast carcinoma.
PIRP00000161	27414029	piR-651	piR-hsa-1077	Pancreatic carcinoma	EFO:0002618	upregulation	decreased risk	prostate cancer cell lines	hormone treatment	N/A	Cell proliferation and EMT signaling pathway	-0.2	The piRNAs dysregulation associated with Pancreatic carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Pancreatic carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-651 may correlated with the decreased risk of Pancreatic carcinoma. Moreover, the molecular functions or physiological functions of piR-651 involving in the pathologies of Pancreatic carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-651 is possibly correlated with the decreased risk of Pancreatic carcinoma.
PIRP00000162	25305452	DQ597470	piR-hsa-27716	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ597470 may correlated with the increased risk of Bladder carcinoma.
PIRP00000163	26265322	piR-007509	piR-hsa-10476	Seminoma	EFO:0003101	downregulation	increased risk	seminoma	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Seminoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Seminoma was validated by RT-PCR. The validated results indicated that the downregulation of piR-007509 may correlated with the increased risk of Seminoma.
PIRP00000163	26265322	piR-007509	piR-hsa-10476	Testicular germ cell tumor	EFO:1000566	downregulation	increased risk	testicular germ cell tumors	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Testicular germ cell tumor was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Testicular germ cell tumor was validated by RT-PCR. The validated results indicated that the downregulation of piR-007509 may correlated with the increased risk of Testicular germ cell tumor.
PIRP00000164	27323410	piR-36338	piR-hsa-28487	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36338 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000165	28651359	DQ581121	piR-hsa-11115	Diminished ovarian reserve	EFO:0004770	upregulation	increased risk	patients with diminished ovarian reserve	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Diminished ovarian reserve was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ581121 may correlated with the increased risk of Diminished ovarian reserve.
PIRP00000166	28654860	piR-hsa-14621	piR-hsa-14621	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-14621 may correlated with the increased risk of Alzheimer's disease.
PIRP00000167	27323410	piR-36340	piR-hsa-28489	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36340 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000168	25313140	DQ597960	piR-hsa-28175	Breast carcinoma	EFO:0000305	upregulation	increased risk	breast cancer	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of DQ597960 may correlated with the increased risk of Breast carcinoma.
PIRP00000168	27289065	piR-36026	piR-hsa-28175	Breast carcinoma	EFO:0000305	upregulation	increased risk and poor progonosis	MCF-7 breast cancer cell line	N/A	SERPINA1; LRAT; Caspase-3	Cell appoptosis	0.80	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-36026 may correlated with the increased risk and poor progonosis of Breast carcinoma. Moreover, both molecular functions, physiological functions and/or mechanisms of piR-36026 involving in the pathologies of Breast carcinoma are illustrated in cell lines in vitro. Furthermore, the animal model experiments in vivo (eg. xenograft, transgenic) also demonstrated and supported the piR-36026 dysregulation associated with the pathologies of Breast carcinoma. Altogether, all above results suggested that the upregulation of piR-36026 is possibly correlated with the increased risk and poor progonosis of Breast carcinoma.
PIRP00000169	29382334	piR-1245	piR-hsa-1963	Breast carcinoma	EFO:0000305	upregulation	increased risk	breast cancer patients	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-1245 may correlated with the increased risk of Breast carcinoma.
PIRP00000170	25305452	DQ601697	piR-hsa-31921	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ601697 may correlated with the increased risk of Bladder carcinoma.
PIRP00000171	26210741	piR-021285	piR-hsa-29509	Breast carcinoma	EFO:0000305	rs1326306	increased risk	breast cancer	N/A	N/A	Cell proliferation and EMT signaling pathway	-0.4	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the rs1326306 of piR-021285 may correlated with the increased risk of Breast carcinoma. Moreover, both molecular functions and physiological functions of piR-021285 involving in the pathologies of Breast carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the rs1326306 of piR-021285 is possibly correlated with the increased risk of Breast carcinoma.
PIRP00000172	25305452	DQ570485	piR-hsa-765	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ570485 may correlated with the increased risk of Bladder carcinoma.
PIRP00000173	28826361	piR-31704	piR-hsa-1362	Idiopathic male infertility	EFO:0004248	upregulation	increased risk	sperm concentration and fertilization rate after ICSI	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Idiopathic male infertility was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Idiopathic male infertility was validated by RT-PCR. The validated results indicated that the upregulation of piR-31704 may correlated with the increased risk of Idiopathic male infertility.
PIRP00000174	25305452	DQ601450	piR-hsa-31691	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ601450 may correlated with the increased risk of Bladder carcinoma.
PIRP00000175	27323410	piR-33880	piR-hsa-24016	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-33880 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000176	25305452	DQ590938	piR-hsa-21217	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ590938 may correlated with the increased risk of Bladder carcinoma.
PIRP00000177	25305452	DQ577614	piR-hsa-6917	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ577614 may correlated with the increased risk of Bladder carcinoma.
PIRP00000178	25305452	DQ570324	piR-hsa-180	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ570324 may correlated with the increased risk of Bladder carcinoma.
PIRP00000179	28651359	DQ593431	piR-hsa-23679	Diminished ovarian reserve	EFO:0004770	downregulation	increased risk	patients with diminished ovarian reserve	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Diminished ovarian reserve was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ593431 may correlated with the increased risk of Diminished ovarian reserve.
PIRP00000180	25305452	DQ598918	piR-hsa-29218	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ598918 may correlated with the increased risk of Bladder carcinoma.
PIRP00000181	25305452	DQ596128	piR-hsa-26359	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596128 may correlated with the increased risk of Bladder carcinoma.
PIRP00000182	27323410	piR-35855	piR-hsa-28019	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-35855 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000183	27323410	piR-43771	piR-hsa-5937	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-43771 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000184	25305452	DQ572051	piR-hsa-2331	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ572051 may correlated with the increased risk of Bladder carcinoma.
PIRP00000185	27323410	piR-43772	piR-hsa-5938	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-43772 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000186	25305452	DQ572459	piR-hsa-2695	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ572459 may correlated with the increased risk of Bladder carcinoma.
PIRP00000187	25998508	piR-54436	piR-hsa-17615	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-54436 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000188	28654860	piR-hsa-27248	piR-hsa-27248	Alzheimer's disease	EFO:0000249	downregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-hsa-27248 may correlated with the increased risk of Alzheimer's disease.
PIRP00000189	25305452	DQ576078	piR-hsa-6341	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ576078 may correlated with the increased risk of Bladder carcinoma.
PIRP00000190	28654860	piR-hsa-1580	piR-hsa-1580	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-1580 may correlated with the increased risk of Alzheimer's disease.
PIRP00000191	28654860	piR-hsa-8422	piR-hsa-8422	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-8422 may correlated with the increased risk of Alzheimer's disease.
PIRP00000192	27429044	hsa_piR_001170	piR-hsa-1849	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_001170 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000193	28654860	piR-hsa-22564	piR-hsa-22564	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-22564 may correlated with the increased risk of Alzheimer's disease.
PIRP00000194	28654860	piR-hsa-21131	piR-hsa-21131	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-21131 may correlated with the increased risk of Alzheimer's disease.
PIRP00000195	25305452	DQ600079	piR-hsa-30293	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ600079 may correlated with the increased risk of Bladder carcinoma.
PIRP00000196	25313140	DQ596670	piR-hsa-26872	Breast carcinoma	EFO:0000305	downregulation	increased risk	breast cancer	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of DQ596670 may correlated with the increased risk of Breast carcinoma.
PIRP00000196	27323410	piR-34736	piR-hsa-26872	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	EMT signaling pathway and cell apoptosis 	0.20	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Head and neck squamous cell carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-34736 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma. Moreover, the molecular functions or physiological functions of piR-34736 involving in the pathologies of Head and neck squamous cell carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-34736 is possibly correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00000196	27429044	hsa_piR_019420	piR-hsa-26872	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_019420 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000197	25305452	DQ571998	piR-hsa-2278	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ571998 may correlated with the increased risk of Bladder carcinoma.
PIRP00000198	25305452	DQ593702	piR-hsa-23950	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ593702 may correlated with the increased risk of Bladder carcinoma.
PIRP00000199	21616063	piR-651	piR-hsa-1077	Breast carcinoma	EFO:0000305	upregulation	increased risk	breast cancer tissues	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-651 may correlated with the increased risk of Breast carcinoma.
PIRP00000199	27414029	piR-651	piR-hsa-1077	Breast carcinoma	EFO:0000305	upregulation	decreased risk	breast cancer cell lines	hormone treatment	N/A	Cell proliferation and EMT signaling pathway	-0.2	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-651 may correlated with the decreased risk of Breast carcinoma. Moreover, the molecular functions or physiological functions of piR-651 involving in the pathologies of Breast carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-651 is possibly correlated with the decreased risk of Breast carcinoma.
PIRP00000200	27068805	piR-31068	piR-hsa-1207	Azoospermia	EFO:0000279	downregulation	increased risk	seminal plasma of infertile patients	N/A	N/A	N/A	-0.2	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of piR-31068 may correlated with the increased risk of Azoospermia. Moreover, the molecular functions or physiological functions of piR-31068 involving in the pathologies of Azoospermia are illustrated in cell lines in vitro. Altogether, all above results suggested that the downregulation of piR-31068 is possibly correlated with the increased risk of Azoospermia.
PIRP00000201	27323410	piR-33856	piR-hsa-23992	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-33856 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000202	25305452	DQ600790	piR-hsa-31076	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ600790 may correlated with the increased risk of Bladder carcinoma.
PIRP00000203	25998508	piR-36318	piR-hsa-28467	Renal cell carcinoma	EFO:0000681	upregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36318 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000204	25305452	DQ593358	piR-hsa-23621	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ593358 may correlated with the increased risk of Bladder carcinoma.
PIRP00000204	27429044	hsa_piR_016946	piR-hsa-23621	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_016946 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000205	27829231	DQ596306	piR-hsa-26522	Lung adenocarcinoma	EFO:0000571	upregulation	poor progonosis	lung adenocarcinoma samples	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Lung adenocarcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung adenocarcinoma was validated by RT-PCR. The validated results indicated that the upregulation of DQ596306 may correlated with the poor progonosis of Lung adenocarcinoma.
PIRP00000206	27429044	hsa_piR_019822	piR-hsa-27490	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_019822 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000207	27429044	hsa_piR_019914	piR-hsa-27622	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_019914 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000208	27429044	hsa_piR_016975	piR-hsa-23663	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_016975 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000209	26408181	piR-55490	piR-hsa-9	Lung carcinoma	EFO:0001071	downregulation	increased risk	lung cancer cells	N/A	mTOR	Akt/mTOR signaling pathway	-0.8	The piRNAs dysregulation associated with Lung carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of piR-55490 may correlated with the increased risk of Lung carcinoma. Moreover, both molecular functions, physiological functions and/or mechanisms of piR-55490 involving in the pathologies of Lung carcinoma are illustrated in cell lines in vitro. Furthermore, the animal model experiments in vivo (eg. xenograft, transgenic) also demonstrated and supported the piR-55490 dysregulation associated with the pathologies of Lung carcinoma. Altogether, all above results suggested that the downregulation of piR-55490 is possibly correlated with the increased risk of Lung carcinoma.
PIRP00000210	25305452	DQ596307	piR-hsa-26523	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596307 may correlated with the increased risk of Bladder carcinoma.
PIRP00000211	25305452	DQ597100	piR-hsa-27390	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ597100 may correlated with the increased risk of Bladder carcinoma.
PIRP00000212	25305452	DQ596308	piR-hsa-26524	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596308 may correlated with the increased risk of Bladder carcinoma.
PIRP00000213	27429044	hsa_piR_019824	piR-hsa-27492	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_019824 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000214	28109471	NONHSAT067200	NONHSAT067200	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	tobacco	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of NONHSAT067200 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00000215	25305452	DQ597101	piR-hsa-27391	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ597101 may correlated with the increased risk of Bladder carcinoma.
PIRP00000216	25305452	DQ596309	piR-hsa-26525	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596309 may correlated with the increased risk of Bladder carcinoma.
PIRP00000216	27829231	DQ596309	piR-hsa-26525	Lung adenocarcinoma	EFO:0000571	upregulation	poor progonosis	lung adenocarcinoma samples	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Lung adenocarcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung adenocarcinoma was validated by RT-PCR. The validated results indicated that the upregulation of DQ596309 may correlated with the poor progonosis of Lung adenocarcinoma.
PIRP00000217	28651359	DQ594453	piR-hsa-24672	Diminished ovarian reserve	EFO:0004770	upregulation	increased risk	patients with diminished ovarian reserve	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Diminished ovarian reserve was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ594453 may correlated with the increased risk of Diminished ovarian reserve.
PIRP00000218	28423657	piR-35127	piR-hsa-27351	Breast carcinoma	EFO:0000305	downregulation	increased risk	breast cancer cell lines	N/A	N/A	AMPK signaling pathway	-0.05	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-35127 may correlated with the increased risk of Breast carcinoma.
PIRP00000218	28423657	piR-35127	piR-hsa-27351	Lung carcinoma	EFO:0001071	downregulation	increased risk	lung cancer patients and lung cancer cell lines	N/A	AMPK	AMPK signaling pathway	-0.4	The piRNAs dysregulation associated with Lung carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of piR-35127 may correlated with the increased risk of Lung carcinoma. Moreover, both molecular functions and physiological functions of piR-35127 involving in the pathologies of Lung carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the downregulation of piR-35127 is possibly correlated with the increased risk of Lung carcinoma.
PIRP00000219	25305452	DQ596310	piR-hsa-26526	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596310 may correlated with the increased risk of Bladder carcinoma.
PIRP00000220	28826361	piR-39888	piR-hsa-32046	Low 2PN rates among the ICSI operators	UBERON:0000922	upregulation	decreased risk	sperm concentration and fertilization rate after ICSI	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Low 2PN rates among the ICSI operators was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Low 2PN rates among the ICSI operators was validated by RT-PCR. The validated results indicated that the upregulation of piR-39888 may correlated with the decreased risk of Low 2PN rates among the ICSI operators.
PIRP00000221	28826361	piR-39888	piR-hsa-32046	Idiopathic male infertility	EFO:0004248	upregulation	increased risk	sperm concentration and fertilization rate after ICSI	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Idiopathic male infertility was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Idiopathic male infertility was validated by RT-PCR. The validated results indicated that the upregulation of piR-39888 may correlated with the increased risk of Idiopathic male infertility.
PIRP00000222	25305452	DQ596311	piR-hsa-26527	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596311 may correlated with the increased risk of Bladder carcinoma.
PIRP00000222	25313140	DQ596311	piR-hsa-26527	Breast carcinoma	EFO:0000305	downregulation	increased risk	breast cancer	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of DQ596311 may correlated with the increased risk of Breast carcinoma.
PIRP00000222	27429044	hsa_piR_019168	piR-hsa-26527	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_019168 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000223	26148798	DQ597347	piR-hsa-27622	Asthma	EFO:0000270	upregulation	increased risk	asthmatic patientss	N/A	N/A	Akt signaling pathway	0.10	The piRNAs dysregulation associated with Asthma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Asthma was validated by RT-PCR. The validated results indicated that the upregulation of DQ597347 may correlated with the increased risk of Asthma.
PIRP00000224	27323410	piR-41794	piR-hsa-3961	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-41794 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000225	27429044	hsa_piR_019951	piR-hsa-27140	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_019951 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000226	25305452	DQ596313	piR-hsa-26529	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596313 may correlated with the increased risk of Bladder carcinoma.
PIRP00000227	25305452	DQ592048	piR-hsa-22296	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ592048 may correlated with the increased risk of Bladder carcinoma.
PIRP00000228	25998508	piR-45808	piR-hsa-7955	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-45808 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000229	25998508	piR-45809	piR-hsa-7956	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-45809 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000230	28651359	DQ598107	piR-hsa-28322	Diminished ovarian reserve	EFO:0004770	upregulation	increased risk	patients with diminished ovarian reserve	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Diminished ovarian reserve was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ598107 may correlated with the increased risk of Diminished ovarian reserve.
PIRP00000231	27323410	piR-33510	piR-hsa-22905	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-33510 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000232	25305452	DQ577740	piR-hsa-7999	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ577740 may correlated with the increased risk of Bladder carcinoma.
PIRP00000233	27429044	hsa_piR_010155	piR-hsa-13940	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_010155 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000234	28654860	piR-hsa-28243	piR-hsa-28243	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-28243 may correlated with the increased risk of Alzheimer's disease.
PIRP00000235	25779424	FR064000	FR064000	Gastric carcinoma	EFO:0000178	upregulation	poor progonosis	gastric cancer recurrence	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Gastric carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of FR064000 may correlated with the poor progonosis of Gastric carcinoma.
PIRP00000236	25779424	FR064000	FR064000	Gastric carcinoma	EFO:0000178	upregulation	poor progonosis	gastric cancer recurrence	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Gastric carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of FR064000 may correlated with the poor progonosis of Gastric carcinoma.
PIRP00000237	28654860	piR-hsa-21636	piR-hsa-21636	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-21636 may correlated with the increased risk of Alzheimer's disease.
PIRP00000238	25305452	DQ590938	piR-hsa-21217	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ590938 may correlated with the increased risk of Bladder carcinoma.
PIRP00000239	25305452	DQ577543	piR-hsa-7817	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ577543 may correlated with the increased risk of Bladder carcinoma.
PIRP00000240	27893851	DQ592932	piR-hsa-23210	Osteoarthritis 	EFO:0002506	upregulation	decreased risk	osteoarthritis patients	N/A	N/A	LPS and TNF¦Á induced inflammatory	-0.2	The piRNAs dysregulation associated with Osteoarthritis  was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Osteoarthritis  was validated by RT-PCR. The validated results indicated that the upregulation of DQ592932 may correlated with the decreased risk of Osteoarthritis . Moreover, the molecular functions or physiological functions of DQ592932 involving in the pathologies of Osteoarthritis  are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of DQ592932 is possibly correlated with the decreased risk of Osteoarthritis .
PIRP00000241	27323410	piR-30229	piR-hsa-426	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-30229 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000241	28109471	piR-30229	piR-hsa-426	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-30229 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00000242	27429044	hsa_piR_014620	piR-hsa-20266	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_014620 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000243	25998508	piR-39894	piR-hsa-32052	Renal cell carcinoma	EFO:0000681	upregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	0.20	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Renal cell carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-39894 may correlated with the increased risk and poor progonosis of Renal cell carcinoma. Moreover, the molecular functions or physiological functions of piR-39894 involving in the pathologies of Renal cell carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-39894 is possibly correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000244	28423657	piR-34871	piR-hsa-27007	Breast carcinoma	EFO:0000305	upregulation	increased risk	breast cancer cell lines	N/A	N/A	AMPK signaling pathway	0.05	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-34871 may correlated with the increased risk of Breast carcinoma.
PIRP00000244	28423657	piR-34871	piR-hsa-27007	Lung carcinoma	EFO:0001071	upregulation	increased risk	lung cancer patients and lung cancer cell lines	N/A	AMPK	AMPK signaling pathway	0.40	The piRNAs dysregulation associated with Lung carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-34871 may correlated with the increased risk of Lung carcinoma. Moreover, both molecular functions and physiological functions of piR-34871 involving in the pathologies of Lung carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-34871 is possibly correlated with the increased risk of Lung carcinoma.
PIRP00000245	25998508	piR-32635	piR-hsa-12746	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-32635 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000246	25305452	DQ588949	piR-hsa-19231	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ588949 may correlated with the increased risk of Bladder carcinoma.
PIRP00000247	25998508	piR-32636	piR-hsa-12747	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-32636 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000248	25998508	piR-32637	piR-hsa-12748	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-32637 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000249	25305452	DQ580466	piR-hsa-10692	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ580466 may correlated with the increased risk of Bladder carcinoma.
PIRP00000250	29516567	piR-57816	piR-hsa-21000	Neuroblastoma	EFO:0000621	upregulation	increased risk	neuroblastoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Neuroblastoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-57816 may correlated with the increased risk of Neuroblastoma.
PIRP00000251	25779424	FR157678	FR157678	Gastric carcinoma	EFO:0000178	upregulation	poor progonosis	gastric cancer recurrence	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Gastric carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of FR157678 may correlated with the poor progonosis of Gastric carcinoma.
PIRP00000252	25305452	DQ588954	piR-hsa-19236	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ588954 may correlated with the increased risk of Bladder carcinoma.
PIRP00000253	28654860	piR-hsa-23566	piR-hsa-23566	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-23566 may correlated with the increased risk of Alzheimer's disease.
PIRP00000254	25305452	DQ576917	piR-hsa-7238	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ576917 may correlated with the increased risk of Bladder carcinoma.
PIRP00000255	27323410	piR-30840	piR-hsa-993	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-30840 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000256	25305452	DQ599457	piR-hsa-29714	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ599457 may correlated with the increased risk of Bladder carcinoma.
PIRP00000257	25305452	DQ599458	piR-hsa-29715	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ599458 may correlated with the increased risk of Bladder carcinoma.
PIRP00000258	25305452	DQ599459	piR-hsa-29716	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ599459 may correlated with the increased risk of Bladder carcinoma.
PIRP00000259	29460056	DQ579754	piR-hsa-10009	Azoospermia	EFO:0000279	downregulation	increased risk	patients with nonobstructive azoospermia (NOA) between successful and unsuccessful sperm retrieval before micro-dissection testicular sperm extraction (micro-TESE)	N/A	N/A	Cell apoptosis, cell proliferation, and cell differentiation	-0.1	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of DQ579754 may correlated with the increased risk of Azoospermia.
PIRP00000260	27323410	piR-36241	piR-hsa-28390	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36241 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000261	25305452	DQ597470	piR-hsa-27716	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ597470 may correlated with the increased risk of Bladder carcinoma.
PIRP00000262	27429044	hsa_piR_017724	piR-hsa-24684	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_017724 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000263	27323410	piR-33044	piR-hsa-23210	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-33044 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000264	25305452	DQ596307	piR-hsa-26523	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596307 may correlated with the increased risk of Bladder carcinoma.
PIRP00000265	28654860	piR-hsa-23259	piR-hsa-23259	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-23259 may correlated with the increased risk of Alzheimer's disease.
PIRP00000266	26408181	piR-55490	piR-hsa-9	Lung carcinoma	EFO:0001071	downregulation	increased risk	lung cancer cells	N/A	mTOR	Akt/mTOR signaling pathway	-0.8	The piRNAs dysregulation associated with Lung carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of piR-55490 may correlated with the increased risk of Lung carcinoma. Moreover, both molecular functions, physiological functions and/or mechanisms of piR-55490 involving in the pathologies of Lung carcinoma are illustrated in cell lines in vitro. Furthermore, the animal model experiments in vivo (eg. xenograft, transgenic) also demonstrated and supported the piR-55490 dysregulation associated with the pathologies of Lung carcinoma. Altogether, all above results suggested that the downregulation of piR-55490 is possibly correlated with the increased risk of Lung carcinoma.
PIRP00000267	25305452	DQ596308	piR-hsa-26524	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596308 may correlated with the increased risk of Bladder carcinoma.
PIRP00000268	28654860	piR-hsa-4000	piR-hsa-4000	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-4000 may correlated with the increased risk of Alzheimer's disease.
PIRP00000269	25305452	DQ597293	piR-hsa-27568	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ597293 may correlated with the increased risk of Bladder carcinoma.
PIRP00000270	25305452	DQ593305	piR-hsa-23568	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ593305 may correlated with the increased risk of Bladder carcinoma.
PIRP00000271	25305452	DQ599177	piR-hsa-29448	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ599177 may correlated with the increased risk of Bladder carcinoma.
PIRP00000272	25305452	DQ596309	piR-hsa-26525	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596309 may correlated with the increased risk of Bladder carcinoma.
PIRP00000273	27323410	piR-36245	piR-hsa-28394	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36245 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000273	28109471	piR-36245	piR-hsa-28394	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36245 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00000274	25305452	DQ596310	piR-hsa-26526	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596310 may correlated with the increased risk of Bladder carcinoma.
PIRP00000275	27323410	piR-36246	piR-hsa-28395	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36246 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000275	27429044	hsa_piR_020498	piR-hsa-28395	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_020498 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000276	25998508	piR-58594	piR-hsa-21746	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-58594 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000277	25305452	DQ596311	piR-hsa-26527	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596311 may correlated with the increased risk of Bladder carcinoma.
PIRP00000278	27323410	piR-33534	piR-hsa-23670	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-33534 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000279	27429044	hsa_piR_020657	piR-hsa-28629	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_020657 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000280	25998508	piR-58595	piR-hsa-21747	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-58595 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000281	25305452	DQ595212	piR-hsa-25473	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ595212 may correlated with the increased risk of Bladder carcinoma.
PIRP00000282	25305452	DQ601697	piR-hsa-31921	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ601697 may correlated with the increased risk of Bladder carcinoma.
PIRP00000283	27429044	hsa_piR_020362	piR-hsa-28183	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_020362 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000284	28654860	piR-hsa-14119	piR-hsa-14119	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-14119 may correlated with the increased risk of Alzheimer's disease.
PIRP00000285	29460056	DQ573385	piR-hsa-3678	Azoospermia	EFO:0000279	downregulation	increased risk	patients with nonobstructive azoospermia (NOA) between successful and unsuccessful sperm retrieval before micro-dissection testicular sperm extraction (micro-TESE)	N/A	N/A	Cell apoptosis, cell proliferation, and cell differentiation	-0.1	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of DQ573385 may correlated with the increased risk of Azoospermia.
PIRP00000286	25305452	DQ592938	piR-hsa-23216	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ592938 may correlated with the increased risk of Bladder carcinoma.
PIRP00000286	27429044	hsa_piR_016664	piR-hsa-23216	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_016664 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000287	25305452	DQ596313	piR-hsa-26529	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596313 may correlated with the increased risk of Bladder carcinoma.
PIRP00000288	25305452	DQ592048	piR-hsa-22296	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ592048 may correlated with the increased risk of Bladder carcinoma.
PIRP00000289	25313140	DQ598183	piR-hsa-28398	Breast carcinoma	EFO:0000305	downregulation	increased risk	breast cancer	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of DQ598183 may correlated with the increased risk of Breast carcinoma.
PIRP00000289	27429044	hsa_piR_020499	piR-hsa-28398	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_020499 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000290	27429044	hsa_piR_020363	piR-hsa-28185	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_020363 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000291	25305452	DQ601450	piR-hsa-31691	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ601450 may correlated with the increased risk of Bladder carcinoma.
PIRP00000292	27429044	hsa_piR_020364	piR-hsa-28186	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_020364 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000293	27323410	piR-35466	piR-hsa-27137	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-35466 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00000294	27429044	hsa_piR_020450	piR-hsa-28319	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_020450 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000295	27323410	piR-35467	piR-hsa-27138	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-35467 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00000296	27323410	piR-35468	piR-hsa-27139	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-35468 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00000297	25998508	piR-43607	piR-hsa-5773	Renal cell carcinoma	EFO:0000681	upregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	0.20	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Renal cell carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-43607 may correlated with the increased risk and poor progonosis of Renal cell carcinoma. Moreover, the molecular functions or physiological functions of piR-43607 involving in the pathologies of Renal cell carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-43607 is possibly correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000298	25305452	DQ597858	piR-hsa-28088	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ597858 may correlated with the increased risk of Bladder carcinoma.
PIRP00000299	28654860	piR-hsa-27400	piR-hsa-27400	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-27400 may correlated with the increased risk of Alzheimer's disease.
PIRP00000300	24732595	piR-823	piR-hsa-1282	Multiple myeloma	EFO:0001378	upregulation	increased risk and poor progonosis	multiple myeloma patients and multiple myeloma cell lines	N/A	DNMT3A and 3B	Cell proliferation, cell apoptosis, cell cycle and angiogenesis	0.80	The piRNAs dysregulation associated with Multiple myeloma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Multiple myeloma was validated by RT-PCR. The validated results indicated that the upregulation of piR-823 may correlated with the increased risk and poor progonosis of Multiple myeloma. Moreover, both molecular functions, physiological functions and/or mechanisms of piR-823 involving in the pathologies of Multiple myeloma are illustrated in cell lines in vitro. Furthermore, the animal model experiments in vivo (eg. xenograft, transgenic) also demonstrated and supported the piR-823 dysregulation associated with the pathologies of Multiple myeloma. Altogether, all above results suggested that the upregulation of piR-823 is possibly correlated with the increased risk and poor progonosis of Multiple myeloma.
PIRP00000301	27197292	piR-598	piR-hsa-1006	Glioma	EFO:0005543	rs147061479	increased risk	glioma cell	N/A	N/A	Cell proliferation	-0.4	The piRNAs dysregulation associated with Glioma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Glioma was validated by RT-PCR. The validated results indicated that the rs147061479 of piR-598 may correlated with the increased risk of Glioma. Moreover, both molecular functions and physiological functions of piR-598 involving in the pathologies of Glioma are illustrated in cell lines in vitro. Altogether, all above results suggested that the rs147061479 of piR-598 is possibly correlated with the increased risk of Glioma.
PIRP00000302	25305452	DQ575105	piR-hsa-5411	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ575105 may correlated with the increased risk of Bladder carcinoma.
PIRP00000303	25998508	piR-32105	piR-hsa-12232	Renal cell carcinoma	EFO:0000681	upregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-32105 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000304	30555542	piR-54265	piR-hsa-17444	Colorectal adenocarcinoma	EFO:0000365	upregulation	increased risk	colorectal adenocarcinoma	N/A	PIWIL2	STAT3 signaling pathway, cell proliferation, metastasis and chemoresistance	0.80	The piRNAs dysregulation associated with Colorectal adenocarcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Colorectal adenocarcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-54265 may correlated with the increased risk of Colorectal adenocarcinoma. Moreover, both molecular functions, physiological functions and/or mechanisms of piR-54265 involving in the pathologies of Colorectal adenocarcinoma are illustrated in cell lines in vitro. Furthermore, the animal model experiments in vivo (eg. xenograft, transgenic) also demonstrated and supported the piR-54265 dysregulation associated with the pathologies of Colorectal adenocarcinoma. Altogether, all above results suggested that the upregulation of piR-54265 is possibly correlated with the increased risk of Colorectal adenocarcinoma.
PIRP00000305	27323410	piR-35284	piR-hsa-27493	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-35284 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000306	25305452	DQ585043	piR-hsa-15354	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ585043 may correlated with the increased risk of Bladder carcinoma.
PIRP00000307	25305452	DQ576939	piR-hsa-7260	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ576939 may correlated with the increased risk of Bladder carcinoma.
PIRP00000308	27429044	hsa_piR_003728	piR-hsa-5370	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_003728 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000309	29460056	DQ576926	piR-hsa-7247	Azoospermia	EFO:0000279	downregulation	increased risk	patients with nonobstructive azoospermia (NOA) between successful and unsuccessful sperm retrieval before micro-dissection testicular sperm extraction (micro-TESE)	N/A	N/A	Cell apoptosis, cell proliferation, and cell differentiation	-0.1	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of DQ576926 may correlated with the increased risk of Azoospermia.
PIRP00000310	28654860	piR-hsa-27489	piR-hsa-27489	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-27489 may correlated with the increased risk of Alzheimer's disease.
PIRP00000311	27323410	piR-35469	piR-hsa-27140	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-35469 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000312	28654860	piR-hsa-27133	piR-hsa-27133	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-27133 may correlated with the increased risk of Alzheimer's disease.
PIRP00000313	28654860	piR-hsa-27134	piR-hsa-27134	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-27134 may correlated with the increased risk of Alzheimer's disease.
PIRP00000314	25305452	DQ570901	piR-hsa-1152	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ570901 may correlated with the increased risk of Bladder carcinoma.
PIRP00000315	27429044	hsa_piR_020828	piR-hsa-28875	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_020828 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000316	25779424	FR222326	FR222326	Gastric carcinoma	EFO:0000178	upregulation	poor progonosis	gastric cancer recurrence	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Gastric carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of FR222326 may correlated with the poor progonosis of Gastric carcinoma.
PIRP00000317	25313140	DQ598677	piR-hsa-28877	Breast carcinoma	EFO:0000305	upregulation	increased risk	breast cancer	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of DQ598677 may correlated with the increased risk of Breast carcinoma.
PIRP00000317	27429044	hsa_piR_020829	piR-hsa-28877	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_020829 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000318	25305452	DQ600790	piR-hsa-31076	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ600790 may correlated with the increased risk of Bladder carcinoma.
PIRP00000319	29382334	piR-1245	piR-hsa-1963	Colorectal cancer	EFO:0005842	upregulation	increased risk and poor progonosis	colorectal cancer patients	N/A	ATF3; BTG1; DUSP1; FAS,NFKBIA; UPP1; SESN2; TP53INP1; MDX1	Cell proliferation, cell death and apoptosis	0.40	The piRNAs dysregulation associated with Colorectal cancer was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Colorectal cancer was validated by RT-PCR. The validated results indicated that the upregulation of piR-1245 may correlated with the increased risk and poor progonosis of Colorectal cancer. Moreover, both molecular functions and physiological functions of piR-1245 involving in the pathologies of Colorectal cancer are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-1245 is possibly correlated with the increased risk and poor progonosis of Colorectal cancer.
PIRP00000320	28654860	piR-hsa-27138	piR-hsa-27138	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-27138 may correlated with the increased risk of Alzheimer's disease.
PIRP00000321	28654860	piR-hsa-27139	piR-hsa-27139	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-27139 may correlated with the increased risk of Alzheimer's disease.
PIRP00000322	28654860	piR-hsa-19112	piR-hsa-19112	Alzheimer's disease	EFO:0000249	downregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-hsa-19112 may correlated with the increased risk of Alzheimer's disease.
PIRP00000323	27429044	hsa_piR_020809	piR-hsa-28839	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_020809 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000324	25305452	DQ580006	piR-hsa-10246	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ580006 may correlated with the increased risk of Bladder carcinoma.
PIRP00000324	27429044	hsa_piR_007336	piR-hsa-10246	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_007336 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000325	27429044	hsa_piR_019201	piR-hsa-26570	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_019201 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000326	27323410	piR-57125	piR-hsa-20266	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-57125 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00000327	26095918	piR-L-163	piR-L-163	Non-small cell lung carcinoma	EFO:0003060	downregulation	increased risk and poor progonosis	non-small cell lung cancer (NSCLC) cell lines	N/A	p-ERM	Cell cycle  and cell migration and cell invasion	-0.6	The piRNAs dysregulation associated with Non-small cell lung carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Non-small cell lung carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of piR-L-163 may correlated with the increased risk and poor progonosis of Non-small cell lung carcinoma. Moreover, both molecular functions, physiological functions and mechanisms of piR-L-163 involving in the pathologies of Non-small cell lung carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the downregulation of piR-L-163 is possibly correlated with the increased risk and poor progonosis of Non-small cell lung carcinoma.
PIRP00000328	25305452	DQ591339	piR-hsa-21604	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ591339 may correlated with the increased risk of Bladder carcinoma.
PIRP00000329	23229900	piR-20582	piR-hsa-28527	Breast carcinoma	EFO:0000305	upregulation	increased risk	resected breast cancer cases	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-20582 may correlated with the increased risk of Breast carcinoma.
PIRP00000330	27323410	piR-36338	piR-hsa-28487	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36338 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000331	25305452	DQ590181	piR-hsa-20405	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ590181 may correlated with the increased risk of Bladder carcinoma.
PIRP00000332	25305452	DQ597293	piR-hsa-27568	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ597293 may correlated with the increased risk of Bladder carcinoma.
PIRP00000333	25305452	DQ593305	piR-hsa-23568	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ593305 may correlated with the increased risk of Bladder carcinoma.
PIRP00000334	27323410	piR-36340	piR-hsa-28489	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36340 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000335	26265322	piR-006113	piR-hsa-8632	Seminoma	EFO:0003101	downregulation	increased risk	seminoma	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Seminoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Seminoma was validated by RT-PCR. The validated results indicated that the downregulation of piR-006113 may correlated with the increased risk of Seminoma.
PIRP00000336	25313140	DQ597960	piR-hsa-28175	Breast carcinoma	EFO:0000305	upregulation	increased risk	breast cancer	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of DQ597960 may correlated with the increased risk of Breast carcinoma.
PIRP00000336	27289065	piR-36026	piR-hsa-28175	Breast carcinoma	EFO:0000305	upregulation	increased risk and poor progonosis	MCF-7 breast cancer cell line	N/A	SERPINA1; LRAT; Caspase-3	Cell appoptosis	0.80	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-36026 may correlated with the increased risk and poor progonosis of Breast carcinoma. Moreover, both molecular functions, physiological functions and/or mechanisms of piR-36026 involving in the pathologies of Breast carcinoma are illustrated in cell lines in vitro. Furthermore, the animal model experiments in vivo (eg. xenograft, transgenic) also demonstrated and supported the piR-36026 dysregulation associated with the pathologies of Breast carcinoma. Altogether, all above results suggested that the upregulation of piR-36026 is possibly correlated with the increased risk and poor progonosis of Breast carcinoma.
PIRP00000337	27429044	hsa_piR_004309	piR-hsa-6147	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_004309 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000338	25305452	DQ585585	piR-hsa-15880	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ585585 may correlated with the increased risk of Bladder carcinoma.
PIRP00000339	25305452	DQ592938	piR-hsa-23216	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ592938 may correlated with the increased risk of Bladder carcinoma.
PIRP00000340	25998508	piR-54403	piR-hsa-17582	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-54403 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000341	25305452	DQ591874	piR-hsa-22122	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ591874 may correlated with the increased risk of Bladder carcinoma.
PIRP00000342	29460056	DQ586061	piR-hsa-16311	Azoospermia	EFO:0000279	downregulation	increased risk	patients with nonobstructive azoospermia (NOA) between successful and unsuccessful sperm retrieval before micro-dissection testicular sperm extraction (micro-TESE)	N/A	N/A	Cell apoptosis, cell proliferation, and cell differentiation	-0.1	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of DQ586061 may correlated with the increased risk of Azoospermia.
PIRP00000343	23112866	DQ589977	piR-hsa-20230	Sertoli cell-only syndrome	EFO:1001422	downregulation	increased risk	sertoli cell-only syndrome and spermatogenic failure patients	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Sertoli cell-only syndrome was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Sertoli cell-only syndrome was validated by RT-PCR. The validated results indicated that the downregulation of DQ589977 may correlated with the increased risk of Sertoli cell-only syndrome.
PIRP00000344	27323410	piR-37523	piR-hsa-29714	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-37523 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000345	29382334	piR-1245	piR-hsa-1963	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer patients	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-1245 may correlated with the increased risk of Bladder carcinoma.
PIRP00000345	29382334	piR-1245	piR-hsa-1963	Breast carcinoma	EFO:0000305	upregulation	increased risk	breast cancer patients	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-1245 may correlated with the increased risk of Breast carcinoma.
PIRP00000345	29382334	piR-1245	piR-hsa-1963	Lung carcinoma	EFO:0001071	upregulation	increased risk	lung cancer patients and cell lines	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Lung carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-1245 may correlated with the increased risk of Lung carcinoma.
PIRP00000345	29382334	piR-1245	piR-hsa-1963	Pancreatic carcinoma	EFO:0002618	upregulation	increased risk	prostate cancer patients	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Pancreatic carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-1245 may correlated with the increased risk of Pancreatic carcinoma.
PIRP00000345	29382334	piR-1245	piR-hsa-1963	Renal carcinoma	EFO:0002890	upregulation	increased risk	kidney cancer patients	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Renal carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-1245 may correlated with the increased risk of Renal carcinoma.
PIRP00000346	25305452	DQ585568	piR-hsa-15863	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ585568 may correlated with the increased risk of Bladder carcinoma.
PIRP00000347	27323410	piR-37524	piR-hsa-29715	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-37524 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000348	25305452	DQ585569	piR-hsa-15864	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ585569 may correlated with the increased risk of Bladder carcinoma.
PIRP00000349	27323410	piR-37525	piR-hsa-29716	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-37525 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000350	25998508	piR-4018	piR-hsa-5748	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-4018 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000351	25305452	DQ585261	piR-hsa-15572	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ585261 may correlated with the increased risk of Bladder carcinoma.
PIRP00000352	25305452	DQ584252	piR-hsa-14474	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ584252 may correlated with the increased risk of Bladder carcinoma.
PIRP00000353	25305452	DQ582387	piR-hsa-12610	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ582387 may correlated with the increased risk of Bladder carcinoma.
PIRP00000354	25305452	DQ575689	piR-hsa-5967	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ575689 may correlated with the increased risk of Bladder carcinoma.
PIRP00000355	28654860	piR-hsa-13893	piR-hsa-13893	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-13893 may correlated with the increased risk of Alzheimer's disease.
PIRP00000356	25305452	DQ578335	piR-hsa-8576	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ578335 may correlated with the increased risk of Bladder carcinoma.
PIRP00000357	25305452	DQ576153	piR-hsa-6416	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ576153 may correlated with the increased risk of Bladder carcinoma.
PIRP00000358	27323410	piR-43992	piR-hsa-6143	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-43992 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000359	27323410	piR-61298	piR-hsa-25447	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-61298 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000360	26265322	piR-007509	piR-hsa-10476	Seminoma	EFO:0003101	downregulation	increased risk	seminoma	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Seminoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Seminoma was validated by RT-PCR. The validated results indicated that the downregulation of piR-007509 may correlated with the increased risk of Seminoma.
PIRP00000361	25998508	piR-43147	piR-hsa-5341	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-43147 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000362	25305452	DQ585286	piR-hsa-15597	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ585286 may correlated with the increased risk of Bladder carcinoma.
PIRP00000363	25305452	DQ600174	piR-hsa-30374	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ600174 may correlated with the increased risk of Bladder carcinoma.
PIRP00000364	25305452	DQ585287	piR-hsa-15598	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ585287 may correlated with the increased risk of Bladder carcinoma.
PIRP00000365	25305452	DQ575036	piR-hsa-5342	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ575036 may correlated with the increased risk of Bladder carcinoma.
PIRP00000366	25305452	DQ574995	piR-hsa-5301	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ574995 may correlated with the increased risk of Bladder carcinoma.
PIRP00000367	27323410	piR-43995	piR-hsa-6146	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-43995 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000368	27323410	piR-43996	piR-hsa-6147	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-43996 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000368	27429044	hsa_piR_004309	piR-hsa-6147	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_004309 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000369	25998508	piR-32985	piR-hsa-13196	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-32985 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000370	25305452	DQ599457	piR-hsa-29714	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ599457 may correlated with the increased risk of Bladder carcinoma.
PIRP00000370	27323410	piR-37523	piR-hsa-29714	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-37523 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000371	25305452	DQ595179	piR-hsa-25440	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ595179 may correlated with the increased risk of Bladder carcinoma.
PIRP00000372	25998508	piR-32986	piR-hsa-13197	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-32986 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000373	27323410	piR-35855	piR-hsa-28019	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-35855 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000374	25305452	DQ596466	piR-hsa-26682	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ596466 may correlated with the increased risk of Bladder carcinoma.
PIRP00000375	25305452	DQ593888	piR-hsa-22915	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ593888 may correlated with the increased risk of Bladder carcinoma.
PIRP00000376	25305452	DQ599458	piR-hsa-29715	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ599458 may correlated with the increased risk of Bladder carcinoma.
PIRP00000376	27323410	piR-37524	piR-hsa-29715	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-37524 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000377	27429044	hsa_piR_009051	piR-hsa-12487	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_009051 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000378	27323410	piR-36038	piR-hsa-28187	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36038 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000379	25305452	DQ599459	piR-hsa-29716	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ599459 may correlated with the increased risk of Bladder carcinoma.
PIRP00000379	27323410	piR-37525	piR-hsa-29716	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-37525 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000380	27323410	piR-36039	piR-hsa-28188	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36039 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000381	25305452	DQ596468	piR-hsa-26684	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ596468 may correlated with the increased risk of Bladder carcinoma.
PIRP00000382	25305452	DQ571055	piR-hsa-1306	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ571055 may correlated with the increased risk of Bladder carcinoma.
PIRP00000383	28423657	piR-52200	piR-hsa-15399	Breast carcinoma	EFO:0000305	upregulation	increased risk	breast cancer cell lines	N/A	N/A	AMPK signaling pathway	0.05	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-52200 may correlated with the increased risk of Breast carcinoma.
PIRP00000384	27323410	piR-36040	piR-hsa-28189	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36040 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000385	27429044	hsa_piR_011901	piR-hsa-16348	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_011901 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000386	25305452	DQ570392	piR-hsa-672	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ570392 may correlated with the increased risk of Bladder carcinoma.
PIRP00000387	25779424	FR290353	FR290353	Gastric carcinoma	EFO:0000178	upregulation	poor progonosis	gastric cancer recurrence	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Gastric carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of FR290353 may correlated with the poor progonosis of Gastric carcinoma.
PIRP00000388	25305452	DQ593538	piR-hsa-23786	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ593538 may correlated with the increased risk of Bladder carcinoma.
PIRP00000388	27429044	hsa_piR_017033	piR-hsa-23786	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_017033 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000389	25305452	DQ570394	piR-hsa-674	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ570394 may correlated with the increased risk of Bladder carcinoma.
PIRP00000390	27323410	piR-34456	piR-hsa-26606	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-34456 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000391	21616063	piR-651	piR-hsa-1077	Breast carcinoma	EFO:0000305	upregulation	increased risk	breast cancer tissues	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-651 may correlated with the increased risk of Breast carcinoma.
PIRP00000391	21616063	piR-651	piR-hsa-1077	Gastric carcinoma	EFO:0000178	upregulation	increased risk and poor progonosis	gastric cancer and  gastric cancer cell lines	N/A	N/A	Cell proliferation	0.40	The piRNAs dysregulation associated with Gastric carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Gastric carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-651 may correlated with the increased risk and poor progonosis of Gastric carcinoma. Moreover, both molecular functions and physiological functions of piR-651 involving in the pathologies of Gastric carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-651 is possibly correlated with the increased risk and poor progonosis of Gastric carcinoma.
PIRP00000391	21616063	piR-651	piR-hsa-1077	Lung carcinoma	EFO:0001071	upregulation	increased risk	lung cancer tissues	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Lung carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-651 may correlated with the increased risk of Lung carcinoma.
PIRP00000391	26071182	piR-30924	piR-hsa-1077	Clear cell renal cell carcinomas	EFO:0000349	upregulation	poor progonosis	clear cell renal cell carcinomas patients	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Clear cell renal cell carcinomas was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Clear cell renal cell carcinomas was validated by RT-PCR. The validated results indicated that the upregulation of piR-30924 may correlated with the poor progonosis of Clear cell renal cell carcinomas.
PIRP00000391	27414029	piR-651	piR-hsa-1077	Breast carcinoma	EFO:0000305	upregulation	decreased risk	breast cancer cell lines	hormone treatment	N/A	Cell proliferation and EMT signaling pathway	-0.2	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-651 may correlated with the decreased risk of Breast carcinoma. Moreover, the molecular functions or physiological functions of piR-651 involving in the pathologies of Breast carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-651 is possibly correlated with the decreased risk of Breast carcinoma.
PIRP00000391	27414029	piR-651	piR-hsa-1077	Pancreatic carcinoma	EFO:0002618	upregulation	decreased risk	prostate cancer cell lines	hormone treatment	N/A	Cell proliferation and EMT signaling pathway	-0.2	The piRNAs dysregulation associated with Pancreatic carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Pancreatic carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-651 may correlated with the decreased risk of Pancreatic carcinoma. Moreover, the molecular functions or physiological functions of piR-651 involving in the pathologies of Pancreatic carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-651 is possibly correlated with the decreased risk of Pancreatic carcinoma.
PIRP00000392	27323410	piR-61298	piR-hsa-25447	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-61298 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000393	25305452	DQ591339	piR-hsa-21604	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ591339 may correlated with the increased risk of Bladder carcinoma.
PIRP00000394	25305452	DQ599177	piR-hsa-29448	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ599177 may correlated with the increased risk of Bladder carcinoma.
PIRP00000395	28654860	piR-hsa-28908	piR-hsa-28908	Alzheimer's disease	EFO:0000249	downregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-hsa-28908 may correlated with the increased risk of Alzheimer's disease.
PIRP00000396	25305452	DQ590027	piR-hsa-20280	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ590027 may correlated with the increased risk of Bladder carcinoma.
PIRP00000397	29460056	DQ579754	piR-hsa-10009	Azoospermia	EFO:0000279	downregulation	increased risk	patients with nonobstructive azoospermia (NOA) between successful and unsuccessful sperm retrieval before micro-dissection testicular sperm extraction (micro-TESE)	N/A	N/A	Cell apoptosis, cell proliferation, and cell differentiation	-0.1	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of DQ579754 may correlated with the increased risk of Azoospermia.
PIRP00000398	25305452	DQ592048	piR-hsa-22296	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ592048 may correlated with the increased risk of Bladder carcinoma.
PIRP00000399	25305452	DQ590028	piR-hsa-20281	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ590028 may correlated with the increased risk of Bladder carcinoma.
PIRP00000400	25305452	DQ590029	piR-hsa-20282	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ590029 may correlated with the increased risk of Bladder carcinoma.
PIRP00000401	28654860	piR-hsa-9851	piR-hsa-9851	Alzheimer's disease	EFO:0000249	downregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-hsa-9851 may correlated with the increased risk of Alzheimer's disease.
PIRP00000402	27323410	piR-35221	piR-hsa-27124	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-35221 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000403	25305452	DQ590030	piR-hsa-20283	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ590030 may correlated with the increased risk of Bladder carcinoma.
PIRP00000404	28651359	DQ597916	piR-hsa-28131	Diminished ovarian reserve	EFO:0004770	downregulation	increased risk	patients with diminished ovarian reserve	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Diminished ovarian reserve was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Diminished ovarian reserve was validated by RT-PCR. The validated results indicated that the downregulation of DQ597916 may correlated with the increased risk of Diminished ovarian reserve.
PIRP00000405	25305452	DQ590031	piR-hsa-20284	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ590031 may correlated with the increased risk of Bladder carcinoma.
PIRP00000406	28651359	DQ598273	piR-hsa-28488	Diminished ovarian reserve	EFO:0004770	upregulation	increased risk	patients with diminished ovarian reserve	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Diminished ovarian reserve was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ598273 may correlated with the increased risk of Diminished ovarian reserve.
PIRP00000407	27323410	piR-34291	piR-hsa-26441	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-34291 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000408	25305452	DQ590335	piR-hsa-20559	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ590335 may correlated with the increased risk of Bladder carcinoma.
PIRP00000409	25305452	DQ577459	piR-hsa-7734	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ577459 may correlated with the increased risk of Bladder carcinoma.
PIRP00000410	25305452	DQ576844	piR-hsa-7180	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ576844 may correlated with the increased risk of Bladder carcinoma.
PIRP00000411	28654860	piR-hsa-21131	piR-hsa-21131	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-21131 may correlated with the increased risk of Alzheimer's disease.
PIRP00000412	25305452	DQ575973	piR-hsa-6236	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ575973 may correlated with the increased risk of Bladder carcinoma.
PIRP00000413	26148798	DQ582264	piR-hsa-12487	Asthma	EFO:0000270	upregulation	increased risk	asthmatic patientss	N/A	N/A	Akt signaling pathway	0.10	The piRNAs dysregulation associated with Asthma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Asthma was validated by RT-PCR. The validated results indicated that the upregulation of DQ582264 may correlated with the increased risk of Asthma.
PIRP00000414	25305452	DQ584252	piR-hsa-14474	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ584252 may correlated with the increased risk of Bladder carcinoma.
PIRP00000415	27323410	piR-62011	piR-hsa-26131	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-62011 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000416	25305452	DQ572459	piR-hsa-2695	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ572459 may correlated with the increased risk of Bladder carcinoma.
PIRP00000417	25305452	DQ585043	piR-hsa-15354	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ585043 may correlated with the increased risk of Bladder carcinoma.
PIRP00000418	28654860	piR-hsa-26293	piR-hsa-26293	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-26293 may correlated with the increased risk of Alzheimer's disease.
PIRP00000419	23229900	piR-4987	piR-hsa-7193	Breast carcinoma	EFO:0000305	upregulation	increased risk and poor progonosis	resected breast cancer cases	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-4987 may correlated with the increased risk and poor progonosis of Breast carcinoma.
PIRP00000419	27429044	hsa_piR_004987	piR-hsa-7193	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_004987 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000420	25305452	DQ576078	piR-hsa-6341	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ576078 may correlated with the increased risk of Bladder carcinoma.
PIRP00000421	25998508	piR-54436	piR-hsa-17615	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-54436 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000422	28654860	piR-hsa-10501	piR-hsa-10501	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-10501 may correlated with the increased risk of Alzheimer's disease.
PIRP00000423	25305452	DQ597765	piR-hsa-27995	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ597765 may correlated with the increased risk of Bladder carcinoma.
PIRP00000424	25305452	DQ582294	piR-hsa-12517	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ582294 may correlated with the increased risk of Bladder carcinoma.
PIRP00000425	28423657	piR-52200	piR-hsa-15399	Breast carcinoma	EFO:0000305	upregulation	increased risk	breast cancer cell lines	N/A	N/A	AMPK signaling pathway	0.05	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-52200 may correlated with the increased risk of Breast carcinoma.
PIRP00000425	28423657	piR-52200	piR-hsa-15399	Lung carcinoma	EFO:0001071	upregulation	increased risk	lung cancer patients and lung cancer cell lines	N/A	AMPK	AMPK signaling pathway	0.40	The piRNAs dysregulation associated with Lung carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-52200 may correlated with the increased risk of Lung carcinoma. Moreover, both molecular functions and physiological functions of piR-52200 involving in the pathologies of Lung carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-52200 is possibly correlated with the increased risk of Lung carcinoma.
PIRP00000426	27429044	hsa_piR_012681	piR-hsa-17444	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_012681 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000427	25305452	DQ577000	piR-hsa-7319	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ577000 may correlated with the increased risk of Bladder carcinoma.
PIRP00000428	25305452	DQ579883	piR-hsa-10123	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ579883 may correlated with the increased risk of Bladder carcinoma.
PIRP00000429	27323410	piR-34291	piR-hsa-26441	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-34291 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000429	27429044	hsa_piR_019102	piR-hsa-26441	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_019102 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000429	27829231	DQ596225	piR-hsa-26441	Lung adenocarcinoma	EFO:0000571	upregulation	poor progonosis	lung adenocarcinoma samples	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Lung adenocarcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung adenocarcinoma was validated by RT-PCR. The validated results indicated that the upregulation of DQ596225 may correlated with the poor progonosis of Lung adenocarcinoma.
PIRP00000430	25740697	piR-015551	piR-hsa-21517	Colorectal cancer	EFO:0005842	rs11776042	decreased risk	colorectal cancer 	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Colorectal cancer was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Colorectal cancer was validated by RT-PCR. The validated results indicated that the rs11776042 of piR-015551 may correlated with the decreased risk of Colorectal cancer.
PIRP00000431	25305452	DQ586998	piR-hsa-17304	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ586998 may correlated with the increased risk of Bladder carcinoma.
PIRP00000432	25305452	DQ570485	piR-hsa-765	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ570485 may correlated with the increased risk of Bladder carcinoma.
PIRP00000433	25305452	DQ581967	piR-hsa-12206	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ581967 may correlated with the increased risk of Bladder carcinoma.
PIRP00000434	25305452	DQ596466	piR-hsa-26682	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ596466 may correlated with the increased risk of Bladder carcinoma.
PIRP00000435	25305452	DQ593888	piR-hsa-22915	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ593888 may correlated with the increased risk of Bladder carcinoma.
PIRP00000436	28654860	piR-hsa-14547	piR-hsa-14547	Alzheimer's disease	EFO:0000249	downregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-hsa-14547 may correlated with the increased risk of Alzheimer's disease.
PIRP00000437	27429044	hsa_piR_001170	piR-hsa-1849	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_001170 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000438	28654860	piR-hsa-25985	piR-hsa-25985	Alzheimer's disease	EFO:0000249	downregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-hsa-25985 may correlated with the increased risk of Alzheimer's disease.
PIRP00000439	25305452	DQ596468	piR-hsa-26684	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ596468 may correlated with the increased risk of Bladder carcinoma.
PIRP00000440	26148798	DQ595186	piR-hsa-25447	Asthma	EFO:0000270	upregulation	increased risk	asthmatic patientss	N/A	N/A	Akt signaling pathway	0.10	The piRNAs dysregulation associated with Asthma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Asthma was validated by RT-PCR. The validated results indicated that the upregulation of DQ595186 may correlated with the increased risk of Asthma.
PIRP00000441	25305452	DQ570485	piR-hsa-765	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ570485 may correlated with the increased risk of Bladder carcinoma.
PIRP00000442	27323410	piR-62011	piR-hsa-26131	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-62011 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000443	25305452	DQ570324	piR-hsa-180	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ570324 may correlated with the increased risk of Bladder carcinoma.
PIRP00000444	29460056	DQ593626	piR-hsa-23874	Azoospermia	EFO:0000279	downregulation	increased risk	patients with nonobstructive azoospermia (NOA) between successful and unsuccessful sperm retrieval before micro-dissection testicular sperm extraction (micro-TESE)	N/A	N/A	Cell apoptosis, cell proliferation, and cell differentiation	-0.1	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of DQ593626 may correlated with the increased risk of Azoospermia.
PIRP00000445	27197292	piR-3266	piR-hsa-4668	Glioma	EFO:0005543	rs35712968	decreased risk	glioma cell	N/A	N/A	N/A	0.20	The piRNAs dysregulation associated with Glioma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Glioma was validated by RT-PCR. The validated results indicated that the rs35712968 of piR-3266 may correlated with the decreased risk of Glioma. Moreover, the molecular functions or physiological functions of piR-3266 involving in the pathologies of Glioma are illustrated in cell lines in vitro. Altogether, all above results suggested that the rs35712968 of piR-3266 is possibly correlated with the decreased risk of Glioma.
PIRP00000446	27323410	piR-33044	piR-hsa-23210	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-33044 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000447	26408181	piR-55490	piR-hsa-9	Lung carcinoma	EFO:0001071	downregulation	increased risk	lung cancer cells	N/A	mTOR	Akt/mTOR signaling pathway	-0.8	The piRNAs dysregulation associated with Lung carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of piR-55490 may correlated with the increased risk of Lung carcinoma. Moreover, both molecular functions, physiological functions and/or mechanisms of piR-55490 involving in the pathologies of Lung carcinoma are illustrated in cell lines in vitro. Furthermore, the animal model experiments in vivo (eg. xenograft, transgenic) also demonstrated and supported the piR-55490 dysregulation associated with the pathologies of Lung carcinoma. Altogether, all above results suggested that the downregulation of piR-55490 is possibly correlated with the increased risk of Lung carcinoma.
PIRP00000448	27323410	piR-49143	piR-hsa-11360	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-49143 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000449	27323410	piR-49144	piR-hsa-11361	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-49144 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000450	25305452	DQ598548	piR-hsa-28749	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ598548 may correlated with the increased risk of Bladder carcinoma.
PIRP00000451	25305452	DQ570324	piR-hsa-180	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ570324 may correlated with the increased risk of Bladder carcinoma.
PIRP00000452	25305452	DQ597293	piR-hsa-27568	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ597293 may correlated with the increased risk of Bladder carcinoma.
PIRP00000453	25305452	DQ593305	piR-hsa-23568	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ593305 may correlated with the increased risk of Bladder carcinoma.
PIRP00000454	27323410	piR-49145	piR-hsa-11362	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-49145 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00000454	28109471	piR-49145	piR-hsa-11362	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-49145 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00000455	25305452	DQ595292	piR-hsa-25553	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ595292 may correlated with the increased risk of Bladder carcinoma.
PIRP00000456	25305452	DQ598918	piR-hsa-29218	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ598918 may correlated with the increased risk of Bladder carcinoma.
PIRP00000457	25305452	DQ584635	piR-hsa-14960	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ584635 may correlated with the increased risk of Bladder carcinoma.
PIRP00000458	27197292	piR-2799	piR-hsa-4045	Glioma	EFO:0005543	rs149336947	increased risk	glioma cell	N/A	N/A	N/A	-0.2	The piRNAs dysregulation associated with Glioma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Glioma was validated by RT-PCR. The validated results indicated that the rs149336947 of piR-2799 may correlated with the increased risk of Glioma. Moreover, the molecular functions or physiological functions of piR-2799 involving in the pathologies of Glioma are illustrated in cell lines in vitro. Altogether, all above results suggested that the rs149336947 of piR-2799 is possibly correlated with the increased risk of Glioma.
PIRP00000459	27323410	piR-41794	piR-hsa-3961	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-41794 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000460	25305452	DQ592938	piR-hsa-23216	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ592938 may correlated with the increased risk of Bladder carcinoma.
PIRP00000460	27429044	hsa_piR_016664	piR-hsa-23216	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_016664 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000461	27429044	hsa_piR_017295	piR-hsa-24143	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_017295 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000462	25740697	piR-015551	piR-hsa-21517	Colorectal cancer	EFO:0005842	rs11776042	decreased risk	colorectal cancer 	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Colorectal cancer was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Colorectal cancer was validated by RT-PCR. The validated results indicated that the rs11776042 of piR-015551 may correlated with the decreased risk of Colorectal cancer.
PIRP00000463	25305452	DQ591007	piR-hsa-21286	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ591007 may correlated with the increased risk of Bladder carcinoma.
PIRP00000464	27323410	piR-31355	piR-hsa-1580	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-31355 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000465	25305452	DQ583545	piR-hsa-13825	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ583545 may correlated with the increased risk of Bladder carcinoma.
PIRP00000466	29460056	DQ573385	piR-hsa-3678	Azoospermia	EFO:0000279	downregulation	increased risk	patients with nonobstructive azoospermia (NOA) between successful and unsuccessful sperm retrieval before micro-dissection testicular sperm extraction (micro-TESE)	N/A	N/A	Cell apoptosis, cell proliferation, and cell differentiation	-0.1	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of DQ573385 may correlated with the increased risk of Azoospermia.
PIRP00000467	25305452	DQ589839	piR-hsa-20107	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ589839 may correlated with the increased risk of Bladder carcinoma.
PIRP00000468	23229900	piR-4987	piR-hsa-7193	Breast carcinoma	EFO:0000305	upregulation	increased risk and poor progonosis	resected breast cancer cases	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-4987 may correlated with the increased risk and poor progonosis of Breast carcinoma.
PIRP00000469	27429044	hsa_piR_001170	piR-hsa-1849	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_001170 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000470	25305452	DQ581827	piR-hsa-12081	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ581827 may correlated with the increased risk of Bladder carcinoma.
PIRP00000471	25305452	DQ581488	piR-hsa-11773	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ581488 may correlated with the increased risk of Bladder carcinoma.
PIRP00000472	25305452	DQ586065	piR-hsa-16315	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ586065 may correlated with the increased risk of Bladder carcinoma.
PIRP00000473	25305452	DQ593702	piR-hsa-23950	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ593702 may correlated with the increased risk of Bladder carcinoma.
PIRP00000474	25998508	piR-34434	piR-hsa-26584	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-34434 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000475	25305452	DQ571140	piR-hsa-1477	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ571140 may correlated with the increased risk of Bladder carcinoma.
PIRP00000476	25305452	DQ571021	piR-hsa-1272	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ571021 may correlated with the increased risk of Bladder carcinoma.
PIRP00000477	29460056	DQ586061	piR-hsa-16311	Azoospermia	EFO:0000279	downregulation	increased risk	patients with nonobstructive azoospermia (NOA) between successful and unsuccessful sperm retrieval before micro-dissection testicular sperm extraction (micro-TESE)	N/A	N/A	Cell apoptosis, cell proliferation, and cell differentiation	-0.1	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of DQ586061 may correlated with the increased risk of Azoospermia.
PIRP00000478	25998508	piR-32105	piR-hsa-12232	Renal cell carcinoma	EFO:0000681	upregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-32105 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000479	27323410	piR-35466	piR-hsa-27137	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-35466 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00000480	25305452	DQ600951	piR-hsa-31237	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ600951 may correlated with the increased risk of Bladder carcinoma.
PIRP00000481	25305452	DQ597765	piR-hsa-27995	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ597765 may correlated with the increased risk of Bladder carcinoma.
PIRP00000482	25305452	DQ582294	piR-hsa-12517	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ582294 may correlated with the increased risk of Bladder carcinoma.
PIRP00000483	27323410	piR-35467	piR-hsa-27138	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-35467 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00000484	27323410	piR-54907	piR-hsa-18071	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-54907 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000485	25305452	DQ600952	piR-hsa-31238	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ600952 may correlated with the increased risk of Bladder carcinoma.
PIRP00000486	27429044	hsa_piR_020828	piR-hsa-28875	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_020828 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000487	27323410	piR-35468	piR-hsa-27139	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-35468 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00000488	28654860	piR-hsa-11231	piR-hsa-11231	Alzheimer's disease	EFO:0000249	downregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-hsa-11231 may correlated with the increased risk of Alzheimer's disease.
PIRP00000489	25313140	DQ598677	piR-hsa-28877	Breast carcinoma	EFO:0000305	upregulation	increased risk	breast cancer	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of DQ598677 may correlated with the increased risk of Breast carcinoma.
PIRP00000489	27429044	hsa_piR_020829	piR-hsa-28877	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_020829 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000490	25305452	DQ596660	piR-hsa-26862	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596660 may correlated with the increased risk of Bladder carcinoma.
PIRP00000491	25305452	DQ581096	piR-hsa-11425	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ581096 may correlated with the increased risk of Bladder carcinoma.
PIRP00000492	25305452	DQ581967	piR-hsa-12206	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ581967 may correlated with the increased risk of Bladder carcinoma.
PIRP00000493	28654860	piR-hsa-13701	piR-hsa-13701	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-13701 may correlated with the increased risk of Alzheimer's disease.
PIRP00000494	24247010	DQ598918	piR-hsa-29218	Testicular neoplasm	EFO:0004281	downregulation	increased risk	primary testicular tumors	N/A	N/A	N/A	-0.2	The piRNAs dysregulation associated with Testicular neoplasm was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Testicular neoplasm was validated by RT-PCR. The validated results indicated that the downregulation of DQ598918 may correlated with the increased risk of Testicular neoplasm. Moreover, the molecular functions or physiological functions of DQ598918 involving in the pathologies of Testicular neoplasm are illustrated in cell lines in vitro. Altogether, all above results suggested that the downregulation of DQ598918 is possibly correlated with the increased risk of Testicular neoplasm.
PIRP00000495	29382334	piR-1245	piR-hsa-1963	Renal carcinoma	EFO:0002890	upregulation	increased risk	kidney cancer patients	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Renal carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-1245 may correlated with the increased risk of Renal carcinoma.
PIRP00000496	27323410	piR-34440	piR-hsa-26590	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-34440 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000497	25305452	DQ591460	piR-hsa-21724	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ591460 may correlated with the increased risk of Bladder carcinoma.
PIRP00000498	27429044	hsa_piR_020809	piR-hsa-28839	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_020809 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000499	28654860	piR-hsa-28025	piR-hsa-28025	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-28025 may correlated with the increased risk of Alzheimer's disease.
PIRP00000500	23229900	piR-20485	piR-hsa-28374	Breast carcinoma	EFO:0000305	upregulation	increased risk	resected breast cancer cases	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-20485 may correlated with the increased risk of Breast carcinoma.
PIRP00000501	27429044	hsa_piR_008033	piR-hsa-11256	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_008033 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000502	25305452	DQ570657	piR-hsa-922	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ570657 may correlated with the increased risk of Bladder carcinoma.
PIRP00000503	25305452	DQ591339	piR-hsa-21604	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ591339 may correlated with the increased risk of Bladder carcinoma.
PIRP00000504	23229900	piR-20582	piR-hsa-28527	Breast carcinoma	EFO:0000305	upregulation	increased risk	resected breast cancer cases	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-20582 may correlated with the increased risk of Breast carcinoma.
PIRP00000505	29460056	DQ598679	piR-hsa-28879	Azoospermia	EFO:0000279	downregulation	increased risk	patients with nonobstructive azoospermia (NOA) between successful and unsuccessful sperm retrieval before micro-dissection testicular sperm extraction (micro-TESE)	N/A	N/A	Cell apoptosis, cell proliferation, and cell differentiation	-0.1	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of DQ598679 may correlated with the increased risk of Azoospermia.
PIRP00000506	25305452	DQ597833	piR-hsa-28063	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ597833 may correlated with the increased risk of Bladder carcinoma.
PIRP00000507	27429044	hsa_piR_016240	piR-hsa-22382	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_016240 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000508	25313140	DQ597960	piR-hsa-28175	Breast carcinoma	EFO:0000305	upregulation	increased risk	breast cancer	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of DQ597960 may correlated with the increased risk of Breast carcinoma.
PIRP00000508	27289065	piR-36026	piR-hsa-28175	Breast carcinoma	EFO:0000305	upregulation	increased risk and poor progonosis	MCF-7 breast cancer cell line	N/A	SERPINA1; LRAT; Caspase-3	Cell appoptosis	0.80	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-36026 may correlated with the increased risk and poor progonosis of Breast carcinoma. Moreover, both molecular functions, physiological functions and/or mechanisms of piR-36026 involving in the pathologies of Breast carcinoma are illustrated in cell lines in vitro. Furthermore, the animal model experiments in vivo (eg. xenograft, transgenic) also demonstrated and supported the piR-36026 dysregulation associated with the pathologies of Breast carcinoma. Altogether, all above results suggested that the upregulation of piR-36026 is possibly correlated with the increased risk and poor progonosis of Breast carcinoma.
PIRP00000509	28654860	piR-hsa-27400	piR-hsa-27400	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-27400 may correlated with the increased risk of Alzheimer's disease.
PIRP00000510	25305452	DQ596300	piR-hsa-26516	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596300 may correlated with the increased risk of Bladder carcinoma.
PIRP00000511	27429044	hsa_piR_021190	piR-hsa-29417	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_021190 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000512	27323410	piR-41794	piR-hsa-3961	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-41794 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000513	27323410	piR-54265	piR-hsa-17444	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-54265 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000514	28423657	piR-35127	piR-hsa-27351	Lung carcinoma	EFO:0001071	downregulation	increased risk	lung cancer patients and lung cancer cell lines	N/A	AMPK	AMPK signaling pathway	-0.4	The piRNAs dysregulation associated with Lung carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of piR-35127 may correlated with the increased risk of Lung carcinoma. Moreover, both molecular functions and physiological functions of piR-35127 involving in the pathologies of Lung carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the downregulation of piR-35127 is possibly correlated with the increased risk of Lung carcinoma.
PIRP00000515	28109471	NONHSAT067200	NONHSAT067200	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	tobacco	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of NONHSAT067200 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00000516	25305452	DQ581730	piR-hsa-11984	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ581730 may correlated with the increased risk of Bladder carcinoma.
PIRP00000517	27323410	piR-36711	piR-hsa-28845	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-36711 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000518	25998508	piR-54403	piR-hsa-17582	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-54403 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000519	28654860	piR-hsa-27489	piR-hsa-27489	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-27489 may correlated with the increased risk of Alzheimer's disease.
PIRP00000520	28654860	piR-hsa-27133	piR-hsa-27133	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-27133 may correlated with the increased risk of Alzheimer's disease.
PIRP00000521	25305452	DQ588363	piR-hsa-18594	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ588363 may correlated with the increased risk of Bladder carcinoma.
PIRP00000522	27323410	piR-36712	piR-hsa-28846	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-36712 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000523	25305452	DQ583545	piR-hsa-13825	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ583545 may correlated with the increased risk of Bladder carcinoma.
PIRP00000524	27323410	piR-36338	piR-hsa-28487	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36338 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000525	28654860	piR-hsa-27134	piR-hsa-27134	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-27134 may correlated with the increased risk of Alzheimer's disease.
PIRP00000526	23376363	piR-Hep1	piR-hsa-8438265	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	hepatocellular carcinoma patients and  hepatocellular lines	N/A	Akt	Akt signaling pathway	0.40	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Hepatocellular carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-Hep1 may correlated with the increased risk of Hepatocellular carcinoma. Moreover, both molecular functions and physiological functions of piR-Hep1 involving in the pathologies of Hepatocellular carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-Hep1 is possibly correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000527	27323410	piR-36713	piR-hsa-28847	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36713 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000528	29460056	DQ593626	piR-hsa-23874	Azoospermia	EFO:0000279	downregulation	increased risk	patients with nonobstructive azoospermia (NOA) between successful and unsuccessful sperm retrieval before micro-dissection testicular sperm extraction (micro-TESE)	N/A	N/A	Cell apoptosis, cell proliferation, and cell differentiation	-0.1	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of DQ593626 may correlated with the increased risk of Azoospermia.
PIRP00000529	25305452	DQ589839	piR-hsa-20107	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ589839 may correlated with the increased risk of Bladder carcinoma.
PIRP00000530	27919963	piR-823	piR-hsa-1282	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	patientss with Renal Cell Carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-823 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000531	25998508	piR-43607	piR-hsa-5773	Renal cell carcinoma	EFO:0000681	upregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	0.20	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Renal cell carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-43607 may correlated with the increased risk and poor progonosis of Renal cell carcinoma. Moreover, the molecular functions or physiological functions of piR-43607 involving in the pathologies of Renal cell carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-43607 is possibly correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000532	27323410	piR-36714	piR-hsa-28848	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36714 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000533	28654860	piR-hsa-6740	piR-hsa-6740	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-6740 may correlated with the increased risk of Alzheimer's disease.
PIRP00000534	27323410	piR-36340	piR-hsa-28489	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36340 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000535	25305452	DQ584252	piR-hsa-14474	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ584252 may correlated with the increased risk of Bladder carcinoma.
PIRP00000536	27323410	piR-36715	piR-hsa-28849	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36715 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000537	26071182	piR-30924	piR-hsa-1077	Clear cell renal cell carcinomas	EFO:0000349	upregulation	poor progonosis	clear cell renal cell carcinomas patients	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Clear cell renal cell carcinomas was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Clear cell renal cell carcinomas was validated by RT-PCR. The validated results indicated that the upregulation of piR-30924 may correlated with the poor progonosis of Clear cell renal cell carcinomas.
PIRP00000538	27323410	piR-49143	piR-hsa-11360	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-49143 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000539	25998508	piR-64616	piR-rno-50934	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-64616 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000540	28654860	piR-hsa-27138	piR-hsa-27138	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-27138 may correlated with the increased risk of Alzheimer's disease.
PIRP00000541	27323410	piR-49144	piR-hsa-11361	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-49144 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000542	25779424	FR157678	FR157678	Gastric carcinoma	EFO:0000178	upregulation	poor progonosis	gastric cancer recurrence	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Gastric carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of FR157678 may correlated with the poor progonosis of Gastric carcinoma.
PIRP00000543	28654860	piR-hsa-27139	piR-hsa-27139	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-27139 may correlated with the increased risk of Alzheimer's disease.
PIRP00000544	27323410	piR-49145	piR-hsa-11362	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-49145 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00000544	28109471	piR-49145	piR-hsa-11362	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-49145 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00000545	28423657	piR-34871	piR-hsa-27007	Lung carcinoma	EFO:0001071	upregulation	increased risk	lung cancer patients and lung cancer cell lines	N/A	AMPK	AMPK signaling pathway	0.40	The piRNAs dysregulation associated with Lung carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-34871 may correlated with the increased risk of Lung carcinoma. Moreover, both molecular functions and physiological functions of piR-34871 involving in the pathologies of Lung carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-34871 is possibly correlated with the increased risk of Lung carcinoma.
PIRP00000546	27323410	piR-36074	piR-hsa-28223	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-36074 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000547	28651359	DQ571031	piR-hsa-1282	Diminished ovarian reserve	EFO:0004770	upregulation	increased risk	patients with diminished ovarian reserve	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Diminished ovarian reserve was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ571031 may correlated with the increased risk of Diminished ovarian reserve.
PIRP00000548	27429044	hsa_piR_013306	piR-hsa-18287	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_013306 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000549	25305452	DQ579883	piR-hsa-10123	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ579883 may correlated with the increased risk of Bladder carcinoma.
PIRP00000550	25313140	DQ596670	piR-hsa-26872	Breast carcinoma	EFO:0000305	downregulation	increased risk	breast cancer	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of DQ596670 may correlated with the increased risk of Breast carcinoma.
PIRP00000551	25305452	DQ600951	piR-hsa-31237	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ600951 may correlated with the increased risk of Bladder carcinoma.
PIRP00000552	25305452	DQ575973	piR-hsa-6236	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ575973 may correlated with the increased risk of Bladder carcinoma.
PIRP00000553	25305452	DQ600952	piR-hsa-31238	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ600952 may correlated with the increased risk of Bladder carcinoma.
PIRP00000554	28654860	piR-hsa-4000	piR-hsa-4000	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-4000 may correlated with the increased risk of Alzheimer's disease.
PIRP00000555	25305452	DQ585901	piR-hsa-16151	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ585901 may correlated with the increased risk of Bladder carcinoma.
PIRP00000556	25305452	DQ571998	piR-hsa-2278	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ571998 may correlated with the increased risk of Bladder carcinoma.
PIRP00000557	25305452	DQ570901	piR-hsa-1152	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ570901 may correlated with the increased risk of Bladder carcinoma.
PIRP00000558	25910082	piR-017061	piR-hsa-23822	Pancreatic carcinoma	EFO:0002618	downregulation	increased risk	pancreatic cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Pancreatic carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-017061 may correlated with the increased risk of Pancreatic carcinoma.
PIRP00000558	27429044	hsa_piR_017061	piR-hsa-23822	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_017061 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000559	25305452	DQ593888	piR-hsa-22915	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ593888 may correlated with the increased risk of Bladder carcinoma.
PIRP00000560	25305452	DQ571849	piR-hsa-2129	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ571849 may correlated with the increased risk of Bladder carcinoma.
PIRP00000561	25998508	piR-54542	piR-hsa-17720	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-54542 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000562	25305452	DQ593618	piR-hsa-23866	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ593618 may correlated with the increased risk of Bladder carcinoma.
PIRP00000563	25305452	DQ591460	piR-hsa-21724	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ591460 may correlated with the increased risk of Bladder carcinoma.
PIRP00000564	27197292	piR-598	piR-hsa-1006	Glioma	EFO:0005543	rs147061479	increased risk	glioma cell	N/A	N/A	Cell proliferation	-0.4	The piRNAs dysregulation associated with Glioma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Glioma was validated by RT-PCR. The validated results indicated that the rs147061479 of piR-598 may correlated with the increased risk of Glioma. Moreover, both molecular functions and physiological functions of piR-598 involving in the pathologies of Glioma are illustrated in cell lines in vitro. Altogether, all above results suggested that the rs147061479 of piR-598 is possibly correlated with the increased risk of Glioma.
PIRP00000565	28654860	piR-hsa-20752	piR-hsa-20752	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-20752 may correlated with the increased risk of Alzheimer's disease.
PIRP00000566	25305452	DQ597622	piR-hsa-27867	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ597622 may correlated with the increased risk of Bladder carcinoma.
PIRP00000567	25305452	DQ593289	piR-hsa-23552	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ593289 may correlated with the increased risk of Bladder carcinoma.
PIRP00000568	27429044	hsa_piR_016970	piR-hsa-23655	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_016970 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000569	28651359	DQ598675	piR-hsa-28875	Diminished ovarian reserve	EFO:0004770	upregulation	increased risk	patients with diminished ovarian reserve	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Diminished ovarian reserve was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ598675 may correlated with the increased risk of Diminished ovarian reserve.
PIRP00000570	25305452	DQ593621	piR-hsa-23869	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ593621 may correlated with the increased risk of Bladder carcinoma.
PIRP00000571	27429044	hsa_piR_017791	piR-hsa-24775	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_017791 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000572	28651359	DQ598677	piR-hsa-28877	Diminished ovarian reserve	EFO:0004770	upregulation	increased risk	patients with diminished ovarian reserve	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Diminished ovarian reserve was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ598677 may correlated with the increased risk of Diminished ovarian reserve.
PIRP00000573	27197292	piR-11714	piR-hsa-16119	Glioma	EFO:0005543	rs142742690	decreased risk	glioma cell	N/A	N/A	N/A	0.20	The piRNAs dysregulation associated with Glioma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Glioma was validated by RT-PCR. The validated results indicated that the rs142742690 of piR-11714 may correlated with the decreased risk of Glioma. Moreover, the molecular functions or physiological functions of piR-11714 involving in the pathologies of Glioma are illustrated in cell lines in vitro. Altogether, all above results suggested that the rs142742690 of piR-11714 is possibly correlated with the decreased risk of Glioma.
PIRP00000574	25305452	DQ596282	piR-hsa-26498	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596282 may correlated with the increased risk of Bladder carcinoma.
PIRP00000575	25313140	DQ596311	piR-hsa-26527	Breast carcinoma	EFO:0000305	downregulation	increased risk	breast cancer	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of DQ596311 may correlated with the increased risk of Breast carcinoma.
PIRP00000576	25305452	DQ597833	piR-hsa-28063	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ597833 may correlated with the increased risk of Bladder carcinoma.
PIRP00000577	27323410	piR-34736	piR-hsa-26872	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	EMT signaling pathway and cell apoptosis 	0.20	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Head and neck squamous cell carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-34736 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma. Moreover, the molecular functions or physiological functions of piR-34736 involving in the pathologies of Head and neck squamous cell carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-34736 is possibly correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00000578	23229900	piR-17458	piR-hsa-24360	Breast carcinoma	EFO:0000305	downregulation	increased risk	resected breast cancer cases	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-17458 may correlated with the increased risk of Breast carcinoma.
PIRP00000578	27323410	piR-60238	piR-hsa-24360	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-60238 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000579	25305452	DQ590938	piR-hsa-21217	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ590938 may correlated with the increased risk of Bladder carcinoma.
PIRP00000580	25305452	DQ598918	piR-hsa-29218	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ598918 may correlated with the increased risk of Bladder carcinoma.
PIRP00000581	27323410	piR-30456	piR-hsa-624	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-30456 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000582	29382334	piR-1245	piR-hsa-1963	Lung carcinoma	EFO:0001071	upregulation	increased risk	lung cancer patients and cell lines	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Lung carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-1245 may correlated with the increased risk of Lung carcinoma.
PIRP00000583	28654860	piR-hsa-20485	piR-hsa-20485	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-20485 may correlated with the increased risk of Alzheimer's disease.
PIRP00000584	25305452	DQ593256	piR-hsa-23519	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ593256 may correlated with the increased risk of Bladder carcinoma.
PIRP00000585	25779424	FR381169	FR381169	Gastric carcinoma	EFO:0000178	upregulation	poor progonosis	gastric cancer recurrence	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Gastric carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of FR381169 may correlated with the poor progonosis of Gastric carcinoma.
PIRP00000586	25305452	DQ577470	piR-hsa-7745	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ577470 may correlated with the increased risk of Bladder carcinoma.
PIRP00000587	27323410	piR-43992	piR-hsa-6143	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-43992 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000588	26071182	piR-38756	piR-hsa-30978	Clear cell renal cell carcinomas	EFO:0000349	upregulation	poor progonosis	clear cell renal cell carcinomas patients	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Clear cell renal cell carcinomas was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Clear cell renal cell carcinomas was validated by RT-PCR. The validated results indicated that the upregulation of piR-38756 may correlated with the poor progonosis of Clear cell renal cell carcinomas.
PIRP00000589	25305452	DQ576939	piR-hsa-7260	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ576939 may correlated with the increased risk of Bladder carcinoma.
PIRP00000590	25305452	DQ581730	piR-hsa-11984	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ581730 may correlated with the increased risk of Bladder carcinoma.
PIRP00000591	25305452	DQ596918	piR-hsa-27208	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ596918 may correlated with the increased risk of Bladder carcinoma.
PIRP00000592	23112866	DQ598918	piR-hsa-29218	Sertoli cell-only syndrome	EFO:1001422	downregulation	increased risk	sertoli cell-only syndrome and spermatogenic failure patients	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Sertoli cell-only syndrome was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Sertoli cell-only syndrome was validated by RT-PCR. The validated results indicated that the downregulation of DQ598918 may correlated with the increased risk of Sertoli cell-only syndrome.
PIRP00000593	28654860	piR-hsa-15247	piR-hsa-15247	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-15247 may correlated with the increased risk of Alzheimer's disease.
PIRP00000594	27323410	piR-43995	piR-hsa-6146	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-43995 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000595	25305452	DQ592931	piR-hsa-23209	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ592931 may correlated with the increased risk of Bladder carcinoma.
PIRP00000595	27323410	piR-33043	piR-hsa-23209	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-33043 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000595	28109471	piR-33043	piR-hsa-23209	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-33043 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00000596	25305452	DQ577543	piR-hsa-7817	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ577543 may correlated with the increased risk of Bladder carcinoma.
PIRP00000597	25305452	DQ588363	piR-hsa-18594	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ588363 may correlated with the increased risk of Bladder carcinoma.
PIRP00000598	25305452	DQ575764	piR-hsa-6042	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ575764 may correlated with the increased risk of Bladder carcinoma.
PIRP00000599	27323410	piR-43996	piR-hsa-6147	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-43996 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000600	28654860	piR-hsa-6740	piR-hsa-6740	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-6740 may correlated with the increased risk of Alzheimer's disease.
PIRP00000601	28654860	piR-hsa-17896	piR-hsa-17896	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-17896 may correlated with the increased risk of Alzheimer's disease.
PIRP00000602	25305452	DQ601526	piR-hsa-31766	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ601526 may correlated with the increased risk of Bladder carcinoma.
PIRP00000602	27429044	hsa_piR_023057	piR-hsa-31766	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_023057 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000603	25305452	DQ601527	piR-hsa-31767	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ601527 may correlated with the increased risk of Bladder carcinoma.
PIRP00000604	25313140	DQ596670	piR-hsa-26872	Breast carcinoma	EFO:0000305	downregulation	increased risk	breast cancer	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of DQ596670 may correlated with the increased risk of Breast carcinoma.
PIRP00000604	27323410	piR-34736	piR-hsa-26872	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	EMT signaling pathway and cell apoptosis 	0.20	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Head and neck squamous cell carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-34736 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma. Moreover, the molecular functions or physiological functions of piR-34736 involving in the pathologies of Head and neck squamous cell carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-34736 is possibly correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00000604	27429044	hsa_piR_019420	piR-hsa-26872	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_019420 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000605	27323410	piR-33880	piR-hsa-24016	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-33880 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000606	25305452	DQ593702	piR-hsa-23950	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ593702 may correlated with the increased risk of Bladder carcinoma.
PIRP00000607	29460056	DQ598679	piR-hsa-28879	Azoospermia	EFO:0000279	downregulation	increased risk	patients with nonobstructive azoospermia (NOA) between successful and unsuccessful sperm retrieval before micro-dissection testicular sperm extraction (micro-TESE)	N/A	N/A	Cell apoptosis, cell proliferation, and cell differentiation	-0.1	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of DQ598679 may correlated with the increased risk of Azoospermia.
PIRP00000608	28654860	piR-hsa-14621	piR-hsa-14621	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-14621 may correlated with the increased risk of Alzheimer's disease.
PIRP00000609	27323410	piR-33856	piR-hsa-23992	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-33856 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000610	27197292	piR-3266	piR-hsa-4668	Glioma	EFO:0005543	rs35712968	decreased risk	glioma cell	N/A	N/A	N/A	0.20	The piRNAs dysregulation associated with Glioma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Glioma was validated by RT-PCR. The validated results indicated that the rs35712968 of piR-3266 may correlated with the decreased risk of Glioma. Moreover, the molecular functions or physiological functions of piR-3266 involving in the pathologies of Glioma are illustrated in cell lines in vitro. Altogether, all above results suggested that the rs35712968 of piR-3266 is possibly correlated with the decreased risk of Glioma.
PIRP00000611	25305452	DQ588925	piR-hsa-19207	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ588925 may correlated with the increased risk of Bladder carcinoma.
PIRP00000612	25305452	DQ597765	piR-hsa-27995	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ597765 may correlated with the increased risk of Bladder carcinoma.
PIRP00000613	25305452	DQ580006	piR-hsa-10246	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ580006 may correlated with the increased risk of Bladder carcinoma.
PIRP00000614	28654860	piR-hsa-30892	piR-hsa-30892	Alzheimer's disease	EFO:0000249	downregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-hsa-30892 may correlated with the increased risk of Alzheimer's disease.
PIRP00000615	27829231	DQ596306	piR-hsa-26522	Lung adenocarcinoma	EFO:0000571	upregulation	poor progonosis	lung adenocarcinoma samples	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Lung adenocarcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung adenocarcinoma was validated by RT-PCR. The validated results indicated that the upregulation of DQ596306 may correlated with the poor progonosis of Lung adenocarcinoma.
PIRP00000616	25305452	DQ576917	piR-hsa-7238	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ576917 may correlated with the increased risk of Bladder carcinoma.
PIRP00000616	27323410	piR-45029	piR-hsa-7238	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-45029 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000616	27429044	hsa_piR_005018	piR-hsa-7238	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_005018 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000617	27429044	hsa_piR_019822	piR-hsa-27490	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_019822 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000618	25305452	DQ596307	piR-hsa-26523	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596307 may correlated with the increased risk of Bladder carcinoma.
PIRP00000619	27429044	hsa_piR_005019	piR-hsa-7239	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_005019 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000620	25305452	DQ596308	piR-hsa-26524	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596308 may correlated with the increased risk of Bladder carcinoma.
PIRP00000621	21616063	piR-651	piR-hsa-1077	Lung carcinoma	EFO:0001071	upregulation	increased risk	lung cancer tissues	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Lung carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-651 may correlated with the increased risk of Lung carcinoma.
PIRP00000622	27429044	hsa_piR_019824	piR-hsa-27492	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_019824 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000623	25305452	DQ596309	piR-hsa-26525	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596309 may correlated with the increased risk of Bladder carcinoma.
PIRP00000623	27829231	DQ596309	piR-hsa-26525	Lung adenocarcinoma	EFO:0000571	upregulation	poor progonosis	lung adenocarcinoma samples	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Lung adenocarcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung adenocarcinoma was validated by RT-PCR. The validated results indicated that the upregulation of DQ596309 may correlated with the poor progonosis of Lung adenocarcinoma.
PIRP00000624	25998508	piR-32985	piR-hsa-13196	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-32985 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000625	23229900	piR-19825	piR-hsa-27493	Breast carcinoma	EFO:0000305	upregulation	increased risk	resected breast cancer cases	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-19825 may correlated with the increased risk of Breast carcinoma.
PIRP00000625	27323410	piR-35284	piR-hsa-27493	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-35284 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000626	25305452	DQ596310	piR-hsa-26526	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596310 may correlated with the increased risk of Bladder carcinoma.
PIRP00000627	27197292	piR-2799	piR-hsa-4045	Glioma	EFO:0005543	rs149336947	increased risk	glioma cell	N/A	N/A	N/A	-0.2	The piRNAs dysregulation associated with Glioma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Glioma was validated by RT-PCR. The validated results indicated that the rs149336947 of piR-2799 may correlated with the increased risk of Glioma. Moreover, the molecular functions or physiological functions of piR-2799 involving in the pathologies of Glioma are illustrated in cell lines in vitro. Altogether, all above results suggested that the rs149336947 of piR-2799 is possibly correlated with the increased risk of Glioma.
PIRP00000628	25998508	piR-32986	piR-hsa-13197	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-32986 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000629	25305452	DQ596311	piR-hsa-26527	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596311 may correlated with the increased risk of Bladder carcinoma.
PIRP00000629	25313140	DQ596311	piR-hsa-26527	Breast carcinoma	EFO:0000305	downregulation	increased risk	breast cancer	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of DQ596311 may correlated with the increased risk of Breast carcinoma.
PIRP00000629	27429044	hsa_piR_019168	piR-hsa-26527	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_019168 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000630	25305452	DQ591143	piR-hsa-20887	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ591143 may correlated with the increased risk of Bladder carcinoma.
PIRP00000631	27197292	piR-18913	piR-hsa-26213	Glioma	EFO:0005543	rs62435800	decreased risk	glioma cell	N/A	N/A	N/A	0.20	The piRNAs dysregulation associated with Glioma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Glioma was validated by RT-PCR. The validated results indicated that the rs62435800 of piR-18913 may correlated with the decreased risk of Glioma. Moreover, the molecular functions or physiological functions of piR-18913 involving in the pathologies of Glioma are illustrated in cell lines in vitro. Altogether, all above results suggested that the rs62435800 of piR-18913 is possibly correlated with the decreased risk of Glioma.
PIRP00000632	27323410	piR-35469	piR-hsa-27140	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-35469 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000632	27429044	hsa_piR_019951	piR-hsa-27140	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_019951 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000633	25305452	DQ596313	piR-hsa-26529	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596313 may correlated with the increased risk of Bladder carcinoma.
PIRP00000634	27323410	piR-61919	piR-hsa-26039	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-61919 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000635	27429044	hsa_piR_010155	piR-hsa-13940	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_010155 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000636	25305452	DQ596282	piR-hsa-26498	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596282 may correlated with the increased risk of Bladder carcinoma.
PIRP00000637	29516567	piR-36095	piR-hsa-28244	Neuroblastoma	EFO:0000621	upregulation	increased risk	neuroblastoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Neuroblastoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36095 may correlated with the increased risk of Neuroblastoma.
PIRP00000638	29382334	piR-1245	piR-hsa-1963	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer patients	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-1245 may correlated with the increased risk of Bladder carcinoma.
PIRP00000638	29382334	piR-1245	piR-hsa-1963	Breast carcinoma	EFO:0000305	upregulation	increased risk	breast cancer patients	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-1245 may correlated with the increased risk of Breast carcinoma.
PIRP00000638	29382334	piR-1245	piR-hsa-1963	Colorectal cancer	EFO:0005842	upregulation	increased risk and poor progonosis	colorectal cancer patients	N/A	ATF3; BTG1; DUSP1; FAS,NFKBIA; UPP1; SESN2; TP53INP1; MDX1	Cell proliferation, cell death and apoptosis	0.40	The piRNAs dysregulation associated with Colorectal cancer was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Colorectal cancer was validated by RT-PCR. The validated results indicated that the upregulation of piR-1245 may correlated with the increased risk and poor progonosis of Colorectal cancer. Moreover, both molecular functions and physiological functions of piR-1245 involving in the pathologies of Colorectal cancer are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-1245 is possibly correlated with the increased risk and poor progonosis of Colorectal cancer.
PIRP00000638	29382334	piR-1245	piR-hsa-1963	Lung carcinoma	EFO:0001071	upregulation	increased risk	lung cancer patients and cell lines	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Lung carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-1245 may correlated with the increased risk of Lung carcinoma.
PIRP00000638	29382334	piR-1245	piR-hsa-1963	Pancreatic carcinoma	EFO:0002618	upregulation	increased risk	prostate cancer patients	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Pancreatic carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-1245 may correlated with the increased risk of Pancreatic carcinoma.
PIRP00000638	29382334	piR-1245	piR-hsa-1963	Renal carcinoma	EFO:0002890	upregulation	increased risk	kidney cancer patients	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Renal carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-1245 may correlated with the increased risk of Renal carcinoma.
PIRP00000639	25305452	DQ585568	piR-hsa-15863	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ585568 may correlated with the increased risk of Bladder carcinoma.
PIRP00000640	28654860	piR-hsa-22564	piR-hsa-22564	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-22564 may correlated with the increased risk of Alzheimer's disease.
PIRP00000641	25305452	DQ583718	piR-hsa-13984	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ583718 may correlated with the increased risk of Bladder carcinoma.
PIRP00000642	25305452	DQ585569	piR-hsa-15864	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ585569 may correlated with the increased risk of Bladder carcinoma.
PIRP00000643	28651359	DQ596470	piR-hsa-26686	Diminished ovarian reserve	EFO:0004770	upregulation	increased risk	patients with diminished ovarian reserve	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Diminished ovarian reserve was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Diminished ovarian reserve was validated by RT-PCR. The validated results indicated that the upregulation of DQ596470 may correlated with the increased risk of Diminished ovarian reserve.
PIRP00000644	26071182	piR-57125	piR-hsa-20266	Clear cell renal cell carcinomas	EFO:0000349	downregulation	poor progonosis	clear cell renal cell carcinomas patients	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Clear cell renal cell carcinomas was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Clear cell renal cell carcinomas was validated by RT-PCR. The validated results indicated that the downregulation of piR-57125 may correlated with the poor progonosis of Clear cell renal cell carcinomas.
PIRP00000644	27323410	piR-57125	piR-hsa-20266	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-57125 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00000644	27429044	hsa_piR_014620	piR-hsa-20266	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_014620 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000644	28460486	piR-57125	piR-hsa-20266	Lung adenocarcinoma	EFO:0000571	downregulation	poor progonosis	lung adenocarcinoma	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Lung adenocarcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung adenocarcinoma was validated by RT-PCR. The validated results indicated that the downregulation of piR-57125 may correlated with the poor progonosis of Lung adenocarcinoma.
PIRP00000645	25305452	DQ575689	piR-hsa-5967	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ575689 may correlated with the increased risk of Bladder carcinoma.
PIRP00000646	28654860	piR-hsa-26293	piR-hsa-26293	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-26293 may correlated with the increased risk of Alzheimer's disease.
PIRP00000647	25305452	DQ584405	piR-hsa-14730	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ584405 may correlated with the increased risk of Bladder carcinoma.
PIRP00000648	25998508	piR-32635	piR-hsa-12746	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-32635 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000649	25305452	DQ578335	piR-hsa-8576	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ578335 may correlated with the increased risk of Bladder carcinoma.
PIRP00000650	25779046	pi-sno75	pi-sno75	Breast carcinoma	EFO:0000305	downregulation	increased risk	breast cancer cells	N/A	TRAIL	hCOMPASS-like complexes	-0.8	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of pi-sno75 may correlated with the increased risk of Breast carcinoma. Moreover, both molecular functions, physiological functions and/or mechanisms of pi-sno75 involving in the pathologies of Breast carcinoma are illustrated in cell lines in vitro. Furthermore, the animal model experiments in vivo (eg. xenograft, transgenic) also demonstrated and supported the pi-sno75 dysregulation associated with the pathologies of Breast carcinoma. Altogether, all above results suggested that the downregulation of pi-sno75 is possibly correlated with the increased risk of Breast carcinoma.
PIRP00000651	25998508	piR-32636	piR-hsa-12747	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-32636 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000652	27429044	hsa_piR_021214	piR-hsa-29114	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_021214 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000653	27323410	piR-33044	piR-hsa-23210	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-33044 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000654	25998508	piR-32637	piR-hsa-12748	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-32637 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000655	25305452	DQ583545	piR-hsa-13825	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ583545 may correlated with the increased risk of Bladder carcinoma.
PIRP00000656	27323410	piR-43771	piR-hsa-5937	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-43771 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000657	25305452	DQ583325	piR-hsa-13634	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ583325 may correlated with the increased risk of Bladder carcinoma.
PIRP00000658	25305452	DQ577459	piR-hsa-7734	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ577459 may correlated with the increased risk of Bladder carcinoma.
PIRP00000659	25998508	piR-43147	piR-hsa-5341	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-43147 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000660	27323410	piR-43772	piR-hsa-5938	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-43772 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000661	25305452	DQ575036	piR-hsa-5342	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ575036 may correlated with the increased risk of Bladder carcinoma.
PIRP00000662	25305452	DQ574995	piR-hsa-5301	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ574995 may correlated with the increased risk of Bladder carcinoma.
PIRP00000663	25305452	DQ570989	piR-hsa-1240	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ570989 may correlated with the increased risk of Bladder carcinoma.
PIRP00000664	25305452	DQ585286	piR-hsa-15597	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ585286 may correlated with the increased risk of Bladder carcinoma.
PIRP00000665	25305452	DQ585287	piR-hsa-15598	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ585287 may correlated with the increased risk of Bladder carcinoma.
PIRP00000666	26265322	piR-004172	piR-hsa-5963	Testicular germ cell tumor	EFO:1000566	downregulation	increased risk	testicular germ cell tumors	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Testicular germ cell tumor was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Testicular germ cell tumor was validated by RT-PCR. The validated results indicated that the downregulation of piR-004172 may correlated with the increased risk of Testicular germ cell tumor.
PIRP00000667	25305452	DQ571055	piR-hsa-1306	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ571055 may correlated with the increased risk of Bladder carcinoma.
PIRP00000668	23229900	piR-4987	piR-hsa-7193	Breast carcinoma	EFO:0000305	upregulation	increased risk and poor progonosis	resected breast cancer cases	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-4987 may correlated with the increased risk and poor progonosis of Breast carcinoma.
PIRP00000668	27429044	hsa_piR_004987	piR-hsa-7193	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_004987 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000669	25305452	DQ600951	piR-hsa-31237	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ600951 may correlated with the increased risk of Bladder carcinoma.
PIRP00000670	25305452	DQ570996	piR-hsa-1247	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ570996 may correlated with the increased risk of Bladder carcinoma.
PIRP00000671	25305452	DQ588925	piR-hsa-19207	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ588925 may correlated with the increased risk of Bladder carcinoma.
PIRP00000672	25305452	DQ600952	piR-hsa-31238	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ600952 may correlated with the increased risk of Bladder carcinoma.
PIRP00000673	28654860	piR-hsa-1280	piR-hsa-1280	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-1280 may correlated with the increased risk of Alzheimer's disease.
PIRP00000674	27429044	hsa_piR_017724	piR-hsa-24684	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_017724 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000675	21616063	piR-651	piR-hsa-1077	Breast carcinoma	EFO:0000305	upregulation	increased risk	breast cancer tissues	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-651 may correlated with the increased risk of Breast carcinoma.
PIRP00000675	21616063	piR-651	piR-hsa-1077	Gastric carcinoma	EFO:0000178	upregulation	increased risk and poor progonosis	gastric cancer and  gastric cancer cell lines	N/A	N/A	Cell proliferation	0.40	The piRNAs dysregulation associated with Gastric carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Gastric carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-651 may correlated with the increased risk and poor progonosis of Gastric carcinoma. Moreover, both molecular functions and physiological functions of piR-651 involving in the pathologies of Gastric carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-651 is possibly correlated with the increased risk and poor progonosis of Gastric carcinoma.
PIRP00000675	21616063	piR-651	piR-hsa-1077	Lung carcinoma	EFO:0001071	upregulation	increased risk	lung cancer tissues	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Lung carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-651 may correlated with the increased risk of Lung carcinoma.
PIRP00000675	26071182	piR-30924	piR-hsa-1077	Clear cell renal cell carcinomas	EFO:0000349	upregulation	poor progonosis	clear cell renal cell carcinomas patients	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Clear cell renal cell carcinomas was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Clear cell renal cell carcinomas was validated by RT-PCR. The validated results indicated that the upregulation of piR-30924 may correlated with the poor progonosis of Clear cell renal cell carcinomas.
PIRP00000675	27414029	piR-651	piR-hsa-1077	Breast carcinoma	EFO:0000305	upregulation	decreased risk	breast cancer cell lines	hormone treatment	N/A	Cell proliferation and EMT signaling pathway	-0.2	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-651 may correlated with the decreased risk of Breast carcinoma. Moreover, the molecular functions or physiological functions of piR-651 involving in the pathologies of Breast carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-651 is possibly correlated with the decreased risk of Breast carcinoma.
PIRP00000675	27414029	piR-651	piR-hsa-1077	Pancreatic carcinoma	EFO:0002618	upregulation	decreased risk	prostate cancer cell lines	hormone treatment	N/A	Cell proliferation and EMT signaling pathway	-0.2	The piRNAs dysregulation associated with Pancreatic carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Pancreatic carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-651 may correlated with the decreased risk of Pancreatic carcinoma. Moreover, the molecular functions or physiological functions of piR-651 involving in the pathologies of Pancreatic carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-651 is possibly correlated with the decreased risk of Pancreatic carcinoma.
PIRP00000676	25313140	DQ598677	piR-hsa-28877	Breast carcinoma	EFO:0000305	upregulation	increased risk	breast cancer	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of DQ598677 may correlated with the increased risk of Breast carcinoma.
PIRP00000677	28654860	piR-hsa-1281	piR-hsa-1281	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-1281 may correlated with the increased risk of Alzheimer's disease.
PIRP00000678	28654860	piR-hsa-8163	piR-hsa-8163	Alzheimer's disease	EFO:0000249	downregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-hsa-8163 may correlated with the increased risk of Alzheimer's disease.
PIRP00000679	27429044	hsa_piR_001205	piR-hsa-1359	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_001205 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000680	28654860	piR-hsa-1282	piR-hsa-1282	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-1282 may correlated with the increased risk of Alzheimer's disease.
PIRP00000681	28654860	piR-hsa-28187	piR-hsa-28187	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-28187 may correlated with the increased risk of Alzheimer's disease.
PIRP00000682	28654860	piR-hsa-28188	piR-hsa-28188	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-28188 may correlated with the increased risk of Alzheimer's disease.
PIRP00000683	27323410	piR-33510	piR-hsa-22905	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-33510 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000684	27197292	piR-598	piR-hsa-1006	Glioma	EFO:0005543	rs147061479	increased risk	glioma cell	N/A	N/A	Cell proliferation	-0.4	The piRNAs dysregulation associated with Glioma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Glioma was validated by RT-PCR. The validated results indicated that the rs147061479 of piR-598 may correlated with the increased risk of Glioma. Moreover, both molecular functions and physiological functions of piR-598 involving in the pathologies of Glioma are illustrated in cell lines in vitro. Altogether, all above results suggested that the rs147061479 of piR-598 is possibly correlated with the increased risk of Glioma.
PIRP00000685	25305452	DQ587911	piR-hsa-18158	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ587911 may correlated with the increased risk of Bladder carcinoma.
PIRP00000686	25305452	DQ591460	piR-hsa-21724	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ591460 may correlated with the increased risk of Bladder carcinoma.
PIRP00000687	28654860	piR-hsa-28189	piR-hsa-28189	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-28189 may correlated with the increased risk of Alzheimer's disease.
PIRP00000688	23229900	piR-20485	piR-hsa-28374	Breast carcinoma	EFO:0000305	upregulation	increased risk	resected breast cancer cases	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-20485 may correlated with the increased risk of Breast carcinoma.
PIRP00000689	25305452	DQ591143	piR-hsa-20887	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ591143 may correlated with the increased risk of Bladder carcinoma.
PIRP00000690	27323410	piR-39307	piR-hsa-31511	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-39307 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000691	27429044	hsa_piR_010894	piR-hsa-15023	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_010894 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000692	27429044	hsa_piR_020362	piR-hsa-28183	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_020362 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000693	23229900	piR-20582	piR-hsa-28527	Breast carcinoma	EFO:0000305	upregulation	increased risk	resected breast cancer cases	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-20582 may correlated with the increased risk of Breast carcinoma.
PIRP00000694	27429044	hsa_piR_020363	piR-hsa-28185	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_020363 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000695	28654860	piR-hsa-10907	piR-hsa-10907	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-10907 may correlated with the increased risk of Alzheimer's disease.
PIRP00000696	27429044	hsa_piR_020364	piR-hsa-28186	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_020364 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000697	25305452	DQ597833	piR-hsa-28063	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ597833 may correlated with the increased risk of Bladder carcinoma.
PIRP00000698	27323410	piR-36038	piR-hsa-28187	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36038 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000699	27323410	piR-36039	piR-hsa-28188	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36039 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000700	27323410	piR-36040	piR-hsa-28189	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36040 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000701	25305452	DQ588688	piR-hsa-18985	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ588688 may correlated with the increased risk of Bladder carcinoma.
PIRP00000702	28654860	piR-hsa-23566	piR-hsa-23566	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-23566 may correlated with the increased risk of Alzheimer's disease.
PIRP00000703	25305452	DQ583718	piR-hsa-13984	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ583718 may correlated with the increased risk of Bladder carcinoma.
PIRP00000704	25779424	FR222326	FR222326	Gastric carcinoma	EFO:0000178	upregulation	poor progonosis	gastric cancer recurrence	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Gastric carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of FR222326 may correlated with the poor progonosis of Gastric carcinoma.
PIRP00000705	25305452	DQ572459	piR-hsa-2695	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ572459 may correlated with the increased risk of Bladder carcinoma.
PIRP00000706	27323410	piR-30229	piR-hsa-426	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-30229 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000706	28109471	piR-30229	piR-hsa-426	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-30229 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00000707	25305452	DQ576078	piR-hsa-6341	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ576078 may correlated with the increased risk of Bladder carcinoma.
PIRP00000708	25305452	DQ588363	piR-hsa-18594	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ588363 may correlated with the increased risk of Bladder carcinoma.
PIRP00000709	27323410	piR-31355	piR-hsa-1580	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-31355 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000710	25305452	DQ583325	piR-hsa-13634	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ583325 may correlated with the increased risk of Bladder carcinoma.
PIRP00000711	27197292	piR-3266	piR-hsa-4668	Glioma	EFO:0005543	rs35712968	decreased risk	glioma cell	N/A	N/A	N/A	0.20	The piRNAs dysregulation associated with Glioma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Glioma was validated by RT-PCR. The validated results indicated that the rs35712968 of piR-3266 may correlated with the decreased risk of Glioma. Moreover, the molecular functions or physiological functions of piR-3266 involving in the pathologies of Glioma are illustrated in cell lines in vitro. Altogether, all above results suggested that the rs35712968 of piR-3266 is possibly correlated with the decreased risk of Glioma.
PIRP00000712	28654860	piR-hsa-23259	piR-hsa-23259	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-23259 may correlated with the increased risk of Alzheimer's disease.
PIRP00000713	25305452	DQ589140	piR-hsa-19422	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ589140 may correlated with the increased risk of Bladder carcinoma.
PIRP00000714	23112866	DQ601291	piR-hsa-31561	Sertoli cell-only syndrome	EFO:1001422	downregulation	increased risk	sertoli cell-only syndrome and spermatogenic failure patients	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Sertoli cell-only syndrome was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Sertoli cell-only syndrome was validated by RT-PCR. The validated results indicated that the downregulation of DQ601291 may correlated with the increased risk of Sertoli cell-only syndrome.
PIRP00000715	28654860	piR-hsa-13701	piR-hsa-13701	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-13701 may correlated with the increased risk of Alzheimer's disease.
PIRP00000716	28826361	piR-39888	piR-hsa-32046	Idiopathic male infertility	EFO:0004248	upregulation	increased risk	sperm concentration and fertilization rate after ICSI	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Idiopathic male infertility was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Idiopathic male infertility was validated by RT-PCR. The validated results indicated that the upregulation of piR-39888 may correlated with the increased risk of Idiopathic male infertility.
PIRP00000717	25305452	DQ584144	piR-hsa-14366	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ584144 may correlated with the increased risk of Bladder carcinoma.
PIRP00000718	28654860	piR-hsa-21497	piR-hsa-21497	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-21497 may correlated with the increased risk of Alzheimer's disease.
PIRP00000719	25305452	DQ575764	piR-hsa-6042	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ575764 may correlated with the increased risk of Bladder carcinoma.
PIRP00000720	25305452	DQ571021	piR-hsa-1272	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ571021 may correlated with the increased risk of Bladder carcinoma.
PIRP00000721	27429044	hsa_piR_013306	piR-hsa-18287	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_013306 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000722	25305452	DQ580006	piR-hsa-10246	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ580006 may correlated with the increased risk of Bladder carcinoma.
PIRP00000722	27429044	hsa_piR_007336	piR-hsa-10246	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_007336 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000723	27197292	piR-2799	piR-hsa-4045	Glioma	EFO:0005543	rs149336947	increased risk	glioma cell	N/A	N/A	N/A	-0.2	The piRNAs dysregulation associated with Glioma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Glioma was validated by RT-PCR. The validated results indicated that the rs149336947 of piR-2799 may correlated with the increased risk of Glioma. Moreover, the molecular functions or physiological functions of piR-2799 involving in the pathologies of Glioma are illustrated in cell lines in vitro. Altogether, all above results suggested that the rs149336947 of piR-2799 is possibly correlated with the increased risk of Glioma.
PIRP00000724	28654860	piR-hsa-1280	piR-hsa-1280	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-1280 may correlated with the increased risk of Alzheimer's disease.
PIRP00000725	28654860	piR-hsa-8163	piR-hsa-8163	Alzheimer's disease	EFO:0000249	downregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-hsa-8163 may correlated with the increased risk of Alzheimer's disease.
PIRP00000726	28654860	piR-hsa-1281	piR-hsa-1281	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-1281 may correlated with the increased risk of Alzheimer's disease.
PIRP00000727	25998508	piR-32105	piR-hsa-12232	Renal cell carcinoma	EFO:0000681	upregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-32105 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000728	25305452	DQ596354	piR-hsa-26570	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596354 may correlated with the increased risk of Bladder carcinoma.
PIRP00000728	27429044	hsa_piR_019201	piR-hsa-26570	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_019201 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000728	27829231	DQ596354	piR-hsa-26570	Lung adenocarcinoma	EFO:0000571	upregulation	poor progonosis	lung adenocarcinoma samples	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Lung adenocarcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung adenocarcinoma was validated by RT-PCR. The validated results indicated that the upregulation of DQ596354 may correlated with the poor progonosis of Lung adenocarcinoma.
PIRP00000728	27829231	DQ596354	piR-hsa-26570	Squamous cell lung carcinoma	EFO:0000708	upregulation	poor progonosis	lung squamous cell carcinoma samples	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Squamous cell lung carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Squamous cell lung carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of DQ596354 may correlated with the poor progonosis of Squamous cell lung carcinoma.
PIRP00000729	27429044	hsa_piR_020009	piR-hsa-27730	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_020009 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000730	28654860	piR-hsa-1282	piR-hsa-1282	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-1282 may correlated with the increased risk of Alzheimer's disease.
PIRP00000731	27323410	piR-33534	piR-hsa-23670	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-33534 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000732	25305452	DQ596314	piR-hsa-26530	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596314 may correlated with the increased risk of Bladder carcinoma.
PIRP00000733	25305452	DQ596356	piR-hsa-26572	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596356 may correlated with the increased risk of Bladder carcinoma.
PIRP00000734	25305452	DQ593739	piR-hsa-23987	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ593739 may correlated with the increased risk of Bladder carcinoma.
PIRP00000735	27323410	piR-41794	piR-hsa-3961	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-41794 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000736	28651359	DQ594461	piR-hsa-24680	Diminished ovarian reserve	EFO:0004770	upregulation	increased risk	patients with diminished ovarian reserve	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Diminished ovarian reserve was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ594461 may correlated with the increased risk of Diminished ovarian reserve.
PIRP00000737	25998508	piR-43147	piR-hsa-5341	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-43147 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000738	28654860	piR-hsa-11988	piR-hsa-11988	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-11988 may correlated with the increased risk of Alzheimer's disease.
PIRP00000739	28654860	piR-hsa-11907	piR-hsa-11907	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-11907 may correlated with the increased risk of Alzheimer's disease.
PIRP00000740	27429044	hsa_piR_016970	piR-hsa-23655	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_016970 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000741	28651359	DQ594465	piR-hsa-24684	Diminished ovarian reserve	EFO:0004770	upregulation	increased risk	patients with diminished ovarian reserve	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Diminished ovarian reserve was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Diminished ovarian reserve was validated by RT-PCR. The validated results indicated that the upregulation of DQ594465 may correlated with the increased risk of Diminished ovarian reserve.
PIRP00000742	25305452	DQ570215	piR-hsa-524	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ570215 may correlated with the increased risk of Bladder carcinoma.
PIRP00000743	25305452	DQ593431	piR-hsa-23679	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ593431 may correlated with the increased risk of Bladder carcinoma.
PIRP00000744	25305452	DQ593354	piR-hsa-23617	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ593354 may correlated with the increased risk of Bladder carcinoma.
PIRP00000745	25305452	DQ585568	piR-hsa-15863	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ585568 may correlated with the increased risk of Bladder carcinoma.
PIRP00000746	25305452	DQ585569	piR-hsa-15864	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ585569 may correlated with the increased risk of Bladder carcinoma.
PIRP00000747	25305452	DQ588688	piR-hsa-18985	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ588688 may correlated with the increased risk of Bladder carcinoma.
PIRP00000748	25305452	DQ590181	piR-hsa-20405	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ590181 may correlated with the increased risk of Bladder carcinoma.
PIRP00000749	25305452	DQ596854	piR-hsa-27056	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ596854 may correlated with the increased risk of Bladder carcinoma.
PIRP00000750	25305452	DQ582571	piR-hsa-12794	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ582571 may correlated with the increased risk of Bladder carcinoma.
PIRP00000751	26071182	piR-38756	piR-hsa-30978	Clear cell renal cell carcinomas	EFO:0000349	upregulation	poor progonosis	clear cell renal cell carcinomas patients	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Clear cell renal cell carcinomas was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Clear cell renal cell carcinomas was validated by RT-PCR. The validated results indicated that the upregulation of piR-38756 may correlated with the poor progonosis of Clear cell renal cell carcinomas.
PIRP00000752	27323410	piR-34456	piR-hsa-26606	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-34456 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000753	26148798	DQ597484	piR-hsa-27730	Asthma	EFO:0000270	upregulation	increased risk	asthmatic patientss	N/A	N/A	Akt signaling pathway	0.10	The piRNAs dysregulation associated with Asthma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Asthma was validated by RT-PCR. The validated results indicated that the upregulation of DQ597484 may correlated with the increased risk of Asthma.
PIRP00000754	27323410	piR-30229	piR-hsa-426	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-30229 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000754	28109471	piR-30229	piR-hsa-426	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-30229 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00000755	29516567	piR-36095	piR-hsa-28244	Neuroblastoma	EFO:0000621	upregulation	increased risk	neuroblastoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Neuroblastoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36095 may correlated with the increased risk of Neuroblastoma.
PIRP00000756	25305452	DQ585286	piR-hsa-15597	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ585286 may correlated with the increased risk of Bladder carcinoma.
PIRP00000757	25998508	piR-54403	piR-hsa-17582	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-54403 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000758	25305452	DQ585287	piR-hsa-15598	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ585287 may correlated with the increased risk of Bladder carcinoma.
PIRP00000759	28654860	piR-hsa-23848	piR-hsa-23848	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-23848 may correlated with the increased risk of Alzheimer's disease.
PIRP00000760	25305452	DQ570657	piR-hsa-922	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ570657 may correlated with the increased risk of Bladder carcinoma.
PIRP00000761	25998508	piR-58594	piR-hsa-21746	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-58594 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000762	25305452	DQ596466	piR-hsa-26682	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ596466 may correlated with the increased risk of Bladder carcinoma.
PIRP00000763	25305452	DQ584144	piR-hsa-14366	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ584144 may correlated with the increased risk of Bladder carcinoma.
PIRP00000764	25998508	piR-58595	piR-hsa-21747	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-58595 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000765	27429044	hsa_piR_009051	piR-hsa-12487	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_009051 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000766	25305452	DQ596468	piR-hsa-26684	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ596468 may correlated with the increased risk of Bladder carcinoma.
PIRP00000767	25305452	DQ600938	piR-hsa-31224	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ600938 may correlated with the increased risk of Bladder carcinoma.
PIRP00000768	25305452	DQ570657	piR-hsa-922	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ570657 may correlated with the increased risk of Bladder carcinoma.
PIRP00000769	25305452	DQ588925	piR-hsa-19207	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ588925 may correlated with the increased risk of Bladder carcinoma.
PIRP00000770	25305452	DQ577000	piR-hsa-7319	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ577000 may correlated with the increased risk of Bladder carcinoma.
PIRP00000771	28654860	piR-hsa-23538	piR-hsa-23538	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-23538 may correlated with the increased risk of Alzheimer's disease.
PIRP00000772	27429044	hsa_piR_019822	piR-hsa-27490	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_019822 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000773	25305452	DQ596354	piR-hsa-26570	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596354 may correlated with the increased risk of Bladder carcinoma.
PIRP00000774	25305452	DQ575973	piR-hsa-6236	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ575973 may correlated with the increased risk of Bladder carcinoma.
PIRP00000775	27323410	piR-34456	piR-hsa-26606	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-34456 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000776	25305452	DQ596314	piR-hsa-26530	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596314 may correlated with the increased risk of Bladder carcinoma.
PIRP00000777	25998508	piR-32051	piR-hsa-12178	Renal cell carcinoma	EFO:0000681	upregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	0.20	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Renal cell carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-32051 may correlated with the increased risk and poor progonosis of Renal cell carcinoma. Moreover, the molecular functions or physiological functions of piR-32051 involving in the pathologies of Renal cell carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-32051 is possibly correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000778	25305452	DQ571998	piR-hsa-2278	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ571998 may correlated with the increased risk of Bladder carcinoma.
PIRP00000779	27429044	hsa_piR_019824	piR-hsa-27492	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_019824 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000780	25305452	DQ596356	piR-hsa-26572	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596356 may correlated with the increased risk of Bladder carcinoma.
PIRP00000781	23229900	piR-19825	piR-hsa-27493	Breast carcinoma	EFO:0000305	upregulation	increased risk	resected breast cancer cases	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-19825 may correlated with the increased risk of Breast carcinoma.
PIRP00000781	27323410	piR-35284	piR-hsa-27493	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-35284 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000782	27893851	DQ592932	piR-hsa-23210	Rheumatoid arthritis	EFO:0000685	upregulation	decreased risk	rheumatoid arthritis patients	N/A	N/A	LPS and TNF¦Á induced inflammatory	-0.2	The piRNAs dysregulation associated with Rheumatoid arthritis was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Rheumatoid arthritis was validated by RT-PCR. The validated results indicated that the upregulation of DQ592932 may correlated with the decreased risk of Rheumatoid arthritis. Moreover, the molecular functions or physiological functions of DQ592932 involving in the pathologies of Rheumatoid arthritis are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of DQ592932 is possibly correlated with the decreased risk of Rheumatoid arthritis.
PIRP00000783	27323410	piR-33856	piR-hsa-23992	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-33856 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000784	25305452	DQ596932	piR-hsa-27222	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ596932 may correlated with the increased risk of Bladder carcinoma.
PIRP00000785	27323410	piR-35469	piR-hsa-27140	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-35469 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000785	27429044	hsa_piR_019951	piR-hsa-27140	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_019951 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000786	27429044	hsa_piR_020365	piR-hsa-28190	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_020365 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000787	25305452	DQ595179	piR-hsa-25440	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ595179 may correlated with the increased risk of Bladder carcinoma.
PIRP00000788	28654860	piR-hsa-16363	piR-hsa-16363	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-16363 may correlated with the increased risk of Alzheimer's disease.
PIRP00000789	25305452	DQ589802	piR-hsa-20070	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ589802 may correlated with the increased risk of Bladder carcinoma.
PIRP00000790	27429044	hsa_piR_010155	piR-hsa-13940	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_010155 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000791	28654860	piR-hsa-226	piR-hsa-226	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-226 may correlated with the increased risk of Alzheimer's disease.
PIRP00000792	25779046	pi-sno75	pi-sno75	Breast carcinoma	EFO:0000305	downregulation	increased risk	breast cancer cells	N/A	TRAIL	hCOMPASS-like complexes	-0.8	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of pi-sno75 may correlated with the increased risk of Breast carcinoma. Moreover, both molecular functions, physiological functions and/or mechanisms of pi-sno75 involving in the pathologies of Breast carcinoma are illustrated in cell lines in vitro. Furthermore, the animal model experiments in vivo (eg. xenograft, transgenic) also demonstrated and supported the pi-sno75 dysregulation associated with the pathologies of Breast carcinoma. Altogether, all above results suggested that the downregulation of pi-sno75 is possibly correlated with the increased risk of Breast carcinoma.
PIRP00000793	25998508	piR-43607	piR-hsa-5773	Renal cell carcinoma	EFO:0000681	upregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	0.20	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Renal cell carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-43607 may correlated with the increased risk and poor progonosis of Renal cell carcinoma. Moreover, the molecular functions or physiological functions of piR-43607 involving in the pathologies of Renal cell carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-43607 is possibly correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000794	25305452	DQ583718	piR-hsa-13984	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ583718 may correlated with the increased risk of Bladder carcinoma.
PIRP00000795	27323410	piR-61298	piR-hsa-25447	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-61298 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000796	27429044	hsa_piR_020305	piR-hsa-28117	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_020305 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000797	28654860	piR-hsa-27491	piR-hsa-27491	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-27491 may correlated with the increased risk of Alzheimer's disease.
PIRP00000798	27323410	piR-31531	piR-hsa-1742	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-31531 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000799	25305452	DQ601506	piR-hsa-31746	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ601506 may correlated with the increased risk of Bladder carcinoma.
PIRP00000800	28654860	piR-hsa-27492	piR-hsa-27492	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-27492 may correlated with the increased risk of Alzheimer's disease.
PIRP00000801	28654860	piR-hsa-27725	piR-hsa-27725	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-27725 may correlated with the increased risk of Alzheimer's disease.
PIRP00000802	25305452	DQ601548	piR-hsa-31788	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ601548 may correlated with the increased risk of Bladder carcinoma.
PIRP00000803	25305452	DQ582571	piR-hsa-12794	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ582571 may correlated with the increased risk of Bladder carcinoma.
PIRP00000804	26148798	DQ595186	piR-hsa-25447	Asthma	EFO:0000270	upregulation	increased risk	asthmatic patientss	N/A	N/A	Akt signaling pathway	0.10	The piRNAs dysregulation associated with Asthma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Asthma was validated by RT-PCR. The validated results indicated that the upregulation of DQ595186 may correlated with the increased risk of Asthma.
PIRP00000805	28654860	piR-hsa-30892	piR-hsa-30892	Alzheimer's disease	EFO:0000249	downregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-hsa-30892 may correlated with the increased risk of Alzheimer's disease.
PIRP00000806	27323410	piR-35855	piR-hsa-28019	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-35855 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000807	25305452	DQ583325	piR-hsa-13634	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ583325 may correlated with the increased risk of Bladder carcinoma.
PIRP00000808	28654860	piR-hsa-24887	piR-hsa-24887	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-24887 may correlated with the increased risk of Alzheimer's disease.
PIRP00000809	25998508	piR-32635	piR-hsa-12746	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-32635 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000810	25305452	DQ577543	piR-hsa-7817	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ577543 may correlated with the increased risk of Bladder carcinoma.
PIRP00000811	25305452	DQ582294	piR-hsa-12517	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ582294 may correlated with the increased risk of Bladder carcinoma.
PIRP00000812	28654860	piR-hsa-27140	piR-hsa-27140	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-27140 may correlated with the increased risk of Alzheimer's disease.
PIRP00000813	25998508	piR-32636	piR-hsa-12747	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-32636 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000814	27414029	piR-823	piR-hsa-1282	Pancreatic carcinoma	EFO:0002618	upregulation	increased risk and poor progonosis	prostate cancer cell lines	N/A	mTOR	Cell proliferation and EMT signaling pathway	0.20	The piRNAs dysregulation associated with Pancreatic carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Pancreatic carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-823 may correlated with the increased risk and poor progonosis of Pancreatic carcinoma. Moreover, the molecular functions or physiological functions of piR-823 involving in the pathologies of Pancreatic carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-823 is possibly correlated with the increased risk and poor progonosis of Pancreatic carcinoma.
PIRP00000815	27197292	piR-11714	piR-hsa-16119	Glioma	EFO:0005543	rs142742690	decreased risk	glioma cell	N/A	N/A	N/A	0.20	The piRNAs dysregulation associated with Glioma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Glioma was validated by RT-PCR. The validated results indicated that the rs142742690 of piR-11714 may correlated with the decreased risk of Glioma. Moreover, the molecular functions or physiological functions of piR-11714 involving in the pathologies of Glioma are illustrated in cell lines in vitro. Altogether, all above results suggested that the rs142742690 of piR-11714 is possibly correlated with the decreased risk of Glioma.
PIRP00000816	27323410	piR-54265	piR-hsa-17444	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-54265 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000816	27429044	hsa_piR_012681	piR-hsa-17444	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_012681 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000816	30555542	piR-54265	piR-hsa-17444	Colorectal adenocarcinoma	EFO:0000365	upregulation	increased risk	colorectal adenocarcinoma	N/A	PIWIL2	STAT3 signaling pathway, cell proliferation, metastasis and chemoresistance	0.80	The piRNAs dysregulation associated with Colorectal adenocarcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Colorectal adenocarcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-54265 may correlated with the increased risk of Colorectal adenocarcinoma. Moreover, both molecular functions, physiological functions and/or mechanisms of piR-54265 involving in the pathologies of Colorectal adenocarcinoma are illustrated in cell lines in vitro. Furthermore, the animal model experiments in vivo (eg. xenograft, transgenic) also demonstrated and supported the piR-54265 dysregulation associated with the pathologies of Colorectal adenocarcinoma. Altogether, all above results suggested that the upregulation of piR-54265 is possibly correlated with the increased risk of Colorectal adenocarcinoma.
PIRP00000817	25305452	DQ601166	piR-hsa-31436	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ601166 may correlated with the increased risk of Bladder carcinoma.
PIRP00000818	25998508	piR-32637	piR-hsa-12748	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-32637 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000819	25998508	piR-4018	piR-hsa-5748	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-4018 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000820	25305452	DQ598641	piR-hsa-28841	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ598641 may correlated with the increased risk of Bladder carcinoma.
PIRP00000821	25305452	DQ570901	piR-hsa-1152	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ570901 may correlated with the increased risk of Bladder carcinoma.
PIRP00000822	25305452	DQ580653	piR-hsa-10879	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ580653 may correlated with the increased risk of Bladder carcinoma.
PIRP00000823	25305452	DQ581967	piR-hsa-12206	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ581967 may correlated with the increased risk of Bladder carcinoma.
PIRP00000824	28654860	piR-hsa-24221	piR-hsa-24221	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-24221 may correlated with the increased risk of Alzheimer's disease.
PIRP00000825	25305452	DQ571140	piR-hsa-1477	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ571140 may correlated with the increased risk of Bladder carcinoma.
PIRP00000826	25305452	DQ587101	piR-hsa-17407	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ587101 may correlated with the increased risk of Bladder carcinoma.
PIRP00000827	27323410	piR-36711	piR-hsa-28845	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-36711 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000828	26148798	DQ596390	piR-hsa-26606	Asthma	EFO:0000270	downregulation	increased risk	asthmatic patientss	N/A	N/A	Akt signaling pathway	-0.1	The piRNAs dysregulation associated with Asthma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Asthma was validated by RT-PCR. The validated results indicated that the downregulation of DQ596390 may correlated with the increased risk of Asthma.
PIRP00000829	27323410	piR-36712	piR-hsa-28846	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-36712 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000830	29382334	piR-1245	piR-hsa-1963	Stomach cancer	EFO:0003897	upregulation	increased risk	stomach cancer patients	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Stomach cancer was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-1245 may correlated with the increased risk of Stomach cancer.
PIRP00000831	27323410	piR-36713	piR-hsa-28847	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36713 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000832	27323410	piR-36714	piR-hsa-28848	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36714 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000833	27323410	piR-36715	piR-hsa-28849	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36715 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000834	25305452	DQ576917	piR-hsa-7238	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ576917 may correlated with the increased risk of Bladder carcinoma.
PIRP00000834	27323410	piR-45029	piR-hsa-7238	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-45029 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000834	27429044	hsa_piR_005018	piR-hsa-7238	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_005018 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000835	27429044	hsa_piR_005019	piR-hsa-7239	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_005019 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000836	23112866	DQ591415	piR-hsa-32	Sertoli cell-only syndrome	EFO:1001422	downregulation	increased risk	sertoli cell-only syndrome and spermatogenic failure patients	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Sertoli cell-only syndrome was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Sertoli cell-only syndrome was validated by RT-PCR. The validated results indicated that the downregulation of DQ591415 may correlated with the increased risk of Sertoli cell-only syndrome.
PIRP00000837	28654860	piR-hsa-10710	piR-hsa-10710	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-10710 may correlated with the increased risk of Alzheimer's disease.
PIRP00000838	23229900	piR-20485	piR-hsa-28374	Breast carcinoma	EFO:0000305	upregulation	increased risk	resected breast cancer cases	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-20485 may correlated with the increased risk of Breast carcinoma.
PIRP00000839	27323410	piR-36074	piR-hsa-28223	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-36074 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000840	27323410	piR-34291	piR-hsa-26441	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-34291 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000840	27429044	hsa_piR_019102	piR-hsa-26441	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_019102 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000840	27829231	DQ596225	piR-hsa-26441	Lung adenocarcinoma	EFO:0000571	upregulation	poor progonosis	lung adenocarcinoma samples	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Lung adenocarcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung adenocarcinoma was validated by RT-PCR. The validated results indicated that the upregulation of DQ596225 may correlated with the poor progonosis of Lung adenocarcinoma.
PIRP00000841	25305452	DQ591351	piR-hsa-21616	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ591351 may correlated with the increased risk of Bladder carcinoma.
PIRP00000842	27429044	hsa_piR_020362	piR-hsa-28183	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_020362 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000843	25305452	DQ596932	piR-hsa-27222	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ596932 may correlated with the increased risk of Bladder carcinoma.
PIRP00000844	27429044	hsa_piR_017295	piR-hsa-24143	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_017295 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000845	27429044	hsa_piR_020363	piR-hsa-28185	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_020363 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000846	27429044	hsa_piR_019368	piR-hsa-26819	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_019368 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000847	27429044	hsa_piR_020364	piR-hsa-28186	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_020364 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000848	25779424	FR381169	FR381169	Gastric carcinoma	EFO:0000178	upregulation	poor progonosis	gastric cancer recurrence	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Gastric carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of FR381169 may correlated with the poor progonosis of Gastric carcinoma.
PIRP00000849	27323410	piR-36038	piR-hsa-28187	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36038 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000850	25305452	DQ589802	piR-hsa-20070	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ589802 may correlated with the increased risk of Bladder carcinoma.
PIRP00000851	27323410	piR-62011	piR-hsa-26131	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-62011 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000852	27323410	piR-36039	piR-hsa-28188	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36039 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000853	25998508	piR-57849	piR-hsa-21033	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-57849 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000854	27323410	piR-36040	piR-hsa-28189	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36040 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000855	25305452	DQ589839	piR-hsa-20107	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ589839 may correlated with the increased risk of Bladder carcinoma.
PIRP00000856	25305452	DQ588688	piR-hsa-18985	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ588688 may correlated with the increased risk of Bladder carcinoma.
PIRP00000857	25305452	DQ601506	piR-hsa-31746	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ601506 may correlated with the increased risk of Bladder carcinoma.
PIRP00000858	28654860	piR-hsa-21530	piR-hsa-21530	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-21530 may correlated with the increased risk of Alzheimer's disease.
PIRP00000859	25305452	DQ601548	piR-hsa-31788	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ601548 may correlated with the increased risk of Bladder carcinoma.
PIRP00000860	25305452	DQ572042	piR-hsa-2322	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ572042 may correlated with the increased risk of Bladder carcinoma.
PIRP00000861	27323410	piR-43771	piR-hsa-5937	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-43771 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000862	25305452	DQ585211	piR-hsa-15522	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ585211 may correlated with the increased risk of Bladder carcinoma.
PIRP00000863	27323410	piR-36041	piR-hsa-28190	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36041 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000864	27323410	piR-43772	piR-hsa-5938	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-43772 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000865	25305452	DQ601166	piR-hsa-31436	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ601166 may correlated with the increased risk of Bladder carcinoma.
PIRP00000866	29516567	piR-32512	piR-hsa-12623	Neuroblastoma	EFO:0000621	upregulation	increased risk	neuroblastoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Neuroblastoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-32512 may correlated with the increased risk of Neuroblastoma.
PIRP00000867	25305452	DQ588949	piR-hsa-19231	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ588949 may correlated with the increased risk of Bladder carcinoma.
PIRP00000868	25305452	DQ598641	piR-hsa-28841	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ598641 may correlated with the increased risk of Bladder carcinoma.
PIRP00000869	25305452	DQ584144	piR-hsa-14366	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ584144 may correlated with the increased risk of Bladder carcinoma.
PIRP00000870	27323410	piR-36318	piR-hsa-28467	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36318 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000871	24732595	piR-823	piR-hsa-1282	Multiple myeloma	EFO:0001378	upregulation	increased risk and poor progonosis	multiple myeloma patients and multiple myeloma cell lines	N/A	DNMT3A and 3B	Cell proliferation, cell apoptosis, cell cycle and angiogenesis	0.80	The piRNAs dysregulation associated with Multiple myeloma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Multiple myeloma was validated by RT-PCR. The validated results indicated that the upregulation of piR-823 may correlated with the increased risk and poor progonosis of Multiple myeloma. Moreover, both molecular functions, physiological functions and/or mechanisms of piR-823 involving in the pathologies of Multiple myeloma are illustrated in cell lines in vitro. Furthermore, the animal model experiments in vivo (eg. xenograft, transgenic) also demonstrated and supported the piR-823 dysregulation associated with the pathologies of Multiple myeloma. Altogether, all above results suggested that the upregulation of piR-823 is possibly correlated with the increased risk and poor progonosis of Multiple myeloma.
PIRP00000872	27829231	DQ596225	piR-hsa-26441	Lung adenocarcinoma	EFO:0000571	upregulation	poor progonosis	lung adenocarcinoma samples	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Lung adenocarcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung adenocarcinoma was validated by RT-PCR. The validated results indicated that the upregulation of DQ596225 may correlated with the poor progonosis of Lung adenocarcinoma.
PIRP00000873	25305452	DQ587101	piR-hsa-17407	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ587101 may correlated with the increased risk of Bladder carcinoma.
PIRP00000874	28109471	NONHSAT067200	NONHSAT067200	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	tobacco	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of NONHSAT067200 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00000875	27323410	piR-30840	piR-hsa-993	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-30840 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000876	25305452	DQ588954	piR-hsa-19236	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ588954 may correlated with the increased risk of Bladder carcinoma.
PIRP00000877	25998508	piR-43607	piR-hsa-5773	Renal cell carcinoma	EFO:0000681	upregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	0.20	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Renal cell carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-43607 may correlated with the increased risk and poor progonosis of Renal cell carcinoma. Moreover, the molecular functions or physiological functions of piR-43607 involving in the pathologies of Renal cell carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-43607 is possibly correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000878	25305452	DQ581827	piR-hsa-12081	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ581827 may correlated with the increased risk of Bladder carcinoma.
PIRP00000879	25305452	DQ580927	piR-hsa-11256	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ580927 may correlated with the increased risk of Bladder carcinoma.
PIRP00000879	27429044	hsa_piR_008033	piR-hsa-11256	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_008033 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000880	25305452	DQ586065	piR-hsa-16315	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ586065 may correlated with the increased risk of Bladder carcinoma.
PIRP00000881	27429044	hsa_piR_004987	piR-hsa-7193	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_004987 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000882	29516567	piR-32287	piR-hsa-12399	Neuroblastoma	EFO:0000621	upregulation	increased risk	neuroblastoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Neuroblastoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-32287 may correlated with the increased risk of Neuroblastoma.
PIRP00000883	25305452	DQ571849	piR-hsa-2129	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ571849 may correlated with the increased risk of Bladder carcinoma.
PIRP00000884	29460056	DQ576513	piR-hsa-6761	Azoospermia	EFO:0000279	downregulation	increased risk	patients with nonobstructive azoospermia (NOA) between successful and unsuccessful sperm retrieval before micro-dissection testicular sperm extraction (micro-TESE)	N/A	N/A	Cell apoptosis, cell proliferation, and cell differentiation	-0.1	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of DQ576513 may correlated with the increased risk of Azoospermia.
PIRP00000885	27429044	hsa_piR_001205	piR-hsa-1359	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_001205 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000886	28826361	piR-39888	piR-hsa-32046	Idiopathic male infertility	EFO:0004248	upregulation	increased risk	sperm concentration and fertilization rate after ICSI	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Idiopathic male infertility was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Idiopathic male infertility was validated by RT-PCR. The validated results indicated that the upregulation of piR-39888 may correlated with the increased risk of Idiopathic male infertility.
PIRP00000887	27429044	hsa_piR_016240	piR-hsa-22382	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_016240 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000888	27323410	piR-49143	piR-hsa-11360	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-49143 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000889	27323410	piR-49144	piR-hsa-11361	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-49144 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000890	25305452	DQ597470	piR-hsa-27716	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ597470 may correlated with the increased risk of Bladder carcinoma.
PIRP00000891	25305452	DQ596111	piR-hsa-26343	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596111 may correlated with the increased risk of Bladder carcinoma.
PIRP00000892	27429044	hsa_piR_021190	piR-hsa-29417	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_021190 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000893	27323410	piR-49145	piR-hsa-11362	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-49145 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00000893	28109471	piR-49145	piR-hsa-11362	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-49145 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00000894	25305452	DQ591351	piR-hsa-21616	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ591351 may correlated with the increased risk of Bladder carcinoma.
PIRP00000895	25779424	FR222326	FR222326	Gastric carcinoma	EFO:0000178	upregulation	poor progonosis	gastric cancer recurrence	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Gastric carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of FR222326 may correlated with the poor progonosis of Gastric carcinoma.
PIRP00000896	25998508	piR-54436	piR-hsa-17615	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-54436 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000897	25779424	FR157678	FR157678	Gastric carcinoma	EFO:0000178	upregulation	poor progonosis	gastric cancer recurrence	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Gastric carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of FR157678 may correlated with the poor progonosis of Gastric carcinoma.
PIRP00000898	28109471	NONHSAT067200	NONHSAT067200	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	tobacco	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of NONHSAT067200 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00000899	25305452	DQ581730	piR-hsa-11984	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ581730 may correlated with the increased risk of Bladder carcinoma.
PIRP00000900	25305452	DQ601697	piR-hsa-31921	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ601697 may correlated with the increased risk of Bladder carcinoma.
PIRP00000901	27893851	DQ592932	piR-hsa-23210	Osteoarthritis 	EFO:0002506	upregulation	decreased risk	osteoarthritis patients	N/A	N/A	LPS and TNF¦Á induced inflammatory	-0.2	The piRNAs dysregulation associated with Osteoarthritis  was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Osteoarthritis  was validated by RT-PCR. The validated results indicated that the upregulation of DQ592932 may correlated with the decreased risk of Osteoarthritis . Moreover, the molecular functions or physiological functions of DQ592932 involving in the pathologies of Osteoarthritis  are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of DQ592932 is possibly correlated with the decreased risk of Osteoarthritis .
PIRP00000901	27893851	DQ592932	piR-hsa-23210	Rheumatoid arthritis	EFO:0000685	upregulation	decreased risk	rheumatoid arthritis patients	N/A	N/A	LPS and TNF¦Á induced inflammatory	-0.2	The piRNAs dysregulation associated with Rheumatoid arthritis was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Rheumatoid arthritis was validated by RT-PCR. The validated results indicated that the upregulation of DQ592932 may correlated with the decreased risk of Rheumatoid arthritis. Moreover, the molecular functions or physiological functions of DQ592932 involving in the pathologies of Rheumatoid arthritis are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of DQ592932 is possibly correlated with the decreased risk of Rheumatoid arthritis.
PIRP00000902	25305452	DQ577459	piR-hsa-7734	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ577459 may correlated with the increased risk of Bladder carcinoma.
PIRP00000903	28654860	piR-hsa-15406	piR-hsa-15406	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-15406 may correlated with the increased risk of Alzheimer's disease.
PIRP00000904	25305452	DQ601450	piR-hsa-31691	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ601450 may correlated with the increased risk of Bladder carcinoma.
PIRP00000905	25305452	DQ600310	piR-hsa-30510	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ600310 may correlated with the increased risk of Bladder carcinoma.
PIRP00000906	27323410	piR-35466	piR-hsa-27137	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-35466 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00000907	25305452	DQ577470	piR-hsa-7745	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ577470 may correlated with the increased risk of Bladder carcinoma.
PIRP00000908	27323410	piR-49143	piR-hsa-11360	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-49143 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000909	25998508	piR-64616	piR-rno-50934	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-64616 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000910	27893851	DQ592932	piR-hsa-23210	Osteoarthritis 	EFO:0002506	upregulation	decreased risk	osteoarthritis patients	N/A	N/A	LPS and TNF¦Á induced inflammatory	-0.2	The piRNAs dysregulation associated with Osteoarthritis  was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Osteoarthritis  was validated by RT-PCR. The validated results indicated that the upregulation of DQ592932 may correlated with the decreased risk of Osteoarthritis . Moreover, the molecular functions or physiological functions of DQ592932 involving in the pathologies of Osteoarthritis  are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of DQ592932 is possibly correlated with the decreased risk of Osteoarthritis .
PIRP00000910	27893851	DQ592932	piR-hsa-23210	Rheumatoid arthritis	EFO:0000685	upregulation	decreased risk	rheumatoid arthritis patients	N/A	N/A	LPS and TNF¦Á induced inflammatory	-0.2	The piRNAs dysregulation associated with Rheumatoid arthritis was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Rheumatoid arthritis was validated by RT-PCR. The validated results indicated that the upregulation of DQ592932 may correlated with the decreased risk of Rheumatoid arthritis. Moreover, the molecular functions or physiological functions of DQ592932 involving in the pathologies of Rheumatoid arthritis are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of DQ592932 is possibly correlated with the decreased risk of Rheumatoid arthritis.
PIRP00000911	28654860	piR-hsa-21497	piR-hsa-21497	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-21497 may correlated with the increased risk of Alzheimer's disease.
PIRP00000912	27323410	piR-35467	piR-hsa-27138	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-35467 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00000913	27323410	piR-61919	piR-hsa-26039	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-61919 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000914	27323410	piR-49144	piR-hsa-11361	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-49144 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000915	25305452	DQ577347	piR-hsa-7637	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ577347 may correlated with the increased risk of Bladder carcinoma.
PIRP00000916	27323410	piR-35468	piR-hsa-27139	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-35468 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00000917	29460056	DQ589403	piR-hsa-19671	Azoospermia	EFO:0000279	downregulation	increased risk	patients with nonobstructive azoospermia (NOA) between successful and unsuccessful sperm retrieval before micro-dissection testicular sperm extraction (micro-TESE)	N/A	N/A	Cell apoptosis, cell proliferation, and cell differentiation	-0.1	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of DQ589403 may correlated with the increased risk of Azoospermia.
PIRP00000918	27323410	piR-49145	piR-hsa-11362	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-49145 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00000918	28109471	piR-49145	piR-hsa-11362	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-49145 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00000919	28654860	piR-hsa-28025	piR-hsa-28025	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-28025 may correlated with the increased risk of Alzheimer's disease.
PIRP00000920	23229900	piR-4987	piR-hsa-7193	Breast carcinoma	EFO:0000305	upregulation	increased risk and poor progonosis	resected breast cancer cases	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-4987 may correlated with the increased risk and poor progonosis of Breast carcinoma.
PIRP00000920	27429044	hsa_piR_004987	piR-hsa-7193	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_004987 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000921	27068805	piR-31925	piR-hsa-2107	Azoospermia	EFO:0000279	downregulation	increased risk	seminal plasma of infertile patients	N/A	N/A	N/A	-0.2	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of piR-31925 may correlated with the increased risk of Azoospermia. Moreover, the molecular functions or physiological functions of piR-31925 involving in the pathologies of Azoospermia are illustrated in cell lines in vitro. Altogether, all above results suggested that the downregulation of piR-31925 is possibly correlated with the increased risk of Azoospermia.
PIRP00000922	25305452	DQ589164	piR-hsa-19446	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ589164 may correlated with the increased risk of Bladder carcinoma.
PIRP00000923	28654860	piR-hsa-11139	piR-hsa-11139	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-11139 may correlated with the increased risk of Alzheimer's disease.
PIRP00000924	27429044	hsa_piR_020814	piR-hsa-28850	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_020814 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000925	25305452	DQ597696	piR-hsa-27926	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ597696 may correlated with the increased risk of Bladder carcinoma.
PIRP00000926	29460056	DQ593632	piR-hsa-23880	Azoospermia	EFO:0000279	downregulation	increased risk	patients with nonobstructive azoospermia (NOA) between successful and unsuccessful sperm retrieval before micro-dissection testicular sperm extraction (micro-TESE)	N/A	N/A	Cell apoptosis, cell proliferation, and cell differentiation	-0.1	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of DQ593632 may correlated with the increased risk of Azoospermia.
PIRP00000927	25305452	DQ599994	piR-hsa-30208	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ599994 may correlated with the increased risk of Bladder carcinoma.
PIRP00000928	25305452	DQ575764	piR-hsa-6042	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ575764 may correlated with the increased risk of Bladder carcinoma.
PIRP00000929	25305452	DQ580927	piR-hsa-11256	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ580927 may correlated with the increased risk of Bladder carcinoma.
PIRP00000930	22047710	piR-823	piR-hsa-1282	Gastric carcinoma	EFO:0000178	downregulation	increased risk	gastric cancer cells	N/A	N/A	Cell proliferation	-0.8	The piRNAs dysregulation associated with Gastric carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Gastric carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of piR-823 may correlated with the increased risk of Gastric carcinoma. Moreover, both molecular functions, physiological functions and/or mechanisms of piR-823 involving in the pathologies of Gastric carcinoma are illustrated in cell lines in vitro. Furthermore, the animal model experiments in vivo (eg. xenograft, transgenic) also demonstrated and supported the piR-823 dysregulation associated with the pathologies of Gastric carcinoma. Altogether, all above results suggested that the downregulation of piR-823 is possibly correlated with the increased risk of Gastric carcinoma.
PIRP00000931	26265322	piR-007509	piR-hsa-10476	Seminoma	EFO:0003101	downregulation	increased risk	seminoma	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Seminoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Seminoma was validated by RT-PCR. The validated results indicated that the downregulation of piR-007509 may correlated with the increased risk of Seminoma.
PIRP00000931	26265322	piR-007509	piR-hsa-10476	Testicular germ cell tumor	EFO:1000566	downregulation	increased risk	testicular germ cell tumors	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Testicular germ cell tumor was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Testicular germ cell tumor was validated by RT-PCR. The validated results indicated that the downregulation of piR-007509 may correlated with the increased risk of Testicular germ cell tumor.
PIRP00000932	25305452	DQ600790	piR-hsa-31076	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ600790 may correlated with the increased risk of Bladder carcinoma.
PIRP00000933	23229900	piR-19825	piR-hsa-27493	Breast carcinoma	EFO:0000305	upregulation	increased risk	resected breast cancer cases	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-19825 may correlated with the increased risk of Breast carcinoma.
PIRP00000934	28654860	piR-hsa-4445	piR-hsa-4445	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-4445 may correlated with the increased risk of Alzheimer's disease.
PIRP00000935	27068805	piR-30198	piR-hsa-395	Azoospermia	EFO:0000279	downregulation	increased risk	seminal plasma of infertile patients	N/A	N/A	N/A	-0.2	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of piR-30198 may correlated with the increased risk of Azoospermia. Moreover, the molecular functions or physiological functions of piR-30198 involving in the pathologies of Azoospermia are illustrated in cell lines in vitro. Altogether, all above results suggested that the downregulation of piR-30198 is possibly correlated with the increased risk of Azoospermia.
PIRP00000936	25313140	DQ597341	piR-hsa-27616	Breast carcinoma	EFO:0000305	downregulation	increased risk	breast cancer	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of DQ597341 may correlated with the increased risk of Breast carcinoma.
PIRP00000937	25305452	DQ594556	piR-hsa-24775	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ594556 may correlated with the increased risk of Bladder carcinoma.
PIRP00000937	27429044	hsa_piR_017791	piR-hsa-24775	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_017791 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000938	25305452	DQ596282	piR-hsa-26498	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596282 may correlated with the increased risk of Bladder carcinoma.
PIRP00000939	25305452	DQ579883	piR-hsa-10123	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ579883 may correlated with the increased risk of Bladder carcinoma.
PIRP00000940	25305452	DQ596932	piR-hsa-27222	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ596932 may correlated with the increased risk of Bladder carcinoma.
PIRP00000941	25305452	DQ596111	piR-hsa-26343	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596111 may correlated with the increased risk of Bladder carcinoma.
PIRP00000942	27323410	piR-36338	piR-hsa-28487	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36338 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000943	27323410	piR-30229	piR-hsa-426	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-30229 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000943	28109471	piR-30229	piR-hsa-426	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-30229 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00000944	27323410	piR-36340	piR-hsa-28489	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36340 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000945	25313140	DQ597960	piR-hsa-28175	Breast carcinoma	EFO:0000305	upregulation	increased risk	breast cancer	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of DQ597960 may correlated with the increased risk of Breast carcinoma.
PIRP00000945	27289065	piR-36026	piR-hsa-28175	Breast carcinoma	EFO:0000305	upregulation	increased risk and poor progonosis	MCF-7 breast cancer cell line	N/A	SERPINA1; LRAT; Caspase-3	Cell appoptosis	0.80	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-36026 may correlated with the increased risk and poor progonosis of Breast carcinoma. Moreover, both molecular functions, physiological functions and/or mechanisms of piR-36026 involving in the pathologies of Breast carcinoma are illustrated in cell lines in vitro. Furthermore, the animal model experiments in vivo (eg. xenograft, transgenic) also demonstrated and supported the piR-36026 dysregulation associated with the pathologies of Breast carcinoma. Altogether, all above results suggested that the upregulation of piR-36026 is possibly correlated with the increased risk and poor progonosis of Breast carcinoma.
PIRP00000946	27429044	hsa_piR_018165	piR-hsa-25313	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_018165 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000947	27323410	piR-31355	piR-hsa-1580	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-31355 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000948	26095918	piR-L-163	piR-L-163	Non-small cell lung carcinoma	EFO:0003060	downregulation	increased risk and poor progonosis	non-small cell lung cancer (NSCLC) cell lines	N/A	p-ERM	Cell cycle  and cell migration and cell invasion	-0.6	The piRNAs dysregulation associated with Non-small cell lung carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Non-small cell lung carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of piR-L-163 may correlated with the increased risk and poor progonosis of Non-small cell lung carcinoma. Moreover, both molecular functions, physiological functions and mechanisms of piR-L-163 involving in the pathologies of Non-small cell lung carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the downregulation of piR-L-163 is possibly correlated with the increased risk and poor progonosis of Non-small cell lung carcinoma.
PIRP00000949	27323410	piR-35284	piR-hsa-27493	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-35284 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000950	25779424	FR290353	FR290353	Gastric carcinoma	EFO:0000178	upregulation	poor progonosis	gastric cancer recurrence	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Gastric carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of FR290353 may correlated with the poor progonosis of Gastric carcinoma.
PIRP00000951	27323410	piR-39307	piR-hsa-31511	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-39307 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000952	25779424	FR290353	FR290353	Gastric carcinoma	EFO:0000178	upregulation	poor progonosis	gastric cancer recurrence	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Gastric carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of FR290353 may correlated with the poor progonosis of Gastric carcinoma.
PIRP00000953	27429044	hsa_piR_001152	piR-hsa-1823	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_001152 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000954	25305452	DQ600310	piR-hsa-30510	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ600310 may correlated with the increased risk of Bladder carcinoma.
PIRP00000955	25305452	DQ601506	piR-hsa-31746	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ601506 may correlated with the increased risk of Bladder carcinoma.
PIRP00000956	27323410	piR-35469	piR-hsa-27140	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-35469 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000957	25305452	DQ590938	piR-hsa-21217	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ590938 may correlated with the increased risk of Bladder carcinoma.
PIRP00000958	25305452	DQ601548	piR-hsa-31788	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ601548 may correlated with the increased risk of Bladder carcinoma.
PIRP00000959	25305452	DQ571021	piR-hsa-1272	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ571021 may correlated with the increased risk of Bladder carcinoma.
PIRP00000960	25305452	DQ586986	piR-hsa-17292	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ586986 may correlated with the increased risk of Bladder carcinoma.
PIRP00000961	25305452	DQ589164	piR-hsa-19446	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ589164 may correlated with the increased risk of Bladder carcinoma.
PIRP00000962	25305452	DQ570989	piR-hsa-1240	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ570989 may correlated with the increased risk of Bladder carcinoma.
PIRP00000963	25305452	DQ601166	piR-hsa-31436	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ601166 may correlated with the increased risk of Bladder carcinoma.
PIRP00000964	28826361	piR-31704	piR-hsa-1362	Low 2PN rates among the ICSI operators	UBERON:0000922	upregulation	decreased risk	sperm concentration and fertilization rate after ICSI	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Low 2PN rates among the ICSI operators was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Low 2PN rates among the ICSI operators was validated by RT-PCR. The validated results indicated that the upregulation of piR-31704 may correlated with the decreased risk of Low 2PN rates among the ICSI operators.
PIRP00000965	22047710	piR-823	piR-hsa-1282	Gastric carcinoma	EFO:0000178	downregulation	increased risk	gastric cancer cells	N/A	N/A	Cell proliferation	-0.8	The piRNAs dysregulation associated with Gastric carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Gastric carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of piR-823 may correlated with the increased risk of Gastric carcinoma. Moreover, both molecular functions, physiological functions and/or mechanisms of piR-823 involving in the pathologies of Gastric carcinoma are illustrated in cell lines in vitro. Furthermore, the animal model experiments in vivo (eg. xenograft, transgenic) also demonstrated and supported the piR-823 dysregulation associated with the pathologies of Gastric carcinoma. Altogether, all above results suggested that the downregulation of piR-823 is possibly correlated with the increased risk of Gastric carcinoma.
PIRP00000965	24732595	piR-823	piR-hsa-1282	Multiple myeloma	EFO:0001378	upregulation	increased risk and poor progonosis	multiple myeloma patients and multiple myeloma cell lines	N/A	DNMT3A and 3B	Cell proliferation, cell apoptosis, cell cycle and angiogenesis	0.80	The piRNAs dysregulation associated with Multiple myeloma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Multiple myeloma was validated by RT-PCR. The validated results indicated that the upregulation of piR-823 may correlated with the increased risk and poor progonosis of Multiple myeloma. Moreover, both molecular functions, physiological functions and/or mechanisms of piR-823 involving in the pathologies of Multiple myeloma are illustrated in cell lines in vitro. Furthermore, the animal model experiments in vivo (eg. xenograft, transgenic) also demonstrated and supported the piR-823 dysregulation associated with the pathologies of Multiple myeloma. Altogether, all above results suggested that the upregulation of piR-823 is possibly correlated with the increased risk and poor progonosis of Multiple myeloma.
PIRP00000965	27414029	piR-823	piR-hsa-1282	Breast carcinoma	EFO:0000305	upregulation	poor progonosis	breast cancer cell line which was malignant	N/A	N/A	Cell proliferation and EMT signaling pathway	0.20	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-823 may correlated with the poor progonosis of Breast carcinoma. Moreover, the molecular functions or physiological functions of piR-823 involving in the pathologies of Breast carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-823 is possibly correlated with the poor progonosis of Breast carcinoma.
PIRP00000965	27414029	piR-823	piR-hsa-1282	Pancreatic carcinoma	EFO:0002618	upregulation	increased risk and poor progonosis	prostate cancer cell lines	N/A	mTOR	Cell proliferation and EMT signaling pathway	0.20	The piRNAs dysregulation associated with Pancreatic carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Pancreatic carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-823 may correlated with the increased risk and poor progonosis of Pancreatic carcinoma. Moreover, the molecular functions or physiological functions of piR-823 involving in the pathologies of Pancreatic carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-823 is possibly correlated with the increased risk and poor progonosis of Pancreatic carcinoma.
PIRP00000965	27429044	hsa_piR_000823	piR-hsa-1282	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_000823 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000965	27919963	piR-823	piR-hsa-1282	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	patientss with Renal Cell Carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-823 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000965	28618124	piR-823	piR-hsa-1282	Colorectal cancer	EFO:0005842	upregulation	increased risk	colorectal cancer patients and colorectal cancer cell lines	N/A	HSF1	Cell proliferation, cell death and apoptosis	0.60	The piRNAs dysregulation associated with Colorectal cancer was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Colorectal cancer was validated by RT-PCR. The validated results indicated that the upregulation of piR-823 may correlated with the increased risk of Colorectal cancer. Moreover, both molecular functions, physiological functions and mechanisms of piR-823 involving in the pathologies of Colorectal cancer are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-823 is possibly correlated with the increased risk of Colorectal cancer.
PIRP00000966	25305452	DQ598641	piR-hsa-28841	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ598641 may correlated with the increased risk of Bladder carcinoma.
PIRP00000967	25305452	DQ598409	piR-hsa-28610	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ598409 may correlated with the increased risk of Bladder carcinoma.
PIRP00000968	28651359	DQ581032	piR-hsa-11361	Diminished ovarian reserve	EFO:0004770	upregulation	increased risk	patients with diminished ovarian reserve	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Diminished ovarian reserve was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ581032 may correlated with the increased risk of Diminished ovarian reserve.
PIRP00000969	27829231	DQ596354	piR-hsa-26570	Squamous cell lung carcinoma	EFO:0000708	upregulation	poor progonosis	lung squamous cell carcinoma samples	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Squamous cell lung carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Squamous cell lung carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of DQ596354 may correlated with the poor progonosis of Squamous cell lung carcinoma.
PIRP00000970	27323410	piR-57125	piR-hsa-20266	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-57125 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00000971	25313140	DQ570994	piR-hsa-1245	Breast carcinoma	EFO:0000305	upregulation	increased risk	breast cancer	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of DQ570994 may correlated with the increased risk of Breast carcinoma.
PIRP00000972	23992744	piR-932	piR-hsa-1519	Breast carcinoma	EFO:0000305	upregulation	poor progonosis	breast cancer cell lines	N/A	N/A	EMT signaling pathway	0.20	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-932 may correlated with the poor progonosis of Breast carcinoma. Moreover, the molecular functions or physiological functions of piR-932 involving in the pathologies of Breast carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-932 is possibly correlated with the poor progonosis of Breast carcinoma.
PIRP00000973	25998508	piR-39894	piR-hsa-32052	Renal cell carcinoma	EFO:0000681	upregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	0.20	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Renal cell carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-39894 may correlated with the increased risk and poor progonosis of Renal cell carcinoma. Moreover, the molecular functions or physiological functions of piR-39894 involving in the pathologies of Renal cell carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-39894 is possibly correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00000974	27323410	piR-36711	piR-hsa-28845	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-36711 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000975	27323410	piR-36712	piR-hsa-28846	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-36712 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000976	25305452	DQ591143	piR-hsa-20887	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ591143 may correlated with the increased risk of Bladder carcinoma.
PIRP00000977	25305452	DQ597696	piR-hsa-27926	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ597696 may correlated with the increased risk of Bladder carcinoma.
PIRP00000978	25313140	DQ596670	piR-hsa-26872	Breast carcinoma	EFO:0000305	downregulation	increased risk	breast cancer	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of DQ596670 may correlated with the increased risk of Breast carcinoma.
PIRP00000978	27323410	piR-34736	piR-hsa-26872	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	EMT signaling pathway and cell apoptosis 	0.20	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Head and neck squamous cell carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-34736 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma. Moreover, the molecular functions or physiological functions of piR-34736 involving in the pathologies of Head and neck squamous cell carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-34736 is possibly correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00000978	27429044	hsa_piR_019420	piR-hsa-26872	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_019420 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000979	25305452	DQ570996	piR-hsa-1247	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ570996 may correlated with the increased risk of Bladder carcinoma.
PIRP00000980	27323410	piR-36713	piR-hsa-28847	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36713 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000981	25305452	DQ599994	piR-hsa-30208	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ599994 may correlated with the increased risk of Bladder carcinoma.
PIRP00000982	25305452	DQ599457	piR-hsa-29714	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ599457 may correlated with the increased risk of Bladder carcinoma.
PIRP00000982	27323410	piR-37523	piR-hsa-29714	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-37523 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000983	25305452	DQ577000	piR-hsa-7319	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ577000 may correlated with the increased risk of Bladder carcinoma.
PIRP00000984	27323410	piR-36714	piR-hsa-28848	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36714 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000985	28654860	piR-hsa-8094	piR-hsa-8094	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-8094 may correlated with the increased risk of Alzheimer's disease.
PIRP00000986	25305452	DQ599458	piR-hsa-29715	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ599458 may correlated with the increased risk of Bladder carcinoma.
PIRP00000986	27323410	piR-37524	piR-hsa-29715	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-37524 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000987	27323410	piR-36715	piR-hsa-28849	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36715 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000988	29516567	piR-32512	piR-hsa-12623	Neuroblastoma	EFO:0000621	upregulation	increased risk	neuroblastoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Neuroblastoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-32512 may correlated with the increased risk of Neuroblastoma.
PIRP00000989	25305452	DQ599459	piR-hsa-29716	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ599459 may correlated with the increased risk of Bladder carcinoma.
PIRP00000989	27323410	piR-37525	piR-hsa-29716	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-37525 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000990	29460056	DQ589403	piR-hsa-19671	Azoospermia	EFO:0000279	downregulation	increased risk	patients with nonobstructive azoospermia (NOA) between successful and unsuccessful sperm retrieval before micro-dissection testicular sperm extraction (micro-TESE)	N/A	N/A	Cell apoptosis, cell proliferation, and cell differentiation	-0.1	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of DQ589403 may correlated with the increased risk of Azoospermia.
PIRP00000991	28654860	piR-hsa-15247	piR-hsa-15247	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-15247 may correlated with the increased risk of Alzheimer's disease.
PIRP00000992	25305452	DQ593354	piR-hsa-23617	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ593354 may correlated with the increased risk of Bladder carcinoma.
PIRP00000993	27829231	DQ596306	piR-hsa-26522	Lung adenocarcinoma	EFO:0000571	upregulation	poor progonosis	lung adenocarcinoma samples	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Lung adenocarcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung adenocarcinoma was validated by RT-PCR. The validated results indicated that the upregulation of DQ596306 may correlated with the poor progonosis of Lung adenocarcinoma.
PIRP00000994	27323410	piR-36074	piR-hsa-28223	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-36074 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00000995	25305452	DQ596307	piR-hsa-26523	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596307 may correlated with the increased risk of Bladder carcinoma.
PIRP00000996	25305452	DQ591351	piR-hsa-21616	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ591351 may correlated with the increased risk of Bladder carcinoma.
PIRP00000997	28654860	piR-hsa-27491	piR-hsa-27491	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-27491 may correlated with the increased risk of Alzheimer's disease.
PIRP00000998	25305452	DQ596308	piR-hsa-26524	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596308 may correlated with the increased risk of Bladder carcinoma.
PIRP00000999	26071182	piR-57125	piR-hsa-20266	Clear cell renal cell carcinomas	EFO:0000349	downregulation	poor progonosis	clear cell renal cell carcinomas patients	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Clear cell renal cell carcinomas was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Clear cell renal cell carcinomas was validated by RT-PCR. The validated results indicated that the downregulation of piR-57125 may correlated with the poor progonosis of Clear cell renal cell carcinomas.
PIRP00000999	27323410	piR-57125	piR-hsa-20266	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-57125 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00000999	27429044	hsa_piR_014620	piR-hsa-20266	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_014620 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00000999	28460486	piR-57125	piR-hsa-20266	Lung adenocarcinoma	EFO:0000571	downregulation	poor progonosis	lung adenocarcinoma	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Lung adenocarcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung adenocarcinoma was validated by RT-PCR. The validated results indicated that the downregulation of piR-57125 may correlated with the poor progonosis of Lung adenocarcinoma.
PIRP00001000	28654860	piR-hsa-27725	piR-hsa-27725	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-27725 may correlated with the increased risk of Alzheimer's disease.
PIRP00001001	28654860	piR-hsa-27492	piR-hsa-27492	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-27492 may correlated with the increased risk of Alzheimer's disease.
PIRP00001002	25305452	DQ599177	piR-hsa-29448	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ599177 may correlated with the increased risk of Bladder carcinoma.
PIRP00001003	25305452	DQ596309	piR-hsa-26525	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596309 may correlated with the increased risk of Bladder carcinoma.
PIRP00001003	27829231	DQ596309	piR-hsa-26525	Lung adenocarcinoma	EFO:0000571	upregulation	poor progonosis	lung adenocarcinoma samples	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Lung adenocarcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung adenocarcinoma was validated by RT-PCR. The validated results indicated that the upregulation of DQ596309 may correlated with the poor progonosis of Lung adenocarcinoma.
PIRP00001004	25305452	DQ575340	piR-hsa-5632	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ575340 may correlated with the increased risk of Bladder carcinoma.
PIRP00001005	25305452	DQ596310	piR-hsa-26526	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596310 may correlated with the increased risk of Bladder carcinoma.
PIRP00001006	27323410	piR-36716	piR-hsa-28850	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36716 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001007	25305452	DQ596311	piR-hsa-26527	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596311 may correlated with the increased risk of Bladder carcinoma.
PIRP00001007	25313140	DQ596311	piR-hsa-26527	Breast carcinoma	EFO:0000305	downregulation	increased risk	breast cancer	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of DQ596311 may correlated with the increased risk of Breast carcinoma.
PIRP00001007	27429044	hsa_piR_019168	piR-hsa-26527	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_019168 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001008	27323410	piR-30456	piR-hsa-624	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-30456 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001008	27429044	hsa_piR_000291	piR-hsa-624	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_000291 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001009	29516567	piR-32287	piR-hsa-12399	Neuroblastoma	EFO:0000621	upregulation	increased risk	neuroblastoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Neuroblastoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-32287 may correlated with the increased risk of Neuroblastoma.
PIRP00001010	27197292	piR-18913	piR-hsa-26213	Glioma	EFO:0005543	rs62435800	decreased risk	glioma cell	N/A	N/A	N/A	0.20	The piRNAs dysregulation associated with Glioma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Glioma was validated by RT-PCR. The validated results indicated that the rs62435800 of piR-18913 may correlated with the decreased risk of Glioma. Moreover, the molecular functions or physiological functions of piR-18913 involving in the pathologies of Glioma are illustrated in cell lines in vitro. Altogether, all above results suggested that the rs62435800 of piR-18913 is possibly correlated with the decreased risk of Glioma.
PIRP00001011	27429044	hsa_piR_021214	piR-hsa-29114	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_021214 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001012	28654860	piR-hsa-13408	piR-hsa-13408	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-13408 may correlated with the increased risk of Alzheimer's disease.
PIRP00001013	25305452	DQ579049	piR-hsa-9361	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ579049 may correlated with the increased risk of Bladder carcinoma.
PIRP00001014	28654860	piR-hsa-27140	piR-hsa-27140	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-27140 may correlated with the increased risk of Alzheimer's disease.
PIRP00001015	25305452	DQ596313	piR-hsa-26529	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596313 may correlated with the increased risk of Bladder carcinoma.
PIRP00001016	25305452	DQ592048	piR-hsa-22296	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ592048 may correlated with the increased risk of Bladder carcinoma.
PIRP00001017	29460056	DQ593632	piR-hsa-23880	Azoospermia	EFO:0000279	downregulation	increased risk	patients with nonobstructive azoospermia (NOA) between successful and unsuccessful sperm retrieval before micro-dissection testicular sperm extraction (micro-TESE)	N/A	N/A	Cell apoptosis, cell proliferation, and cell differentiation	-0.1	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of DQ593632 may correlated with the increased risk of Azoospermia.
PIRP00001018	26095918	piR-L-163	piR-L-163	Non-small cell lung carcinoma	EFO:0003060	downregulation	increased risk and poor progonosis	non-small cell lung cancer (NSCLC) cell lines	N/A	p-ERM	Cell cycle  and cell migration and cell invasion	-0.6	The piRNAs dysregulation associated with Non-small cell lung carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Non-small cell lung carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of piR-L-163 may correlated with the increased risk and poor progonosis of Non-small cell lung carcinoma. Moreover, both molecular functions, physiological functions and mechanisms of piR-L-163 involving in the pathologies of Non-small cell lung carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the downregulation of piR-L-163 is possibly correlated with the increased risk and poor progonosis of Non-small cell lung carcinoma.
PIRP00001019	25305452	DQ588525	piR-hsa-18837	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ588525 may correlated with the increased risk of Bladder carcinoma.
PIRP00001020	25305452	DQ581701	piR-hsa-11955	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ581701 may correlated with the increased risk of Bladder carcinoma.
PIRP00001021	28654860	piR-hsa-25652	piR-hsa-25652	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-25652 may correlated with the increased risk of Alzheimer's disease.
PIRP00001022	27414029	piR-823	piR-hsa-1282	Breast carcinoma	EFO:0000305	upregulation	poor progonosis	breast cancer cell line which was malignant	N/A	N/A	Cell proliferation and EMT signaling pathway	0.20	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-823 may correlated with the poor progonosis of Breast carcinoma. Moreover, the molecular functions or physiological functions of piR-823 involving in the pathologies of Breast carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-823 is possibly correlated with the poor progonosis of Breast carcinoma.
PIRP00001023	27323410	piR-31531	piR-hsa-1742	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-31531 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001024	25313140	DQ570994	piR-hsa-1245	Breast carcinoma	EFO:0000305	upregulation	increased risk	breast cancer	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of DQ570994 may correlated with the increased risk of Breast carcinoma.
PIRP00001025	23992744	piR-932	piR-hsa-1519	Breast carcinoma	EFO:0000305	upregulation	poor progonosis	breast cancer cell lines	N/A	N/A	EMT signaling pathway	0.20	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-932 may correlated with the poor progonosis of Breast carcinoma. Moreover, the molecular functions or physiological functions of piR-932 involving in the pathologies of Breast carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-932 is possibly correlated with the poor progonosis of Breast carcinoma.
PIRP00001026	27323410	piR-36082	piR-hsa-28231	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36082 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001027	25305452	DQ586986	piR-hsa-17292	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ586986 may correlated with the increased risk of Bladder carcinoma.
PIRP00001028	27323410	piR-36038	piR-hsa-28187	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36038 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001029	28654860	piR-hsa-25384	piR-hsa-25384	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-25384 may correlated with the increased risk of Alzheimer's disease.
PIRP00001030	27323410	piR-36039	piR-hsa-28188	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36039 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001031	25998508	piR-32635	piR-hsa-12746	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-32635 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001032	25305452	DQ585043	piR-hsa-15354	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ585043 may correlated with the increased risk of Bladder carcinoma.
PIRP00001033	25305452	DQ575973	piR-hsa-6236	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ575973 may correlated with the increased risk of Bladder carcinoma.
PIRP00001034	27323410	piR-36040	piR-hsa-28189	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36040 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001035	25998508	piR-32636	piR-hsa-12747	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-32636 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001036	27829231	DQ596306	piR-hsa-26522	Lung adenocarcinoma	EFO:0000571	upregulation	poor progonosis	lung adenocarcinoma samples	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Lung adenocarcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung adenocarcinoma was validated by RT-PCR. The validated results indicated that the upregulation of DQ596306 may correlated with the poor progonosis of Lung adenocarcinoma.
PIRP00001037	25998508	piR-4018	piR-hsa-5748	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-4018 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001038	25305452	DQ571998	piR-hsa-2278	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ571998 may correlated with the increased risk of Bladder carcinoma.
PIRP00001039	25998508	piR-32637	piR-hsa-12748	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-32637 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001040	25305452	DQ598409	piR-hsa-28610	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ598409 may correlated with the increased risk of Bladder carcinoma.
PIRP00001041	28423657	piR-52200	piR-hsa-15399	Breast carcinoma	EFO:0000305	upregulation	increased risk	breast cancer cell lines	N/A	N/A	AMPK signaling pathway	0.05	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-52200 may correlated with the increased risk of Breast carcinoma.
PIRP00001041	28423657	piR-52200	piR-hsa-15399	Lung carcinoma	EFO:0001071	upregulation	increased risk	lung cancer patients and lung cancer cell lines	N/A	AMPK	AMPK signaling pathway	0.40	The piRNAs dysregulation associated with Lung carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-52200 may correlated with the increased risk of Lung carcinoma. Moreover, both molecular functions and physiological functions of piR-52200 involving in the pathologies of Lung carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-52200 is possibly correlated with the increased risk of Lung carcinoma.
PIRP00001042	27829231	DQ596309	piR-hsa-26525	Lung adenocarcinoma	EFO:0000571	upregulation	poor progonosis	lung adenocarcinoma samples	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Lung adenocarcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung adenocarcinoma was validated by RT-PCR. The validated results indicated that the upregulation of DQ596309 may correlated with the poor progonosis of Lung adenocarcinoma.
PIRP00001043	25305452	DQ571140	piR-hsa-1477	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ571140 may correlated with the increased risk of Bladder carcinoma.
PIRP00001044	28654860	piR-hsa-25074	piR-hsa-25074	Alzheimer's disease	EFO:0000249	downregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-hsa-25074 may correlated with the increased risk of Alzheimer's disease.
PIRP00001045	28654860	piR-hsa-8094	piR-hsa-8094	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-8094 may correlated with the increased risk of Alzheimer's disease.
PIRP00001046	27429044	hsa_piR_010894	piR-hsa-15023	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_010894 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001047	27197292	piR-18913	piR-hsa-26213	Glioma	EFO:0005543	rs62435800	decreased risk	glioma cell	N/A	N/A	N/A	0.20	The piRNAs dysregulation associated with Glioma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Glioma was validated by RT-PCR. The validated results indicated that the rs62435800 of piR-18913 may correlated with the decreased risk of Glioma. Moreover, the molecular functions or physiological functions of piR-18913 involving in the pathologies of Glioma are illustrated in cell lines in vitro. Altogether, all above results suggested that the rs62435800 of piR-18913 is possibly correlated with the decreased risk of Glioma.
PIRP00001048	27429044	hsa_piR_016946	piR-hsa-23621	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_016946 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001049	27429044	hsa_piR_019914	piR-hsa-27622	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_019914 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001050	27429044	hsa_piR_016975	piR-hsa-23663	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_016975 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001051	25305452	DQ570485	piR-hsa-765	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ570485 may correlated with the increased risk of Bladder carcinoma.
PIRP00001052	27429044	hsa_piR_016240	piR-hsa-22382	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_016240 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001053	27429044	hsa_piR_005018	piR-hsa-7238	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_005018 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001054	27429044	hsa_piR_017724	piR-hsa-24684	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_017724 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001055	27323410	piR-33044	piR-hsa-23210	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-33044 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001056	27429044	hsa_piR_005019	piR-hsa-7239	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_005019 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001057	25305452	DQ570324	piR-hsa-180	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ570324 may correlated with the increased risk of Bladder carcinoma.
PIRP00001058	29460056	DQ576513	piR-hsa-6761	Azoospermia	EFO:0000279	downregulation	increased risk	patients with nonobstructive azoospermia (NOA) between successful and unsuccessful sperm retrieval before micro-dissection testicular sperm extraction (micro-TESE)	N/A	N/A	Cell apoptosis, cell proliferation, and cell differentiation	-0.1	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of DQ576513 may correlated with the increased risk of Azoospermia.
PIRP00001059	28654860	piR-hsa-21530	piR-hsa-21530	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-21530 may correlated with the increased risk of Alzheimer's disease.
PIRP00001060	25305452	DQ597293	piR-hsa-27568	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ597293 may correlated with the increased risk of Bladder carcinoma.
PIRP00001061	25305452	DQ593305	piR-hsa-23568	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ593305 may correlated with the increased risk of Bladder carcinoma.
PIRP00001062	27829231	DQ596354	piR-hsa-26570	Squamous cell lung carcinoma	EFO:0000708	upregulation	poor progonosis	lung squamous cell carcinoma samples	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Squamous cell lung carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Squamous cell lung carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of DQ596354 may correlated with the poor progonosis of Squamous cell lung carcinoma.
PIRP00001063	27323410	piR-30456	piR-hsa-624	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-30456 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001064	25305452	DQ592938	piR-hsa-23216	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ592938 may correlated with the increased risk of Bladder carcinoma.
PIRP00001064	27429044	hsa_piR_016664	piR-hsa-23216	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_016664 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001065	25305452	DQ577543	piR-hsa-7817	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ577543 may correlated with the increased risk of Bladder carcinoma.
PIRP00001066	25305452	DQ600310	piR-hsa-30510	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ600310 may correlated with the increased risk of Bladder carcinoma.
PIRP00001067	28651359	DQ590013	piR-hsa-20266	Diminished ovarian reserve	EFO:0004770	downregulation	increased risk	patients with diminished ovarian reserve	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Diminished ovarian reserve was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ590013 may correlated with the increased risk of Diminished ovarian reserve.
PIRP00001068	25998508	piR-32985	piR-hsa-13196	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-32985 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001069	25305452	DQ581701	piR-hsa-11955	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ581701 may correlated with the increased risk of Bladder carcinoma.
PIRP00001070	25305452	DQ588525	piR-hsa-18837	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ588525 may correlated with the increased risk of Bladder carcinoma.
PIRP00001071	25998508	piR-32986	piR-hsa-13197	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-32986 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001072	28654860	piR-hsa-28187	piR-hsa-28187	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-28187 may correlated with the increased risk of Alzheimer's disease.
PIRP00001073	25305452	DQ575775	piR-hsa-6053	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ575775 may correlated with the increased risk of Bladder carcinoma.
PIRP00001074	25305452	DQ580653	piR-hsa-10879	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ580653 may correlated with the increased risk of Bladder carcinoma.
PIRP00001075	28654860	piR-hsa-28188	piR-hsa-28188	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-28188 may correlated with the increased risk of Alzheimer's disease.
PIRP00001076	28654860	piR-hsa-28189	piR-hsa-28189	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-28189 may correlated with the increased risk of Alzheimer's disease.
PIRP00001077	26205624	piR_011186	piR-hsa-15404	Leukemia	EFO:0000565	upregulation	increased risk	leukemia cell line U937	N/A	CDKN2B; DNMT1; Suv39H1;  EZH2	Cell cycle  and cell apoptosis	0.40	The piRNAs dysregulation associated with Leukemia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Leukemia was validated by RT-PCR. The validated results indicated that the upregulation of piR_011186 may correlated with the increased risk of Leukemia. Moreover, both molecular functions and physiological functions of piR_011186 involving in the pathologies of Leukemia are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR_011186 is possibly correlated with the increased risk of Leukemia.
PIRP00001078	29460056	DQ580288	piR-hsa-10528	Azoospermia	EFO:0000279	downregulation	increased risk	patients with nonobstructive azoospermia (NOA) between successful and unsuccessful sperm retrieval before micro-dissection testicular sperm extraction (micro-TESE)	N/A	N/A	Cell apoptosis, cell proliferation, and cell differentiation	-0.1	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of DQ580288 may correlated with the increased risk of Azoospermia.
PIRP00001079	25998508	piR-64616	piR-rno-50934	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-64616 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001080	27197292	piR-3266	piR-hsa-4668	Glioma	EFO:0005543	rs35712968	decreased risk	glioma cell	N/A	N/A	N/A	0.20	The piRNAs dysregulation associated with Glioma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Glioma was validated by RT-PCR. The validated results indicated that the rs35712968 of piR-3266 may correlated with the decreased risk of Glioma. Moreover, the molecular functions or physiological functions of piR-3266 involving in the pathologies of Glioma are illustrated in cell lines in vitro. Altogether, all above results suggested that the rs35712968 of piR-3266 is possibly correlated with the decreased risk of Glioma.
PIRP00001081	25305452	DQ589164	piR-hsa-19446	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ589164 may correlated with the increased risk of Bladder carcinoma.
PIRP00001082	26148798	DQ597347	piR-hsa-27622	Asthma	EFO:0000270	upregulation	increased risk	asthmatic patientss	N/A	N/A	Akt signaling pathway	0.10	The piRNAs dysregulation associated with Asthma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Asthma was validated by RT-PCR. The validated results indicated that the upregulation of DQ597347 may correlated with the increased risk of Asthma.
PIRP00001083	25305452	DQ596354	piR-hsa-26570	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596354 may correlated with the increased risk of Bladder carcinoma.
PIRP00001083	27429044	hsa_piR_019201	piR-hsa-26570	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_019201 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001083	27829231	DQ596354	piR-hsa-26570	Lung adenocarcinoma	EFO:0000571	upregulation	poor progonosis	lung adenocarcinoma samples	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Lung adenocarcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung adenocarcinoma was validated by RT-PCR. The validated results indicated that the upregulation of DQ596354 may correlated with the poor progonosis of Lung adenocarcinoma.
PIRP00001083	27829231	DQ596354	piR-hsa-26570	Squamous cell lung carcinoma	EFO:0000708	upregulation	poor progonosis	lung squamous cell carcinoma samples	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Squamous cell lung carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Squamous cell lung carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of DQ596354 may correlated with the poor progonosis of Squamous cell lung carcinoma.
PIRP00001084	28654860	piR-hsa-10907	piR-hsa-10907	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-10907 may correlated with the increased risk of Alzheimer's disease.
PIRP00001085	27429044	hsa_piR_020009	piR-hsa-27730	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_020009 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001086	25305452	DQ582426	piR-hsa-12649	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ582426 may correlated with the increased risk of Bladder carcinoma.
PIRP00001087	25305452	DQ596314	piR-hsa-26530	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596314 may correlated with the increased risk of Bladder carcinoma.
PIRP00001088	25305452	DQ576917	piR-hsa-7238	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ576917 may correlated with the increased risk of Bladder carcinoma.
PIRP00001088	27323410	piR-45029	piR-hsa-7238	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-45029 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001088	27429044	hsa_piR_005018	piR-hsa-7238	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_005018 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001089	27429044	hsa_piR_005019	piR-hsa-7239	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_005019 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001090	25305452	DQ596356	piR-hsa-26572	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596356 may correlated with the increased risk of Bladder carcinoma.
PIRP00001091	25305452	DQ572870	piR-hsa-3178	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ572870 may correlated with the increased risk of Bladder carcinoma.
PIRP00001092	28654860	piR-hsa-7759	piR-hsa-7759	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-7759 may correlated with the increased risk of Alzheimer's disease.
PIRP00001093	27068805	piR-31925	piR-hsa-2107	Azoospermia	EFO:0000279	downregulation	increased risk	seminal plasma of infertile patients	N/A	N/A	N/A	-0.2	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of piR-31925 may correlated with the increased risk of Azoospermia. Moreover, the molecular functions or physiological functions of piR-31925 involving in the pathologies of Azoospermia are illustrated in cell lines in vitro. Altogether, all above results suggested that the downregulation of piR-31925 is possibly correlated with the increased risk of Azoospermia.
PIRP00001094	29460056	DQ570507	piR-hsa-787	Azoospermia	EFO:0000279	downregulation	increased risk	patients with nonobstructive azoospermia (NOA) between successful and unsuccessful sperm retrieval before micro-dissection testicular sperm extraction (micro-TESE)	N/A	N/A	Cell apoptosis, cell proliferation, and cell differentiation	-0.1	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of DQ570507 may correlated with the increased risk of Azoospermia.
PIRP00001095	27197292	piR-2799	piR-hsa-4045	Glioma	EFO:0005543	rs149336947	increased risk	glioma cell	N/A	N/A	N/A	-0.2	The piRNAs dysregulation associated with Glioma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Glioma was validated by RT-PCR. The validated results indicated that the rs149336947 of piR-2799 may correlated with the increased risk of Glioma. Moreover, the molecular functions or physiological functions of piR-2799 involving in the pathologies of Glioma are illustrated in cell lines in vitro. Altogether, all above results suggested that the rs149336947 of piR-2799 is possibly correlated with the increased risk of Glioma.
PIRP00001096	25305452	DQ597696	piR-hsa-27926	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ597696 may correlated with the increased risk of Bladder carcinoma.
PIRP00001097	27429044	hsa_piR_020828	piR-hsa-28875	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_020828 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001098	25305452	DQ599994	piR-hsa-30208	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ599994 may correlated with the increased risk of Bladder carcinoma.
PIRP00001099	25313140	DQ598677	piR-hsa-28877	Breast carcinoma	EFO:0000305	upregulation	increased risk	breast cancer	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of DQ598677 may correlated with the increased risk of Breast carcinoma.
PIRP00001099	27429044	hsa_piR_020829	piR-hsa-28877	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_020829 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001100	27429044	hsa_piR_016970	piR-hsa-23655	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_016970 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001101	26265322	piR-004172	piR-hsa-5963	Seminoma	EFO:0003101	downregulation	increased risk	seminoma	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Seminoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Seminoma was validated by RT-PCR. The validated results indicated that the downregulation of piR-004172 may correlated with the increased risk of Seminoma.
PIRP00001101	26265322	piR-004172	piR-hsa-5963	Testicular germ cell tumor	EFO:1000566	downregulation	increased risk	testicular germ cell tumors	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Testicular germ cell tumor was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Testicular germ cell tumor was validated by RT-PCR. The validated results indicated that the downregulation of piR-004172 may correlated with the increased risk of Testicular germ cell tumor.
PIRP00001102	25779424	FR157678	FR157678	Gastric carcinoma	EFO:0000178	upregulation	poor progonosis	gastric cancer recurrence	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Gastric carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of FR157678 may correlated with the poor progonosis of Gastric carcinoma.
PIRP00001103	25313140	DQ597341	piR-hsa-27616	Breast carcinoma	EFO:0000305	downregulation	increased risk	breast cancer	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of DQ597341 may correlated with the increased risk of Breast carcinoma.
PIRP00001104	27429044	hsa_piR_020809	piR-hsa-28839	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_020809 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001105	25305452	DQ580006	piR-hsa-10246	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ580006 may correlated with the increased risk of Bladder carcinoma.
PIRP00001105	27429044	hsa_piR_007336	piR-hsa-10246	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_007336 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001106	25305452	DQ571849	piR-hsa-2129	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ571849 may correlated with the increased risk of Bladder carcinoma.
PIRP00001107	25305452	DQ593354	piR-hsa-23617	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ593354 may correlated with the increased risk of Bladder carcinoma.
PIRP00001108	25305452	DQ589977	piR-hsa-20230	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ589977 may correlated with the increased risk of Bladder carcinoma.
PIRP00001109	25305452	DQ587714	piR-hsa-17990	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ587714 may correlated with the increased risk of Bladder carcinoma.
PIRP00001110	27429044	hsa_piR_020498	piR-hsa-28395	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_020498 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001111	25305452	DQ591339	piR-hsa-21604	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ591339 may correlated with the increased risk of Bladder carcinoma.
PIRP00001112	23229900	piR-20582	piR-hsa-28527	Breast carcinoma	EFO:0000305	upregulation	increased risk	resected breast cancer cases	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-20582 may correlated with the increased risk of Breast carcinoma.
PIRP00001113	27429044	hsa_piR_001205	piR-hsa-1359	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_001205 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001114	27429044	hsa_piR_020657	piR-hsa-28629	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_020657 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001115	25305452	DQ590020	piR-hsa-20273	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ590020 may correlated with the increased risk of Bladder carcinoma.
PIRP00001116	28654860	piR-hsa-30518	piR-hsa-30518	Alzheimer's disease	EFO:0000249	downregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-hsa-30518 may correlated with the increased risk of Alzheimer's disease.
PIRP00001117	25305452	DQ601720	piR-hsa-31944	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ601720 may correlated with the increased risk of Bladder carcinoma.
PIRP00001118	25305452	DQ594040	piR-hsa-24274	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ594040 may correlated with the increased risk of Bladder carcinoma.
PIRP00001118	25305452	DQ594040	piR-hsa-24274	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	TNFSF4	Cell proliferation and apoptosis 	-0.4	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Bladder carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of DQ594040 may correlated with the increased risk of Bladder carcinoma. Moreover, both molecular functions and physiological functions of DQ594040 involving in the pathologies of Bladder carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the downregulation of DQ594040 is possibly correlated with the increased risk of Bladder carcinoma.
PIRP00001119	27429044	hsa_piR_020499	piR-hsa-28398	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_020499 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001120	27829231	DQ596225	piR-hsa-26441	Lung adenocarcinoma	EFO:0000571	upregulation	poor progonosis	lung adenocarcinoma samples	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Lung adenocarcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung adenocarcinoma was validated by RT-PCR. The validated results indicated that the upregulation of DQ596225 may correlated with the poor progonosis of Lung adenocarcinoma.
PIRP00001121	25305452	DQ582571	piR-hsa-12794	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ582571 may correlated with the increased risk of Bladder carcinoma.
PIRP00001122	26071182	piR-30924	piR-hsa-1077	Clear cell renal cell carcinomas	EFO:0000349	upregulation	poor progonosis	clear cell renal cell carcinomas patients	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Clear cell renal cell carcinomas was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Clear cell renal cell carcinomas was validated by RT-PCR. The validated results indicated that the upregulation of piR-30924 may correlated with the poor progonosis of Clear cell renal cell carcinomas.
PIRP00001123	27429044	hsa_piR_020450	piR-hsa-28319	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_020450 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001124	27323410	piR-43771	piR-hsa-5937	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-43771 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001125	29460056	DQ585544	piR-hsa-15839	Azoospermia	EFO:0000279	downregulation	increased risk	patients with nonobstructive azoospermia (NOA) between successful and unsuccessful sperm retrieval before micro-dissection testicular sperm extraction (micro-TESE)	N/A	N/A	Cell apoptosis, cell proliferation, and cell differentiation	-0.1	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of DQ585544 may correlated with the increased risk of Azoospermia.
PIRP00001126	28654860	piR-hsa-28771	piR-hsa-28771	Alzheimer's disease	EFO:0000249	downregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-hsa-28771 may correlated with the increased risk of Alzheimer's disease.
PIRP00001127	26071182	piR-38756	piR-hsa-30978	Clear cell renal cell carcinomas	EFO:0000349	upregulation	poor progonosis	clear cell renal cell carcinomas patients	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Clear cell renal cell carcinomas was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Clear cell renal cell carcinomas was validated by RT-PCR. The validated results indicated that the upregulation of piR-38756 may correlated with the poor progonosis of Clear cell renal cell carcinomas.
PIRP00001128	27323410	piR-43772	piR-hsa-5938	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-43772 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001129	27323410	piR-39307	piR-hsa-31511	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-39307 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001130	25305452	DQ585211	piR-hsa-15522	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ585211 may correlated with the increased risk of Bladder carcinoma.
PIRP00001131	25305452	DQ575340	piR-hsa-5632	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ575340 may correlated with the increased risk of Bladder carcinoma.
PIRP00001132	25305452	DQ587024	piR-hsa-17330	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ587024 may correlated with the increased risk of Bladder carcinoma.
PIRP00001133	25305452	DQ577470	piR-hsa-7745	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ577470 may correlated with the increased risk of Bladder carcinoma.
PIRP00001134	25305452	DQ570999	piR-hsa-1250	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ570999 may correlated with the increased risk of Bladder carcinoma.
PIRP00001135	25779424	FR387750	FR387750	Gastric carcinoma	EFO:0000178	upregulation	poor progonosis	gastric cancer recurrence	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Gastric carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of FR387750 may correlated with the poor progonosis of Gastric carcinoma.
PIRP00001136	27429044	hsa_piR_009051	piR-hsa-12487	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_009051 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001137	25305452	DQ571000	piR-hsa-1251	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ571000 may correlated with the increased risk of Bladder carcinoma.
PIRP00001138	28654860	piR-hsa-11988	piR-hsa-11988	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-11988 may correlated with the increased risk of Alzheimer's disease.
PIRP00001139	28654860	piR-hsa-11907	piR-hsa-11907	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-11907 may correlated with the increased risk of Alzheimer's disease.
PIRP00001140	25305452	DQ584252	piR-hsa-14474	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ584252 may correlated with the increased risk of Bladder carcinoma.
PIRP00001141	25305452	DQ582426	piR-hsa-12649	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ582426 may correlated with the increased risk of Bladder carcinoma.
PIRP00001142	28654860	piR-hsa-7759	piR-hsa-7759	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-7759 may correlated with the increased risk of Alzheimer's disease.
PIRP00001143	25305452	DQ580256	piR-hsa-10496	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ580256 may correlated with the increased risk of Bladder carcinoma.
PIRP00001144	27429044	hsa_piR_001205	piR-hsa-1359	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_001205 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001145	25998508	piR-32051	piR-hsa-12178	Renal cell carcinoma	EFO:0000681	upregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	0.20	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Renal cell carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-32051 may correlated with the increased risk and poor progonosis of Renal cell carcinoma. Moreover, the molecular functions or physiological functions of piR-32051 involving in the pathologies of Renal cell carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-32051 is possibly correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001146	25305452	DQ598409	piR-hsa-28610	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ598409 may correlated with the increased risk of Bladder carcinoma.
PIRP00001147	27197292	piR-598	piR-hsa-1006	Glioma	EFO:0005543	rs147061479	increased risk	glioma cell	N/A	N/A	Cell proliferation	-0.4	The piRNAs dysregulation associated with Glioma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Glioma was validated by RT-PCR. The validated results indicated that the rs147061479 of piR-598 may correlated with the increased risk of Glioma. Moreover, both molecular functions and physiological functions of piR-598 involving in the pathologies of Glioma are illustrated in cell lines in vitro. Altogether, all above results suggested that the rs147061479 of piR-598 is possibly correlated with the increased risk of Glioma.
PIRP00001148	29460056	DQ578561	piR-hsa-8802	Azoospermia	EFO:0000279	downregulation	increased risk	patients with nonobstructive azoospermia (NOA) between successful and unsuccessful sperm retrieval before micro-dissection testicular sperm extraction (micro-TESE)	N/A	N/A	Cell apoptosis, cell proliferation, and cell differentiation	-0.1	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of DQ578561 may correlated with the increased risk of Azoospermia.
PIRP00001149	23229900	piR-20365	piR-hsa-28190	Breast carcinoma	EFO:0000305	upregulation	increased risk	resected breast cancer cases	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-20365 may correlated with the increased risk of Breast carcinoma.
PIRP00001149	27323410	piR-36041	piR-hsa-28190	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36041 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001149	27429044	hsa_piR_020365	piR-hsa-28190	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_020365 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001150	28654860	piR-hsa-28116	piR-hsa-28116	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-28116 may correlated with the increased risk of Alzheimer's disease.
PIRP00001151	25305452	DQ596466	piR-hsa-26682	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ596466 may correlated with the increased risk of Bladder carcinoma.
PIRP00001152	25305452	DQ593888	piR-hsa-22915	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ593888 may correlated with the increased risk of Bladder carcinoma.
PIRP00001153	27323410	piR-31355	piR-hsa-1580	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-31355 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001154	27323410	piR-54265	piR-hsa-17444	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-54265 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001155	25305452	DQ596468	piR-hsa-26684	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ596468 may correlated with the increased risk of Bladder carcinoma.
PIRP00001156	25313140	DQ598252	piR-hsa-28467	Breast carcinoma	EFO:0000305	downregulation	increased risk	breast cancer	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of DQ598252 may correlated with the increased risk of Breast carcinoma.
PIRP00001156	25998508	piR-36318	piR-hsa-28467	Renal cell carcinoma	EFO:0000681	upregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36318 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001156	27323410	piR-36318	piR-hsa-28467	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36318 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001157	25305452	DQ589802	piR-hsa-20070	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ589802 may correlated with the increased risk of Bladder carcinoma.
PIRP00001158	25305452	DQ589977	piR-hsa-20230	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ589977 may correlated with the increased risk of Bladder carcinoma.
PIRP00001159	25305452	DQ587714	piR-hsa-17990	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ587714 may correlated with the increased risk of Bladder carcinoma.
PIRP00001160	28618124	piR-823	piR-hsa-1282	Colorectal cancer	EFO:0005842	upregulation	increased risk	colorectal cancer patients and colorectal cancer cell lines	N/A	HSF1	Cell proliferation, cell death and apoptosis	0.60	The piRNAs dysregulation associated with Colorectal cancer was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Colorectal cancer was validated by RT-PCR. The validated results indicated that the upregulation of piR-823 may correlated with the increased risk of Colorectal cancer. Moreover, both molecular functions, physiological functions and mechanisms of piR-823 involving in the pathologies of Colorectal cancer are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-823 is possibly correlated with the increased risk of Colorectal cancer.
PIRP00001161	27323410	piR-34456	piR-hsa-26606	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-34456 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001162	27323410	piR-36711	piR-hsa-28845	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-36711 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001163	28654860	piR-hsa-23848	piR-hsa-23848	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-23848 may correlated with the increased risk of Alzheimer's disease.
PIRP00001164	25305452	DQ590020	piR-hsa-20273	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ590020 may correlated with the increased risk of Bladder carcinoma.
PIRP00001165	27323410	piR-36712	piR-hsa-28846	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-36712 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001166	27429044	hsa_piR_020305	piR-hsa-28117	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_020305 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001167	26210741	piR-021285	piR-hsa-29509	Breast carcinoma	EFO:0000305	rs1326306	increased risk	breast cancer	N/A	N/A	Cell proliferation and EMT signaling pathway	-0.4	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the rs1326306 of piR-021285 may correlated with the increased risk of Breast carcinoma. Moreover, both molecular functions and physiological functions of piR-021285 involving in the pathologies of Breast carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the rs1326306 of piR-021285 is possibly correlated with the increased risk of Breast carcinoma.
PIRP00001168	25305452	DQ601720	piR-hsa-31944	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ601720 may correlated with the increased risk of Bladder carcinoma.
PIRP00001169	27323410	piR-36713	piR-hsa-28847	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36713 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001170	26071182	piR-57125	piR-hsa-20266	Clear cell renal cell carcinomas	EFO:0000349	downregulation	poor progonosis	clear cell renal cell carcinomas patients	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Clear cell renal cell carcinomas was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Clear cell renal cell carcinomas was validated by RT-PCR. The validated results indicated that the downregulation of piR-57125 may correlated with the poor progonosis of Clear cell renal cell carcinomas.
PIRP00001171	27323410	piR-36714	piR-hsa-28848	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36714 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001172	25305452	DQ598918	piR-hsa-29218	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ598918 may correlated with the increased risk of Bladder carcinoma.
PIRP00001173	28651359	DQ593354	piR-hsa-23617	Diminished ovarian reserve	EFO:0004770	downregulation	increased risk	patients with diminished ovarian reserve	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Diminished ovarian reserve was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Diminished ovarian reserve was validated by RT-PCR. The validated results indicated that the downregulation of DQ593354 may correlated with the increased risk of Diminished ovarian reserve.
PIRP00001174	27323410	piR-36715	piR-hsa-28849	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36715 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001175	26148798	DQ596390	piR-hsa-26606	Asthma	EFO:0000270	downregulation	increased risk	asthmatic patientss	N/A	N/A	Akt signaling pathway	-0.1	The piRNAs dysregulation associated with Asthma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Asthma was validated by RT-PCR. The validated results indicated that the downregulation of DQ596390 may correlated with the increased risk of Asthma.
PIRP00001176	25998508	piR-32105	piR-hsa-12232	Renal cell carcinoma	EFO:0000681	upregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-32105 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001177	25305452	DQ579146	piR-hsa-9444	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ579146 may correlated with the increased risk of Bladder carcinoma.
PIRP00001178	25305452	DQ574835	piR-hsa-5170	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ574835 may correlated with the increased risk of Bladder carcinoma.
PIRP00001179	28654860	piR-hsa-23538	piR-hsa-23538	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-23538 may correlated with the increased risk of Alzheimer's disease.
PIRP00001180	26095918	piR-L-163	piR-L-163	Non-small cell lung carcinoma	EFO:0003060	downregulation	increased risk and poor progonosis	non-small cell lung cancer (NSCLC) cell lines	N/A	p-ERM	Cell cycle  and cell migration and cell invasion	-0.6	The piRNAs dysregulation associated with Non-small cell lung carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Non-small cell lung carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of piR-L-163 may correlated with the increased risk and poor progonosis of Non-small cell lung carcinoma. Moreover, both molecular functions, physiological functions and mechanisms of piR-L-163 involving in the pathologies of Non-small cell lung carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the downregulation of piR-L-163 is possibly correlated with the increased risk and poor progonosis of Non-small cell lung carcinoma.
PIRP00001181	27323410	piR-54265	piR-hsa-17444	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-54265 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001181	27429044	hsa_piR_012681	piR-hsa-17444	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_012681 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001181	30555542	piR-54265	piR-hsa-17444	Colorectal adenocarcinoma	EFO:0000365	upregulation	increased risk	colorectal adenocarcinoma	N/A	PIWIL2	STAT3 signaling pathway, cell proliferation, metastasis and chemoresistance	0.80	The piRNAs dysregulation associated with Colorectal adenocarcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Colorectal adenocarcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-54265 may correlated with the increased risk of Colorectal adenocarcinoma. Moreover, both molecular functions, physiological functions and/or mechanisms of piR-54265 involving in the pathologies of Colorectal adenocarcinoma are illustrated in cell lines in vitro. Furthermore, the animal model experiments in vivo (eg. xenograft, transgenic) also demonstrated and supported the piR-54265 dysregulation associated with the pathologies of Colorectal adenocarcinoma. Altogether, all above results suggested that the upregulation of piR-54265 is possibly correlated with the increased risk of Colorectal adenocarcinoma.
PIRP00001182	26148798	DQ582264	piR-hsa-12487	Asthma	EFO:0000270	upregulation	increased risk	asthmatic patientss	N/A	N/A	Akt signaling pathway	0.10	The piRNAs dysregulation associated with Asthma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Asthma was validated by RT-PCR. The validated results indicated that the upregulation of DQ582264 may correlated with the increased risk of Asthma.
PIRP00001183	29460056	DQ577970	piR-hsa-8229	Azoospermia	EFO:0000279	downregulation	increased risk	patients with nonobstructive azoospermia (NOA) between successful and unsuccessful sperm retrieval before micro-dissection testicular sperm extraction (micro-TESE)	N/A	N/A	Cell apoptosis, cell proliferation, and cell differentiation	-0.1	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of DQ577970 may correlated with the increased risk of Azoospermia.
PIRP00001184	25305452	DQ588525	piR-hsa-18837	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ588525 may correlated with the increased risk of Bladder carcinoma.
PIRP00001185	27323410	piR-36241	piR-hsa-28390	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36241 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001186	27323410	piR-36074	piR-hsa-28223	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-36074 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001187	27429044	hsa_piR_001152	piR-hsa-1823	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_001152 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001188	25305452	DQ580653	piR-hsa-10879	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ580653 may correlated with the increased risk of Bladder carcinoma.
PIRP00001189	25305452	DQ587024	piR-hsa-17330	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ587024 may correlated with the increased risk of Bladder carcinoma.
PIRP00001190	25305452	DQ581440	piR-hsa-11725	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ581440 may correlated with the increased risk of Bladder carcinoma.
PIRP00001191	25305452	DQ587101	piR-hsa-17407	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ587101 may correlated with the increased risk of Bladder carcinoma.
PIRP00001192	25305452	DQ572042	piR-hsa-2322	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ572042 may correlated with the increased risk of Bladder carcinoma.
PIRP00001193	27323410	piR-36245	piR-hsa-28394	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36245 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001193	28109471	piR-36245	piR-hsa-28394	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36245 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00001194	27197292	piR-11714	piR-hsa-16119	Glioma	EFO:0005543	rs142742690	decreased risk	glioma cell	N/A	N/A	N/A	0.20	The piRNAs dysregulation associated with Glioma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Glioma was validated by RT-PCR. The validated results indicated that the rs142742690 of piR-11714 may correlated with the decreased risk of Glioma. Moreover, the molecular functions or physiological functions of piR-11714 involving in the pathologies of Glioma are illustrated in cell lines in vitro. Altogether, all above results suggested that the rs142742690 of piR-11714 is possibly correlated with the decreased risk of Glioma.
PIRP00001195	25305452	DQ575764	piR-hsa-6042	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ575764 may correlated with the increased risk of Bladder carcinoma.
PIRP00001196	27323410	piR-36246	piR-hsa-28395	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36246 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001197	25305452	DQ593702	piR-hsa-23950	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ593702 may correlated with the increased risk of Bladder carcinoma.
PIRP00001198	25305452	DQ596690	piR-hsa-26892	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ596690 may correlated with the increased risk of Bladder carcinoma.
PIRP00001199	25305452	DQ570989	piR-hsa-1240	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ570989 may correlated with the increased risk of Bladder carcinoma.
PIRP00001200	28826361	piR-40349	piR-hsa-2488	Low 2PN rates among the ICSI operators	UBERON:0000922	upregulation	decreased risk	sperm concentration and fertilization rate after ICSI	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Low 2PN rates among the ICSI operators was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Low 2PN rates among the ICSI operators was validated by RT-PCR. The validated results indicated that the upregulation of piR-40349 may correlated with the decreased risk of Low 2PN rates among the ICSI operators.
PIRP00001201	23112866	DQ601609	piR-hsa-31849	Sertoli cell-only syndrome	EFO:1001422	downregulation	increased risk	sertoli cell-only syndrome and spermatogenic failure patients	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Sertoli cell-only syndrome was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Sertoli cell-only syndrome was validated by RT-PCR. The validated results indicated that the downregulation of DQ601609 may correlated with the increased risk of Sertoli cell-only syndrome.
PIRP00001202	28654860	piR-hsa-4445	piR-hsa-4445	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-4445 may correlated with the increased risk of Alzheimer's disease.
PIRP00001203	28654860	piR-hsa-16363	piR-hsa-16363	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-16363 may correlated with the increased risk of Alzheimer's disease.
PIRP00001204	27323410	piR-33856	piR-hsa-23992	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-33856 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001205	22047710	piR-823	piR-hsa-1282	Gastric carcinoma	EFO:0000178	downregulation	increased risk	gastric cancer cells	N/A	N/A	Cell proliferation	-0.8	The piRNAs dysregulation associated with Gastric carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Gastric carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of piR-823 may correlated with the increased risk of Gastric carcinoma. Moreover, both molecular functions, physiological functions and/or mechanisms of piR-823 involving in the pathologies of Gastric carcinoma are illustrated in cell lines in vitro. Furthermore, the animal model experiments in vivo (eg. xenograft, transgenic) also demonstrated and supported the piR-823 dysregulation associated with the pathologies of Gastric carcinoma. Altogether, all above results suggested that the downregulation of piR-823 is possibly correlated with the increased risk of Gastric carcinoma.
PIRP00001205	27414029	piR-823	piR-hsa-1282	Breast carcinoma	EFO:0000305	upregulation	poor progonosis	breast cancer cell line which was malignant	N/A	N/A	Cell proliferation and EMT signaling pathway	0.20	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-823 may correlated with the poor progonosis of Breast carcinoma. Moreover, the molecular functions or physiological functions of piR-823 involving in the pathologies of Breast carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-823 is possibly correlated with the poor progonosis of Breast carcinoma.
PIRP00001205	27414029	piR-823	piR-hsa-1282	Pancreatic carcinoma	EFO:0002618	upregulation	increased risk and poor progonosis	prostate cancer cell lines	N/A	mTOR	Cell proliferation and EMT signaling pathway	0.20	The piRNAs dysregulation associated with Pancreatic carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Pancreatic carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-823 may correlated with the increased risk and poor progonosis of Pancreatic carcinoma. Moreover, the molecular functions or physiological functions of piR-823 involving in the pathologies of Pancreatic carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-823 is possibly correlated with the increased risk and poor progonosis of Pancreatic carcinoma.
PIRP00001205	27429044	hsa_piR_000823	piR-hsa-1282	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_000823 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001205	27919963	piR-823	piR-hsa-1282	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	patientss with Renal Cell Carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-823 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001206	25305452	DQ575775	piR-hsa-6053	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ575775 may correlated with the increased risk of Bladder carcinoma.
PIRP00001207	25305452	DQ594556	piR-hsa-24775	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ594556 may correlated with the increased risk of Bladder carcinoma.
PIRP00001208	28654860	piR-hsa-29114	piR-hsa-29114	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-29114 may correlated with the increased risk of Alzheimer's disease.
PIRP00001209	24247010	DQ589977	piR-hsa-20230	Testicular neoplasm	EFO:0004281	downregulation	increased risk	primary testicular tumors	N/A	N/A	N/A	-0.2	The piRNAs dysregulation associated with Testicular neoplasm was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Testicular neoplasm was validated by RT-PCR. The validated results indicated that the downregulation of DQ589977 may correlated with the increased risk of Testicular neoplasm. Moreover, the molecular functions or physiological functions of DQ589977 involving in the pathologies of Testicular neoplasm are illustrated in cell lines in vitro. Altogether, all above results suggested that the downregulation of DQ589977 is possibly correlated with the increased risk of Testicular neoplasm.
PIRP00001210	25305452	DQ597765	piR-hsa-27995	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ597765 may correlated with the increased risk of Bladder carcinoma.
PIRP00001211	25305452	DQ582294	piR-hsa-12517	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ582294 may correlated with the increased risk of Bladder carcinoma.
PIRP00001212	29460056	DQ594519	piR-hsa-24738	Azoospermia	EFO:0000279	downregulation	increased risk	patients with nonobstructive azoospermia (NOA) between successful and unsuccessful sperm retrieval before micro-dissection testicular sperm extraction (micro-TESE)	N/A	N/A	Cell apoptosis, cell proliferation, and cell differentiation	-0.1	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of DQ594519 may correlated with the increased risk of Azoospermia.
PIRP00001213	27323410	piR-43992	piR-hsa-6143	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-43992 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001214	29460056	DQ580288	piR-hsa-10528	Azoospermia	EFO:0000279	downregulation	increased risk	patients with nonobstructive azoospermia (NOA) between successful and unsuccessful sperm retrieval before micro-dissection testicular sperm extraction (micro-TESE)	N/A	N/A	Cell apoptosis, cell proliferation, and cell differentiation	-0.1	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of DQ580288 may correlated with the increased risk of Azoospermia.
PIRP00001215	25313140	DQ570994	piR-hsa-1245	Breast carcinoma	EFO:0000305	upregulation	increased risk	breast cancer	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of DQ570994 may correlated with the increased risk of Breast carcinoma.
PIRP00001216	23992744	piR-932	piR-hsa-1519	Breast carcinoma	EFO:0000305	upregulation	poor progonosis	breast cancer cell lines	N/A	N/A	EMT signaling pathway	0.20	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-932 may correlated with the poor progonosis of Breast carcinoma. Moreover, the molecular functions or physiological functions of piR-932 involving in the pathologies of Breast carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-932 is possibly correlated with the poor progonosis of Breast carcinoma.
PIRP00001217	28654860	piR-hsa-19953	piR-hsa-19953	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-19953 may correlated with the increased risk of Alzheimer's disease.
PIRP00001218	25998508	piR-34434	piR-hsa-26584	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-34434 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001219	25305452	DQ570996	piR-hsa-1247	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ570996 may correlated with the increased risk of Bladder carcinoma.
PIRP00001220	27429044	hsa_piR_011901	piR-hsa-16348	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_011901 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001221	27323410	piR-43995	piR-hsa-6146	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-43995 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001222	25305452	DQ581967	piR-hsa-12206	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ581967 may correlated with the increased risk of Bladder carcinoma.
PIRP00001223	25305452	DQ593358	piR-hsa-23621	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ593358 may correlated with the increased risk of Bladder carcinoma.
PIRP00001223	27429044	hsa_piR_016946	piR-hsa-23621	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_016946 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001224	27429044	hsa_piR_017033	piR-hsa-23786	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_017033 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001225	29460056	DQ593864	piR-hsa-24112	Azoospermia	EFO:0000279	downregulation	increased risk	patients with nonobstructive azoospermia (NOA) between successful and unsuccessful sperm retrieval before micro-dissection testicular sperm extraction (micro-TESE)	N/A	N/A	Cell apoptosis, cell proliferation, and cell differentiation	-0.1	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of DQ593864 may correlated with the increased risk of Azoospermia.
PIRP00001226	27323410	piR-43996	piR-hsa-6147	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-43996 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001227	27429044	hsa_piR_019368	piR-hsa-26819	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_019368 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001228	27429044	hsa_piR_016975	piR-hsa-23663	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_016975 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001229	28654860	piR-hsa-13408	piR-hsa-13408	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-13408 may correlated with the increased risk of Alzheimer's disease.
PIRP00001230	25998508	piR-54403	piR-hsa-17582	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-54403 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001231	28654860	piR-hsa-24887	piR-hsa-24887	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-24887 may correlated with the increased risk of Alzheimer's disease.
PIRP00001232	25998508	piR-57849	piR-hsa-21033	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-57849 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001233	25305452	DQ589358	piR-hsa-19640	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ589358 may correlated with the increased risk of Bladder carcinoma.
PIRP00001234	28654860	piR-hsa-24221	piR-hsa-24221	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-24221 may correlated with the increased risk of Alzheimer's disease.
PIRP00001235	27429044	hsa_piR_017295	piR-hsa-24143	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_017295 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001236	25305452	DQ585211	piR-hsa-15522	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ585211 may correlated with the increased risk of Bladder carcinoma.
PIRP00001237	28654860	piR-hsa-10710	piR-hsa-10710	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-10710 may correlated with the increased risk of Alzheimer's disease.
PIRP00001238	25305452	DQ583545	piR-hsa-13825	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ583545 may correlated with the increased risk of Bladder carcinoma.
PIRP00001239	25305452	DQ577347	piR-hsa-7637	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ577347 may correlated with the increased risk of Bladder carcinoma.
PIRP00001240	28826361	piR-31704	piR-hsa-1362	Idiopathic male infertility	EFO:0004248	upregulation	increased risk	sperm concentration and fertilization rate after ICSI	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Idiopathic male infertility was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Idiopathic male infertility was validated by RT-PCR. The validated results indicated that the upregulation of piR-31704 may correlated with the increased risk of Idiopathic male infertility.
PIRP00001241	25305452	DQ589839	piR-hsa-20107	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ589839 may correlated with the increased risk of Bladder carcinoma.
PIRP00001242	25305452	DQ581440	piR-hsa-11725	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ581440 may correlated with the increased risk of Bladder carcinoma.
PIRP00001243	25305452	DQ600288	piR-hsa-30488	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ600288 may correlated with the increased risk of Bladder carcinoma.
PIRP00001244	29460056	DQ585544	piR-hsa-15839	Azoospermia	EFO:0000279	downregulation	increased risk	patients with nonobstructive azoospermia (NOA) between successful and unsuccessful sperm retrieval before micro-dissection testicular sperm extraction (micro-TESE)	N/A	N/A	Cell apoptosis, cell proliferation, and cell differentiation	-0.1	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of DQ585544 may correlated with the increased risk of Azoospermia.
PIRP00001245	25305452	DQ600289	piR-hsa-30489	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ600289 may correlated with the increased risk of Bladder carcinoma.
PIRP00001246	25305452	DQ580927	piR-hsa-11256	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ580927 may correlated with the increased risk of Bladder carcinoma.
PIRP00001246	27429044	hsa_piR_008033	piR-hsa-11256	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_008033 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001247	25305452	DQ577000	piR-hsa-7319	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ577000 may correlated with the increased risk of Bladder carcinoma.
PIRP00001248	27429044	hsa_piR_005076	piR-hsa-7327	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_005076 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001249	25305452	DQ599906	piR-hsa-30134	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ599906 may correlated with the increased risk of Bladder carcinoma.
PIRP00001250	27429044	hsa_piR_020009	piR-hsa-27730	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_020009 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001251	25305452	DQ596690	piR-hsa-26892	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ596690 may correlated with the increased risk of Bladder carcinoma.
PIRP00001252	25305452	DQ599922	piR-hsa-30136	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ599922 may correlated with the increased risk of Bladder carcinoma.
PIRP00001253	25305452	DQ597651	piR-hsa-27896	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ597651 may correlated with the increased risk of Bladder carcinoma.
PIRP00001254	28654860	piR-hsa-26156	piR-hsa-26156	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-26156 may correlated with the increased risk of Alzheimer's disease.
PIRP00001255	28654860	piR-hsa-4685	piR-hsa-4685	Alzheimer's disease	EFO:0000249	downregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-hsa-4685 may correlated with the increased risk of Alzheimer's disease.
PIRP00001256	25305452	DQ600951	piR-hsa-31237	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ600951 may correlated with the increased risk of Bladder carcinoma.
PIRP00001257	27323410	piR-61919	piR-hsa-26039	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-61919 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001258	25779046	pi-sno75	pi-sno75	Breast carcinoma	EFO:0000305	downregulation	increased risk	breast cancer cells	N/A	TRAIL	hCOMPASS-like complexes	-0.8	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of pi-sno75 may correlated with the increased risk of Breast carcinoma. Moreover, both molecular functions, physiological functions and/or mechanisms of pi-sno75 involving in the pathologies of Breast carcinoma are illustrated in cell lines in vitro. Furthermore, the animal model experiments in vivo (eg. xenograft, transgenic) also demonstrated and supported the pi-sno75 dysregulation associated with the pathologies of Breast carcinoma. Altogether, all above results suggested that the downregulation of pi-sno75 is possibly correlated with the increased risk of Breast carcinoma.
PIRP00001259	25305452	DQ600952	piR-hsa-31238	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ600952 may correlated with the increased risk of Bladder carcinoma.
PIRP00001260	25305452	DQ596111	piR-hsa-26343	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596111 may correlated with the increased risk of Bladder carcinoma.
PIRP00001261	27323410	piR-30456	piR-hsa-624	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-30456 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001261	27429044	hsa_piR_000291	piR-hsa-624	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_000291 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001262	25305452	DQ590455	piR-hsa-20664	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ590455 may correlated with the increased risk of Bladder carcinoma.
PIRP00001263	25313140	DQ597341	piR-hsa-27616	Breast carcinoma	EFO:0000305	downregulation	increased risk	breast cancer	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of DQ597341 may correlated with the increased risk of Breast carcinoma.
PIRP00001264	25305452	DQ591460	piR-hsa-21724	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ591460 may correlated with the increased risk of Bladder carcinoma.
PIRP00001265	23229900	piR-20485	piR-hsa-28374	Breast carcinoma	EFO:0000305	upregulation	increased risk	resected breast cancer cases	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-20485 may correlated with the increased risk of Breast carcinoma.
PIRP00001266	25998508	piR-45808	piR-hsa-7955	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-45808 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001267	25998508	piR-45809	piR-hsa-7956	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-45809 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001268	27829231	DQ596306	piR-hsa-26522	Lung adenocarcinoma	EFO:0000571	upregulation	poor progonosis	lung adenocarcinoma samples	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Lung adenocarcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung adenocarcinoma was validated by RT-PCR. The validated results indicated that the upregulation of DQ596306 may correlated with the poor progonosis of Lung adenocarcinoma.
PIRP00001269	25305452	DQ597833	piR-hsa-28063	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ597833 may correlated with the increased risk of Bladder carcinoma.
PIRP00001270	25305452	DQ601720	piR-hsa-31944	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ601720 may correlated with the increased risk of Bladder carcinoma.
PIRP00001271	25305452	DQ589358	piR-hsa-19640	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ589358 may correlated with the increased risk of Bladder carcinoma.
PIRP00001272	25998508	piR-54542	piR-hsa-17720	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-54542 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001273	27323410	piR-61919	piR-hsa-26039	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-61919 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001274	27323410	piR-31531	piR-hsa-1742	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-31531 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001275	26265322	piR-006113	piR-hsa-8632	Seminoma	EFO:0003101	downregulation	increased risk	seminoma	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Seminoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Seminoma was validated by RT-PCR. The validated results indicated that the downregulation of piR-006113 may correlated with the increased risk of Seminoma.
PIRP00001275	26265322	piR-006113	piR-hsa-8632	Testicular germ cell tumor	EFO:1000566	downregulation	increased risk	testicular germ cell tumors	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Testicular germ cell tumor was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Testicular germ cell tumor was validated by RT-PCR. The validated results indicated that the downregulation of piR-006113 may correlated with the increased risk of Testicular germ cell tumor.
PIRP00001276	27829231	DQ596309	piR-hsa-26525	Lung adenocarcinoma	EFO:0000571	upregulation	poor progonosis	lung adenocarcinoma samples	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Lung adenocarcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung adenocarcinoma was validated by RT-PCR. The validated results indicated that the upregulation of DQ596309 may correlated with the poor progonosis of Lung adenocarcinoma.
PIRP00001277	28423657	piR-46545	piR-hsa-8674	Breast carcinoma	EFO:0000305	downregulation	increased risk	breast cancer cell lines	N/A	N/A	AMPK signaling pathway	-0.05	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-46545 may correlated with the increased risk of Breast carcinoma.
PIRP00001277	28423657	piR-46545	piR-hsa-8674	Lung carcinoma	EFO:0001071	downregulation	increased risk	lung cancer patients and lung cancer cell lines	N/A	AMPK	AMPK signaling pathway	-0.4	The piRNAs dysregulation associated with Lung carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of piR-46545 may correlated with the increased risk of Lung carcinoma. Moreover, both molecular functions and physiological functions of piR-46545 involving in the pathologies of Lung carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the downregulation of piR-46545 is possibly correlated with the increased risk of Lung carcinoma.
PIRP00001278	27323410	piR-45029	piR-hsa-7238	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-45029 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001279	28109471	NONHSAT067200	NONHSAT067200	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	tobacco	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of NONHSAT067200 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00001280	25305452	DQ581730	piR-hsa-11984	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ581730 may correlated with the increased risk of Bladder carcinoma.
PIRP00001281	25998508	piR-4018	piR-hsa-5748	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-4018 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001282	28654860	piR-hsa-5952	piR-hsa-5952	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-5952 may correlated with the increased risk of Alzheimer's disease.
PIRP00001283	25305452	DQ571328	piR-hsa-1331	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ571328 may correlated with the increased risk of Bladder carcinoma.
PIRP00001284	25305452	DQ588363	piR-hsa-18594	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ588363 may correlated with the increased risk of Bladder carcinoma.
PIRP00001285	27323410	piR-36716	piR-hsa-28850	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36716 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001285	27429044	hsa_piR_020814	piR-hsa-28850	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_020814 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001286	25305452	DQ571140	piR-hsa-1477	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ571140 may correlated with the increased risk of Bladder carcinoma.
PIRP00001287	25305452	DQ574835	piR-hsa-5170	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ574835 may correlated with the increased risk of Bladder carcinoma.
PIRP00001288	28654860	piR-hsa-20271	piR-hsa-20271	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-20271 may correlated with the increased risk of Alzheimer's disease.
PIRP00001289	25305452	DQ600288	piR-hsa-30488	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ600288 may correlated with the increased risk of Bladder carcinoma.
PIRP00001290	27323410	piR-49143	piR-hsa-11360	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-49143 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001291	25305452	DQ600289	piR-hsa-30489	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ600289 may correlated with the increased risk of Bladder carcinoma.
PIRP00001292	27323410	piR-49144	piR-hsa-11361	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-49144 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001293	25305452	DQ599906	piR-hsa-30134	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ599906 may correlated with the increased risk of Bladder carcinoma.
PIRP00001294	28654860	piR-hsa-5959	piR-hsa-5959	Alzheimer's disease	EFO:0000249	downregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-hsa-5959 may correlated with the increased risk of Alzheimer's disease.
PIRP00001295	27323410	piR-49145	piR-hsa-11362	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-49145 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00001295	28109471	piR-49145	piR-hsa-11362	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-49145 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00001296	28654860	piR-hsa-5645	piR-hsa-5645	Alzheimer's disease	EFO:0000249	downregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-hsa-5645 may correlated with the increased risk of Alzheimer's disease.
PIRP00001297	27323410	piR-39307	piR-hsa-31511	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-39307 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001298	25305452	DQ594556	piR-hsa-24775	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ594556 may correlated with the increased risk of Bladder carcinoma.
PIRP00001298	27429044	hsa_piR_017791	piR-hsa-24775	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_017791 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001299	25305452	DQ599922	piR-hsa-30136	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ599922 may correlated with the increased risk of Bladder carcinoma.
PIRP00001300	25305452	DQ597651	piR-hsa-27896	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ597651 may correlated with the increased risk of Bladder carcinoma.
PIRP00001301	29460056	DQ596250	piR-hsa-26466	Azoospermia	EFO:0000279	downregulation	increased risk	patients with nonobstructive azoospermia (NOA) between successful and unsuccessful sperm retrieval before micro-dissection testicular sperm extraction (micro-TESE)	N/A	N/A	Cell apoptosis, cell proliferation, and cell differentiation	-0.1	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of DQ596250 may correlated with the increased risk of Azoospermia.
PIRP00001302	27323410	piR-35221	piR-hsa-27124	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-35221 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001303	27429044	hsa_piR_013306	piR-hsa-18287	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_013306 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001304	28654860	piR-hsa-15406	piR-hsa-15406	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-15406 may correlated with the increased risk of Alzheimer's disease.
PIRP00001305	25998508	piR-32051	piR-hsa-12178	Renal cell carcinoma	EFO:0000681	upregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	0.20	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Renal cell carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-32051 may correlated with the increased risk and poor progonosis of Renal cell carcinoma. Moreover, the molecular functions or physiological functions of piR-32051 involving in the pathologies of Renal cell carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-32051 is possibly correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001306	28654860	piR-hsa-30518	piR-hsa-30518	Alzheimer's disease	EFO:0000249	downregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-hsa-30518 may correlated with the increased risk of Alzheimer's disease.
PIRP00001307	27323410	piR-36082	piR-hsa-28231	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36082 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001308	23229900	piR-20365	piR-hsa-28190	Breast carcinoma	EFO:0000305	upregulation	increased risk	resected breast cancer cases	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-20365 may correlated with the increased risk of Breast carcinoma.
PIRP00001308	27323410	piR-36041	piR-hsa-28190	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36041 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001308	27429044	hsa_piR_020365	piR-hsa-28190	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_020365 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001309	28423657	piR-52200	piR-hsa-15399	Lung carcinoma	EFO:0001071	upregulation	increased risk	lung cancer patients and lung cancer cell lines	N/A	AMPK	AMPK signaling pathway	0.40	The piRNAs dysregulation associated with Lung carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-52200 may correlated with the increased risk of Lung carcinoma. Moreover, both molecular functions and physiological functions of piR-52200 involving in the pathologies of Lung carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-52200 is possibly correlated with the increased risk of Lung carcinoma.
PIRP00001310	25305452	DQ598373	piR-hsa-28588	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ598373 may correlated with the increased risk of Bladder carcinoma.
PIRP00001311	28654860	piR-hsa-9378	piR-hsa-9378	Alzheimer's disease	EFO:0000249	downregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-hsa-9378 may correlated with the increased risk of Alzheimer's disease.
PIRP00001312	25305452	DQ590455	piR-hsa-20664	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ590455 may correlated with the increased risk of Bladder carcinoma.
PIRP00001313	25313140	DQ598252	piR-hsa-28467	Breast carcinoma	EFO:0000305	downregulation	increased risk	breast cancer	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of DQ598252 may correlated with the increased risk of Breast carcinoma.
PIRP00001313	25998508	piR-36318	piR-hsa-28467	Renal cell carcinoma	EFO:0000681	upregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36318 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001313	27323410	piR-36318	piR-hsa-28467	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36318 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001314	27323410	piR-43771	piR-hsa-5937	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-43771 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001315	25305452	DQ598294	piR-hsa-28509	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ598294 may correlated with the increased risk of Bladder carcinoma.
PIRP00001316	27323410	piR-43772	piR-hsa-5938	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-43772 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001317	29460056	DQ578561	piR-hsa-8802	Azoospermia	EFO:0000279	downregulation	increased risk	patients with nonobstructive azoospermia (NOA) between successful and unsuccessful sperm retrieval before micro-dissection testicular sperm extraction (micro-TESE)	N/A	N/A	Cell apoptosis, cell proliferation, and cell differentiation	-0.1	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of DQ578561 may correlated with the increased risk of Azoospermia.
PIRP00001318	28654860	piR-hsa-11139	piR-hsa-11139	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-11139 may correlated with the increased risk of Alzheimer's disease.
PIRP00001319	27429044	hsa_piR_018165	piR-hsa-25313	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_018165 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001320	29460056	DQ594519	piR-hsa-24738	Azoospermia	EFO:0000279	downregulation	increased risk	patients with nonobstructive azoospermia (NOA) between successful and unsuccessful sperm retrieval before micro-dissection testicular sperm extraction (micro-TESE)	N/A	N/A	Cell apoptosis, cell proliferation, and cell differentiation	-0.1	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of DQ594519 may correlated with the increased risk of Azoospermia.
PIRP00001321	28423657	piR-46545	piR-hsa-8674	Breast carcinoma	EFO:0000305	downregulation	increased risk	breast cancer cell lines	N/A	N/A	AMPK signaling pathway	-0.05	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-46545 may correlated with the increased risk of Breast carcinoma.
PIRP00001322	29460056	DQ598210	piR-hsa-28425	Azoospermia	EFO:0000279	downregulation	increased risk	patients with nonobstructive azoospermia (NOA) between successful and unsuccessful sperm retrieval before micro-dissection testicular sperm extraction (micro-TESE)	N/A	N/A	Cell apoptosis, cell proliferation, and cell differentiation	-0.1	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of DQ598210 may correlated with the increased risk of Azoospermia.
PIRP00001323	27919963	piR-823	piR-hsa-1282	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	patientss with Renal Cell Carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-823 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001324	25305452	DQ596282	piR-hsa-26498	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596282 may correlated with the increased risk of Bladder carcinoma.
PIRP00001325	25305452	DQ585585	piR-hsa-15880	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ585585 may correlated with the increased risk of Bladder carcinoma.
PIRP00001326	27429044	hsa_piR_020305	piR-hsa-28117	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_020305 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001327	29460056	DQ593864	piR-hsa-24112	Azoospermia	EFO:0000279	downregulation	increased risk	patients with nonobstructive azoospermia (NOA) between successful and unsuccessful sperm retrieval before micro-dissection testicular sperm extraction (micro-TESE)	N/A	N/A	Cell apoptosis, cell proliferation, and cell differentiation	-0.1	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of DQ593864 may correlated with the increased risk of Azoospermia.
PIRP00001328	25305452	DQ585568	piR-hsa-15863	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ585568 may correlated with the increased risk of Bladder carcinoma.
PIRP00001329	25305452	DQ585569	piR-hsa-15864	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ585569 may correlated with the increased risk of Bladder carcinoma.
PIRP00001330	25305452	DQ579049	piR-hsa-9361	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ579049 may correlated with the increased risk of Bladder carcinoma.
PIRP00001331	25305452	DQ586986	piR-hsa-17292	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ586986 may correlated with the increased risk of Bladder carcinoma.
PIRP00001332	25305452	DQ572051	piR-hsa-2331	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ572051 may correlated with the increased risk of Bladder carcinoma.
PIRP00001333	28654860	piR-hsa-5952	piR-hsa-5952	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-5952 may correlated with the increased risk of Alzheimer's disease.
PIRP00001334	26071182	piR-38756	piR-hsa-30978	Clear cell renal cell carcinomas	EFO:0000349	upregulation	poor progonosis	clear cell renal cell carcinomas patients	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Clear cell renal cell carcinomas was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Clear cell renal cell carcinomas was validated by RT-PCR. The validated results indicated that the upregulation of piR-38756 may correlated with the poor progonosis of Clear cell renal cell carcinomas.
PIRP00001335	25305452	DQ585261	piR-hsa-15572	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ585261 may correlated with the increased risk of Bladder carcinoma.
PIRP00001336	28654860	piR-hsa-10106	piR-hsa-10106	Alzheimer's disease	EFO:0000249	downregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-hsa-10106 may correlated with the increased risk of Alzheimer's disease.
PIRP00001337	25305452	DQ575340	piR-hsa-5632	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ575340 may correlated with the increased risk of Bladder carcinoma.
PIRP00001338	28654860	piR-hsa-14148	piR-hsa-14148	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-14148 may correlated with the increased risk of Alzheimer's disease.
PIRP00001339	25305452	DQ574993	piR-hsa-5299	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ574993 may correlated with the increased risk of Bladder carcinoma.
PIRP00001340	25305452	DQ585286	piR-hsa-15597	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ585286 may correlated with the increased risk of Bladder carcinoma.
PIRP00001341	25998508	piR-39894	piR-hsa-32052	Renal cell carcinoma	EFO:0000681	upregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	0.20	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Renal cell carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-39894 may correlated with the increased risk and poor progonosis of Renal cell carcinoma. Moreover, the molecular functions or physiological functions of piR-39894 involving in the pathologies of Renal cell carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-39894 is possibly correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001342	23376363	piR-Hep1	piR-hsa-8438265	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	hepatocellular carcinoma patients and  hepatocellular lines	N/A	Akt	Akt signaling pathway	0.40	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Hepatocellular carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-Hep1 may correlated with the increased risk of Hepatocellular carcinoma. Moreover, both molecular functions and physiological functions of piR-Hep1 involving in the pathologies of Hepatocellular carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-Hep1 is possibly correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001343	25305452	DQ585287	piR-hsa-15598	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ585287 may correlated with the increased risk of Bladder carcinoma.
PIRP00001344	29460056	DQ577970	piR-hsa-8229	Azoospermia	EFO:0000279	downregulation	increased risk	patients with nonobstructive azoospermia (NOA) between successful and unsuccessful sperm retrieval before micro-dissection testicular sperm extraction (micro-TESE)	N/A	N/A	Cell apoptosis, cell proliferation, and cell differentiation	-0.1	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of DQ577970 may correlated with the increased risk of Azoospermia.
PIRP00001345	28654860	piR-hsa-5959	piR-hsa-5959	Alzheimer's disease	EFO:0000249	downregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-hsa-5959 may correlated with the increased risk of Alzheimer's disease.
PIRP00001346	28654860	piR-hsa-5645	piR-hsa-5645	Alzheimer's disease	EFO:0000249	downregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-hsa-5645 may correlated with the increased risk of Alzheimer's disease.
PIRP00001347	25305452	DQ570657	piR-hsa-922	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ570657 may correlated with the increased risk of Bladder carcinoma.
PIRP00001348	25305452	DQ571849	piR-hsa-2129	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ571849 may correlated with the increased risk of Bladder carcinoma.
PIRP00001349	27429044	hsa_piR_017061	piR-hsa-23822	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_017061 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001350	25305452	DQ588925	piR-hsa-19207	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ588925 may correlated with the increased risk of Bladder carcinoma.
PIRP00001351	26265322	piR-004172	piR-hsa-5963	Seminoma	EFO:0003101	downregulation	increased risk	seminoma	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Seminoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Seminoma was validated by RT-PCR. The validated results indicated that the downregulation of piR-004172 may correlated with the increased risk of Seminoma.
PIRP00001352	27429044	hsa_piR_019822	piR-hsa-27490	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_019822 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001353	27429044	hsa_piR_019824	piR-hsa-27492	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_019824 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001354	25779424	FR064000	FR064000	Gastric carcinoma	EFO:0000178	upregulation	poor progonosis	gastric cancer recurrence	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Gastric carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of FR064000 may correlated with the poor progonosis of Gastric carcinoma.
PIRP00001355	25305452	DQ598373	piR-hsa-28588	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ598373 may correlated with the increased risk of Bladder carcinoma.
PIRP00001356	25998508	piR-4018	piR-hsa-5748	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-4018 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001357	23229900	piR-19825	piR-hsa-27493	Breast carcinoma	EFO:0000305	upregulation	increased risk	resected breast cancer cases	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-19825 may correlated with the increased risk of Breast carcinoma.
PIRP00001357	27323410	piR-35284	piR-hsa-27493	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-35284 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001358	25305452	DQ593538	piR-hsa-23786	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ593538 may correlated with the increased risk of Bladder carcinoma.
PIRP00001358	27429044	hsa_piR_017033	piR-hsa-23786	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_017033 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001359	25305452	DQ594040	piR-hsa-24274	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ594040 may correlated with the increased risk of Bladder carcinoma.
PIRP00001359	25305452	DQ594040	piR-hsa-24274	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	TNFSF4	Cell proliferation and apoptosis 	-0.4	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Bladder carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of DQ594040 may correlated with the increased risk of Bladder carcinoma. Moreover, both molecular functions and physiological functions of DQ594040 involving in the pathologies of Bladder carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the downregulation of DQ594040 is possibly correlated with the increased risk of Bladder carcinoma.
PIRP00001360	25305452	DQ591143	piR-hsa-20887	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ591143 may correlated with the increased risk of Bladder carcinoma.
PIRP00001361	27429044	hsa_piR_021214	piR-hsa-29114	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_021214 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001362	25305452	DQ598294	piR-hsa-28509	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ598294 may correlated with the increased risk of Bladder carcinoma.
PIRP00001363	28654860	piR-hsa-11726	piR-hsa-11726	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-11726 may correlated with the increased risk of Alzheimer's disease.
PIRP00001364	29382334	piR-26525	piR-26525	Colorectal cancer	EFO:0005842	downregulation	increased risk and poor progonosis	colorectal cancer patients	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Colorectal cancer was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Colorectal cancer was validated by RT-PCR. The validated results indicated that the downregulation of piR-26525 may correlated with the increased risk and poor progonosis of Colorectal cancer.
PIRP00001365	27323410	piR-35469	piR-hsa-27140	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-35469 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001365	27429044	hsa_piR_019951	piR-hsa-27140	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_019951 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001366	28654860	piR-hsa-18061	piR-hsa-18061	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-18061 may correlated with the increased risk of Alzheimer's disease.
PIRP00001367	25305452	DQ596128	piR-hsa-26359	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596128 may correlated with the increased risk of Bladder carcinoma.
PIRP00001368	25305452	DQ589358	piR-hsa-19640	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ589358 may correlated with the increased risk of Bladder carcinoma.
PIRP00001369	25305452	DQ581701	piR-hsa-11955	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ581701 may correlated with the increased risk of Bladder carcinoma.
PIRP00001370	27323410	piR-54907	piR-hsa-18071	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-54907 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001371	25998508	piR-57849	piR-hsa-21033	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-57849 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001372	27429044	hsa_piR_010155	piR-hsa-13940	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_010155 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001373	25305452	DQ577470	piR-hsa-7745	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ577470 may correlated with the increased risk of Bladder carcinoma.
PIRP00001374	25305452	DQ577740	piR-hsa-7999	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ577740 may correlated with the increased risk of Bladder carcinoma.
PIRP00001375	28651359	DQ598252	piR-hsa-28467	Diminished ovarian reserve	EFO:0004770	upregulation	increased risk	patients with diminished ovarian reserve	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Diminished ovarian reserve was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Diminished ovarian reserve was validated by RT-PCR. The validated results indicated that the upregulation of DQ598252 may correlated with the increased risk of Diminished ovarian reserve.
PIRP00001376	25305452	DQ583718	piR-hsa-13984	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ583718 may correlated with the increased risk of Bladder carcinoma.
PIRP00001377	26071182	piR-57125	piR-hsa-20266	Clear cell renal cell carcinomas	EFO:0000349	downregulation	poor progonosis	clear cell renal cell carcinomas patients	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Clear cell renal cell carcinomas was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Clear cell renal cell carcinomas was validated by RT-PCR. The validated results indicated that the downregulation of piR-57125 may correlated with the poor progonosis of Clear cell renal cell carcinomas.
PIRP00001377	27323410	piR-57125	piR-hsa-20266	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-57125 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00001377	27429044	hsa_piR_014620	piR-hsa-20266	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_014620 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001377	28460486	piR-57125	piR-hsa-20266	Lung adenocarcinoma	EFO:0000571	downregulation	poor progonosis	lung adenocarcinoma	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Lung adenocarcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung adenocarcinoma was validated by RT-PCR. The validated results indicated that the downregulation of piR-57125 may correlated with the poor progonosis of Lung adenocarcinoma.
PIRP00001378	27323410	piR-34440	piR-hsa-26590	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-34440 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001379	25779424	FR387750	FR387750	Gastric carcinoma	EFO:0000178	upregulation	poor progonosis	gastric cancer recurrence	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Gastric carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of FR387750 may correlated with the poor progonosis of Gastric carcinoma.
PIRP00001380	27429044	hsa_piR_023057	piR-hsa-31766	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_023057 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001381	28654860	piR-hsa-7681	piR-hsa-7681	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-7681 may correlated with the increased risk of Alzheimer's disease.
PIRP00001382	25779424	FR381169	FR381169	Gastric carcinoma	EFO:0000178	upregulation	poor progonosis	gastric cancer recurrence	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Gastric carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of FR381169 may correlated with the poor progonosis of Gastric carcinoma.
PIRP00001383	25305452	DQ600079	piR-hsa-30293	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ600079 may correlated with the increased risk of Bladder carcinoma.
PIRP00001384	25779424	FR381169	FR381169	Gastric carcinoma	EFO:0000178	upregulation	poor progonosis	gastric cancer recurrence	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Gastric carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of FR381169 may correlated with the poor progonosis of Gastric carcinoma.
PIRP00001385	25305452	DQ580256	piR-hsa-10496	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ580256 may correlated with the increased risk of Bladder carcinoma.
PIRP00001386	25305452	DQ583325	piR-hsa-13634	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ583325 may correlated with the increased risk of Bladder carcinoma.
PIRP00001387	28826361	piR-31704	piR-hsa-1362	Idiopathic male infertility	EFO:0004248	upregulation	increased risk	sperm concentration and fertilization rate after ICSI	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Idiopathic male infertility was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Idiopathic male infertility was validated by RT-PCR. The validated results indicated that the upregulation of piR-31704 may correlated with the increased risk of Idiopathic male infertility.
PIRP00001388	23112866	DQ598918	piR-hsa-29218	Sertoli cell-only syndrome	EFO:1001422	downregulation	increased risk	sertoli cell-only syndrome and spermatogenic failure patients	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Sertoli cell-only syndrome was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Sertoli cell-only syndrome was validated by RT-PCR. The validated results indicated that the downregulation of DQ598918 may correlated with the increased risk of Sertoli cell-only syndrome.
PIRP00001389	25305452	DQ572042	piR-hsa-2322	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ572042 may correlated with the increased risk of Bladder carcinoma.
PIRP00001390	25305452	DQ600288	piR-hsa-30488	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ600288 may correlated with the increased risk of Bladder carcinoma.
PIRP00001391	28654860	piR-hsa-3645	piR-hsa-3645	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-3645 may correlated with the increased risk of Alzheimer's disease.
PIRP00001392	27429044	hsa_piR_001152	piR-hsa-1823	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_001152 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001393	27429044	hsa_piR_010894	piR-hsa-15023	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_010894 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001394	25305452	DQ600289	piR-hsa-30489	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ600289 may correlated with the increased risk of Bladder carcinoma.
PIRP00001395	29460056	DQ598210	piR-hsa-28425	Azoospermia	EFO:0000279	downregulation	increased risk	patients with nonobstructive azoospermia (NOA) between successful and unsuccessful sperm retrieval before micro-dissection testicular sperm extraction (micro-TESE)	N/A	N/A	Cell apoptosis, cell proliferation, and cell differentiation	-0.1	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of DQ598210 may correlated with the increased risk of Azoospermia.
PIRP00001396	25305452	DQ599906	piR-hsa-30134	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ599906 may correlated with the increased risk of Bladder carcinoma.
PIRP00001397	25305452	DQ572870	piR-hsa-3178	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ572870 may correlated with the increased risk of Bladder carcinoma.
PIRP00001398	27429044	hsa_piR_019914	piR-hsa-27622	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_019914 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001399	25305452	DQ599922	piR-hsa-30136	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ599922 may correlated with the increased risk of Bladder carcinoma.
PIRP00001400	25305452	DQ597651	piR-hsa-27896	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ597651 may correlated with the increased risk of Bladder carcinoma.
PIRP00001401	25305452	DQ597100	piR-hsa-27390	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ597100 may correlated with the increased risk of Bladder carcinoma.
PIRP00001402	25305452	DQ575775	piR-hsa-6053	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ575775 may correlated with the increased risk of Bladder carcinoma.
PIRP00001403	25305452	DQ597101	piR-hsa-27391	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ597101 may correlated with the increased risk of Bladder carcinoma.
PIRP00001404	28654860	piR-hsa-30713	piR-hsa-30713	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-30713 may correlated with the increased risk of Alzheimer's disease.
PIRP00001405	28423657	piR-35127	piR-hsa-27351	Breast carcinoma	EFO:0000305	downregulation	increased risk	breast cancer cell lines	N/A	N/A	AMPK signaling pathway	-0.05	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-35127 may correlated with the increased risk of Breast carcinoma.
PIRP00001405	28423657	piR-35127	piR-hsa-27351	Lung carcinoma	EFO:0001071	downregulation	increased risk	lung cancer patients and lung cancer cell lines	N/A	AMPK	AMPK signaling pathway	-0.4	The piRNAs dysregulation associated with Lung carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of piR-35127 may correlated with the increased risk of Lung carcinoma. Moreover, both molecular functions and physiological functions of piR-35127 involving in the pathologies of Lung carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the downregulation of piR-35127 is possibly correlated with the increased risk of Lung carcinoma.
PIRP00001406	27429044	hsa_piR_000823	piR-hsa-1282	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_000823 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001407	28651359	DQ571813	piR-hsa-2107	Diminished ovarian reserve	EFO:0004770	downregulation	increased risk	patients with diminished ovarian reserve	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Diminished ovarian reserve was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Diminished ovarian reserve was validated by RT-PCR. The validated results indicated that the downregulation of DQ571813 may correlated with the increased risk of Diminished ovarian reserve.
PIRP00001408	28654860	piR-hsa-25652	piR-hsa-25652	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-25652 may correlated with the increased risk of Alzheimer's disease.
PIRP00001409	28654860	piR-hsa-16724	piR-hsa-16724	Alzheimer's disease	EFO:0000249	downregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-hsa-16724 may correlated with the increased risk of Alzheimer's disease.
PIRP00001410	28460486	piR-57125	piR-hsa-20266	Lung adenocarcinoma	EFO:0000571	downregulation	poor progonosis	lung adenocarcinoma	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Lung adenocarcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung adenocarcinoma was validated by RT-PCR. The validated results indicated that the downregulation of piR-57125 may correlated with the poor progonosis of Lung adenocarcinoma.
PIRP00001411	29460056	DQ596250	piR-hsa-26466	Azoospermia	EFO:0000279	downregulation	increased risk	patients with nonobstructive azoospermia (NOA) between successful and unsuccessful sperm retrieval before micro-dissection testicular sperm extraction (micro-TESE)	N/A	N/A	Cell apoptosis, cell proliferation, and cell differentiation	-0.1	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of DQ596250 may correlated with the increased risk of Azoospermia.
PIRP00001412	27429044	hsa_piR_020362	piR-hsa-28183	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_020362 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001413	28654860	piR-hsa-25384	piR-hsa-25384	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-25384 may correlated with the increased risk of Alzheimer's disease.
PIRP00001414	27429044	hsa_piR_020363	piR-hsa-28185	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_020363 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001415	27429044	hsa_piR_020364	piR-hsa-28186	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_020364 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001416	27429044	hsa_piR_001152	piR-hsa-1823	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_001152 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001417	25305452	DQ596128	piR-hsa-26359	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596128 may correlated with the increased risk of Bladder carcinoma.
PIRP00001418	27323410	piR-36038	piR-hsa-28187	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36038 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001419	25305452	DQ574109	piR-hsa-4371	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ574109 may correlated with the increased risk of Bladder carcinoma.
PIRP00001420	27323410	piR-36039	piR-hsa-28188	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36039 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001421	28423657	piR-34871	piR-hsa-27007	Breast carcinoma	EFO:0000305	upregulation	increased risk	breast cancer cell lines	N/A	N/A	AMPK signaling pathway	0.05	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-34871 may correlated with the increased risk of Breast carcinoma.
PIRP00001421	28423657	piR-34871	piR-hsa-27007	Lung carcinoma	EFO:0001071	upregulation	increased risk	lung cancer patients and lung cancer cell lines	N/A	AMPK	AMPK signaling pathway	0.40	The piRNAs dysregulation associated with Lung carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-34871 may correlated with the increased risk of Lung carcinoma. Moreover, both molecular functions and physiological functions of piR-34871 involving in the pathologies of Lung carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-34871 is possibly correlated with the increased risk of Lung carcinoma.
PIRP00001422	28654860	piR-hsa-25074	piR-hsa-25074	Alzheimer's disease	EFO:0000249	downregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-hsa-25074 may correlated with the increased risk of Alzheimer's disease.
PIRP00001423	27323410	piR-36040	piR-hsa-28189	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36040 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001424	25305452	DQ588688	piR-hsa-18985	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ588688 may correlated with the increased risk of Bladder carcinoma.
PIRP00001425	28654860	piR-hsa-7681	piR-hsa-7681	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-7681 may correlated with the increased risk of Alzheimer's disease.
PIRP00001426	25305452	DQ580466	piR-hsa-10692	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ580466 may correlated with the increased risk of Bladder carcinoma.
PIRP00001427	25305452	DQ570989	piR-hsa-1240	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ570989 may correlated with the increased risk of Bladder carcinoma.
PIRP00001428	28654860	piR-hsa-27271	piR-hsa-27271	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-27271 may correlated with the increased risk of Alzheimer's disease.
PIRP00001429	25305452	DQ582426	piR-hsa-12649	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ582426 may correlated with the increased risk of Bladder carcinoma.
PIRP00001430	22047710	piR-823	piR-hsa-1282	Gastric carcinoma	EFO:0000178	downregulation	increased risk	gastric cancer cells	N/A	N/A	Cell proliferation	-0.8	The piRNAs dysregulation associated with Gastric carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Gastric carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of piR-823 may correlated with the increased risk of Gastric carcinoma. Moreover, both molecular functions, physiological functions and/or mechanisms of piR-823 involving in the pathologies of Gastric carcinoma are illustrated in cell lines in vitro. Furthermore, the animal model experiments in vivo (eg. xenograft, transgenic) also demonstrated and supported the piR-823 dysregulation associated with the pathologies of Gastric carcinoma. Altogether, all above results suggested that the downregulation of piR-823 is possibly correlated with the increased risk of Gastric carcinoma.
PIRP00001430	24732595	piR-823	piR-hsa-1282	Multiple myeloma	EFO:0001378	upregulation	increased risk and poor progonosis	multiple myeloma patients and multiple myeloma cell lines	N/A	DNMT3A and 3B	Cell proliferation, cell apoptosis, cell cycle and angiogenesis	0.80	The piRNAs dysregulation associated with Multiple myeloma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Multiple myeloma was validated by RT-PCR. The validated results indicated that the upregulation of piR-823 may correlated with the increased risk and poor progonosis of Multiple myeloma. Moreover, both molecular functions, physiological functions and/or mechanisms of piR-823 involving in the pathologies of Multiple myeloma are illustrated in cell lines in vitro. Furthermore, the animal model experiments in vivo (eg. xenograft, transgenic) also demonstrated and supported the piR-823 dysregulation associated with the pathologies of Multiple myeloma. Altogether, all above results suggested that the upregulation of piR-823 is possibly correlated with the increased risk and poor progonosis of Multiple myeloma.
PIRP00001430	27414029	piR-823	piR-hsa-1282	Breast carcinoma	EFO:0000305	upregulation	poor progonosis	breast cancer cell line which was malignant	N/A	N/A	Cell proliferation and EMT signaling pathway	0.20	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-823 may correlated with the poor progonosis of Breast carcinoma. Moreover, the molecular functions or physiological functions of piR-823 involving in the pathologies of Breast carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-823 is possibly correlated with the poor progonosis of Breast carcinoma.
PIRP00001430	27414029	piR-823	piR-hsa-1282	Pancreatic carcinoma	EFO:0002618	upregulation	increased risk and poor progonosis	prostate cancer cell lines	N/A	mTOR	Cell proliferation and EMT signaling pathway	0.20	The piRNAs dysregulation associated with Pancreatic carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Pancreatic carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-823 may correlated with the increased risk and poor progonosis of Pancreatic carcinoma. Moreover, the molecular functions or physiological functions of piR-823 involving in the pathologies of Pancreatic carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-823 is possibly correlated with the increased risk and poor progonosis of Pancreatic carcinoma.
PIRP00001430	27429044	hsa_piR_000823	piR-hsa-1282	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_000823 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001430	27919963	piR-823	piR-hsa-1282	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	patientss with Renal Cell Carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-823 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001430	28618124	piR-823	piR-hsa-1282	Colorectal cancer	EFO:0005842	upregulation	increased risk	colorectal cancer patients and colorectal cancer cell lines	N/A	HSF1	Cell proliferation, cell death and apoptosis	0.60	The piRNAs dysregulation associated with Colorectal cancer was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Colorectal cancer was validated by RT-PCR. The validated results indicated that the upregulation of piR-823 may correlated with the increased risk of Colorectal cancer. Moreover, both molecular functions, physiological functions and mechanisms of piR-823 involving in the pathologies of Colorectal cancer are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-823 is possibly correlated with the increased risk of Colorectal cancer.
PIRP00001431	28654860	piR-hsa-28390	piR-hsa-28390	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-28390 may correlated with the increased risk of Alzheimer's disease.
PIRP00001432	28654860	piR-hsa-26156	piR-hsa-26156	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-26156 may correlated with the increased risk of Alzheimer's disease.
PIRP00001433	25305452	DQ570999	piR-hsa-1250	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ570999 may correlated with the increased risk of Bladder carcinoma.
PIRP00001434	27323410	piR-36716	piR-hsa-28850	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36716 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001434	27429044	hsa_piR_020814	piR-hsa-28850	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_020814 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001435	25305452	DQ600079	piR-hsa-30293	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ600079 may correlated with the increased risk of Bladder carcinoma.
PIRP00001436	25305452	DQ571000	piR-hsa-1251	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ571000 may correlated with the increased risk of Bladder carcinoma.
PIRP00001437	25305452	DQ577347	piR-hsa-7637	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ577347 may correlated with the increased risk of Bladder carcinoma.
PIRP00001438	28654860	piR-hsa-3645	piR-hsa-3645	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-3645 may correlated with the increased risk of Alzheimer's disease.
PIRP00001439	26205624	piR_011186	piR-hsa-15404	Leukemia	EFO:0000565	upregulation	increased risk	leukemia cell line U937	N/A	CDKN2B; DNMT1; Suv39H1;  EZH2	Cell cycle  and cell apoptosis	0.40	The piRNAs dysregulation associated with Leukemia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Leukemia was validated by RT-PCR. The validated results indicated that the upregulation of piR_011186 may correlated with the increased risk of Leukemia. Moreover, both molecular functions and physiological functions of piR_011186 involving in the pathologies of Leukemia are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR_011186 is possibly correlated with the increased risk of Leukemia.
PIRP00001440	25313140	DQ570994	piR-hsa-1245	Breast carcinoma	EFO:0000305	upregulation	increased risk	breast cancer	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of DQ570994 may correlated with the increased risk of Breast carcinoma.
PIRP00001441	23992744	piR-932	piR-hsa-1519	Breast carcinoma	EFO:0000305	upregulation	poor progonosis	breast cancer cell lines	N/A	N/A	EMT signaling pathway	0.20	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-932 may correlated with the poor progonosis of Breast carcinoma. Moreover, the molecular functions or physiological functions of piR-932 involving in the pathologies of Breast carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-932 is possibly correlated with the poor progonosis of Breast carcinoma.
PIRP00001442	25779046	pi-sno75	pi-sno75	Breast carcinoma	EFO:0000305	downregulation	increased risk	breast cancer cells	N/A	TRAIL	hCOMPASS-like complexes	-0.8	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of pi-sno75 may correlated with the increased risk of Breast carcinoma. Moreover, both molecular functions, physiological functions and/or mechanisms of pi-sno75 involving in the pathologies of Breast carcinoma are illustrated in cell lines in vitro. Furthermore, the animal model experiments in vivo (eg. xenograft, transgenic) also demonstrated and supported the pi-sno75 dysregulation associated with the pathologies of Breast carcinoma. Altogether, all above results suggested that the downregulation of pi-sno75 is possibly correlated with the increased risk of Breast carcinoma.
PIRP00001443	25305452	DQ570996	piR-hsa-1247	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ570996 may correlated with the increased risk of Bladder carcinoma.
PIRP00001444	25305452	DQ584144	piR-hsa-14366	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ584144 may correlated with the increased risk of Bladder carcinoma.
PIRP00001445	30555542	piR-54265	piR-hsa-17444	Colorectal adenocarcinoma	EFO:0000365	upregulation	increased risk	colorectal adenocarcinoma	N/A	PIWIL2	STAT3 signaling pathway, cell proliferation, metastasis and chemoresistance	0.80	The piRNAs dysregulation associated with Colorectal adenocarcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Colorectal adenocarcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-54265 may correlated with the increased risk of Colorectal adenocarcinoma. Moreover, both molecular functions, physiological functions and/or mechanisms of piR-54265 involving in the pathologies of Colorectal adenocarcinoma are illustrated in cell lines in vitro. Furthermore, the animal model experiments in vivo (eg. xenograft, transgenic) also demonstrated and supported the piR-54265 dysregulation associated with the pathologies of Colorectal adenocarcinoma. Altogether, all above results suggested that the upregulation of piR-54265 is possibly correlated with the increased risk of Colorectal adenocarcinoma.
PIRP00001446	27429044	hsa_piR_005076	piR-hsa-7327	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_005076 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001447	27323410	piR-36241	piR-hsa-28390	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36241 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001448	25305452	DQ593358	piR-hsa-23621	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ593358 may correlated with the increased risk of Bladder carcinoma.
PIRP00001449	25305452	DQ574993	piR-hsa-5299	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ574993 may correlated with the increased risk of Bladder carcinoma.
PIRP00001450	25305452	DQ597100	piR-hsa-27390	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ597100 may correlated with the increased risk of Bladder carcinoma.
PIRP00001451	25305452	DQ597101	piR-hsa-27391	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ597101 may correlated with the increased risk of Bladder carcinoma.
PIRP00001452	25305452	DQ596354	piR-hsa-26570	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596354 may correlated with the increased risk of Bladder carcinoma.
PIRP00001452	27429044	hsa_piR_019201	piR-hsa-26570	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_019201 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001452	27829231	DQ596354	piR-hsa-26570	Lung adenocarcinoma	EFO:0000571	upregulation	poor progonosis	lung adenocarcinoma samples	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Lung adenocarcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung adenocarcinoma was validated by RT-PCR. The validated results indicated that the upregulation of DQ596354 may correlated with the poor progonosis of Lung adenocarcinoma.
PIRP00001452	27829231	DQ596354	piR-hsa-26570	Squamous cell lung carcinoma	EFO:0000708	upregulation	poor progonosis	lung squamous cell carcinoma samples	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Squamous cell lung carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Squamous cell lung carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of DQ596354 may correlated with the poor progonosis of Squamous cell lung carcinoma.
PIRP00001453	27323410	piR-36245	piR-hsa-28394	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36245 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001453	28109471	piR-36245	piR-hsa-28394	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36245 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00001454	25305452	DQ589977	piR-hsa-20230	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ589977 may correlated with the increased risk of Bladder carcinoma.
PIRP00001455	25305452	DQ587714	piR-hsa-17990	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ587714 may correlated with the increased risk of Bladder carcinoma.
PIRP00001456	23229900	piR-20365	piR-hsa-28190	Breast carcinoma	EFO:0000305	upregulation	increased risk	resected breast cancer cases	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-20365 may correlated with the increased risk of Breast carcinoma.
PIRP00001457	27323410	piR-33043	piR-hsa-23209	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-33043 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001457	28109471	piR-33043	piR-hsa-23209	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-33043 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00001458	25305452	DQ596314	piR-hsa-26530	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596314 may correlated with the increased risk of Bladder carcinoma.
PIRP00001459	27323410	piR-36246	piR-hsa-28395	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36246 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001459	27429044	hsa_piR_020498	piR-hsa-28395	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_020498 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001460	25998508	piR-58594	piR-hsa-21746	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-58594 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001461	27323410	piR-36082	piR-hsa-28231	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36082 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001462	27323410	piR-31531	piR-hsa-1742	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-31531 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001463	28651359	DQ584698	piR-hsa-15023	Diminished ovarian reserve	EFO:0004770	upregulation	increased risk	patients with diminished ovarian reserve	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Diminished ovarian reserve was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ584698 may correlated with the increased risk of Diminished ovarian reserve.
PIRP00001464	25305452	DQ596356	piR-hsa-26572	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596356 may correlated with the increased risk of Bladder carcinoma.
PIRP00001465	27429044	hsa_piR_020657	piR-hsa-28629	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_020657 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001466	25998508	piR-58595	piR-hsa-21747	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-58595 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001467	25305452	DQ595212	piR-hsa-25473	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ595212 may correlated with the increased risk of Bladder carcinoma.
PIRP00001468	25305452	DQ598373	piR-hsa-28588	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ598373 may correlated with the increased risk of Bladder carcinoma.
PIRP00001469	25305452	DQ590020	piR-hsa-20273	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ590020 may correlated with the increased risk of Bladder carcinoma.
PIRP00001470	25305452	DQ594040	piR-hsa-24274	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ594040 may correlated with the increased risk of Bladder carcinoma.
PIRP00001470	25305452	DQ594040	piR-hsa-24274	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	TNFSF4	Cell proliferation and apoptosis 	-0.4	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Bladder carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of DQ594040 may correlated with the increased risk of Bladder carcinoma. Moreover, both molecular functions and physiological functions of DQ594040 involving in the pathologies of Bladder carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the downregulation of DQ594040 is possibly correlated with the increased risk of Bladder carcinoma.
PIRP00001471	25313140	DQ598252	piR-hsa-28467	Breast carcinoma	EFO:0000305	downregulation	increased risk	breast cancer	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of DQ598252 may correlated with the increased risk of Breast carcinoma.
PIRP00001472	25313140	DQ598183	piR-hsa-28398	Breast carcinoma	EFO:0000305	downregulation	increased risk	breast cancer	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of DQ598183 may correlated with the increased risk of Breast carcinoma.
PIRP00001472	27429044	hsa_piR_020499	piR-hsa-28398	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_020499 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001473	28654860	piR-hsa-226	piR-hsa-226	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-226 may correlated with the increased risk of Alzheimer's disease.
PIRP00001474	25305452	DQ598294	piR-hsa-28509	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ598294 may correlated with the increased risk of Bladder carcinoma.
PIRP00001475	25305452	DQ570392	piR-hsa-672	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ570392 may correlated with the increased risk of Bladder carcinoma.
PIRP00001476	27429044	hsa_piR_021190	piR-hsa-29417	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_021190 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001477	23112866	DQ589977	piR-hsa-20230	Sertoli cell-only syndrome	EFO:1001422	downregulation	increased risk	sertoli cell-only syndrome and spermatogenic failure patients	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Sertoli cell-only syndrome was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Sertoli cell-only syndrome was validated by RT-PCR. The validated results indicated that the downregulation of DQ589977 may correlated with the increased risk of Sertoli cell-only syndrome.
PIRP00001478	25998508	piR-32635	piR-hsa-12746	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-32635 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001479	27429044	hsa_piR_020450	piR-hsa-28319	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_020450 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001480	25305452	DQ570394	piR-hsa-674	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ570394 may correlated with the increased risk of Bladder carcinoma.
PIRP00001481	25998508	piR-32636	piR-hsa-12747	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-32636 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001482	25998508	piR-32637	piR-hsa-12748	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-32637 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001483	25305452	DQ597858	piR-hsa-28088	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ597858 may correlated with the increased risk of Bladder carcinoma.
PIRP00001484	26210741	piR-021285	piR-hsa-29509	Breast carcinoma	EFO:0000305	rs1326306	increased risk	breast cancer	N/A	N/A	Cell proliferation and EMT signaling pathway	-0.4	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the rs1326306 of piR-021285 may correlated with the increased risk of Breast carcinoma. Moreover, both molecular functions and physiological functions of piR-021285 involving in the pathologies of Breast carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the rs1326306 of piR-021285 is possibly correlated with the increased risk of Breast carcinoma.
PIRP00001485	25305452	DQ587024	piR-hsa-17330	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ587024 may correlated with the increased risk of Bladder carcinoma.
PIRP00001486	25305452	DQ579020	piR-hsa-9332	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ579020 may correlated with the increased risk of Bladder carcinoma.
PIRP00001487	27323410	piR-36041	piR-hsa-28190	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36041 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001488	26148798	DQ597484	piR-hsa-27730	Asthma	EFO:0000270	upregulation	increased risk	asthmatic patientss	N/A	N/A	Akt signaling pathway	0.10	The piRNAs dysregulation associated with Asthma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Asthma was validated by RT-PCR. The validated results indicated that the upregulation of DQ597484 may correlated with the increased risk of Asthma.
PIRP00001489	25305452	DQ579146	piR-hsa-9444	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ579146 may correlated with the increased risk of Bladder carcinoma.
PIRP00001490	28423657	piR-46545	piR-hsa-8674	Breast carcinoma	EFO:0000305	downregulation	increased risk	breast cancer cell lines	N/A	N/A	AMPK signaling pathway	-0.05	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-46545 may correlated with the increased risk of Breast carcinoma.
PIRP00001490	28423657	piR-46545	piR-hsa-8674	Lung carcinoma	EFO:0001071	downregulation	increased risk	lung cancer patients and lung cancer cell lines	N/A	AMPK	AMPK signaling pathway	-0.4	The piRNAs dysregulation associated with Lung carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of piR-46545 may correlated with the increased risk of Lung carcinoma. Moreover, both molecular functions and physiological functions of piR-46545 involving in the pathologies of Lung carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the downregulation of piR-46545 is possibly correlated with the increased risk of Lung carcinoma.
PIRP00001491	25305452	DQ574685	piR-hsa-5020	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ574685 may correlated with the increased risk of Bladder carcinoma.
PIRP00001492	27323410	piR-36318	piR-hsa-28467	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36318 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001493	25998508	piR-64616	piR-rno-50934	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-64616 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001494	25305452	DQ582571	piR-hsa-12794	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ582571 may correlated with the increased risk of Bladder carcinoma.
PIRP00001495	28654860	piR-hsa-4685	piR-hsa-4685	Alzheimer's disease	EFO:0000249	downregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-hsa-4685 may correlated with the increased risk of Alzheimer's disease.
PIRP00001496	27829231	DQ596354	piR-hsa-26570	Lung adenocarcinoma	EFO:0000571	upregulation	poor progonosis	lung adenocarcinoma samples	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Lung adenocarcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung adenocarcinoma was validated by RT-PCR. The validated results indicated that the upregulation of DQ596354 may correlated with the poor progonosis of Lung adenocarcinoma.
PIRP00001497	25305452	DQ580256	piR-hsa-10496	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ580256 may correlated with the increased risk of Bladder carcinoma.
PIRP00001498	24732595	piR-823	piR-hsa-1282	Multiple myeloma	EFO:0001378	upregulation	increased risk and poor progonosis	multiple myeloma patients and multiple myeloma cell lines	N/A	DNMT3A and 3B	Cell proliferation, cell apoptosis, cell cycle and angiogenesis	0.80	The piRNAs dysregulation associated with Multiple myeloma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Multiple myeloma was validated by RT-PCR. The validated results indicated that the upregulation of piR-823 may correlated with the increased risk and poor progonosis of Multiple myeloma. Moreover, both molecular functions, physiological functions and/or mechanisms of piR-823 involving in the pathologies of Multiple myeloma are illustrated in cell lines in vitro. Furthermore, the animal model experiments in vivo (eg. xenograft, transgenic) also demonstrated and supported the piR-823 dysregulation associated with the pathologies of Multiple myeloma. Altogether, all above results suggested that the upregulation of piR-823 is possibly correlated with the increased risk and poor progonosis of Multiple myeloma.
PIRP00001499	25305452	DQ574835	piR-hsa-5170	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ574835 may correlated with the increased risk of Bladder carcinoma.
PIRP00001500	25998508	piR-39894	piR-hsa-32052	Renal cell carcinoma	EFO:0000681	upregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	0.20	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Renal cell carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-39894 may correlated with the increased risk and poor progonosis of Renal cell carcinoma. Moreover, the molecular functions or physiological functions of piR-39894 involving in the pathologies of Renal cell carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-39894 is possibly correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001501	27429044	hsa_piR_009051	piR-hsa-12487	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_009051 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001502	25910082	piR-017061	piR-hsa-23822	Pancreatic carcinoma	EFO:0002618	downregulation	increased risk	pancreatic cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Pancreatic carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-017061 may correlated with the increased risk of Pancreatic carcinoma.
PIRP00001502	27429044	hsa_piR_017061	piR-hsa-23822	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_017061 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001503	28654860	piR-hsa-28771	piR-hsa-28771	Alzheimer's disease	EFO:0000249	downregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-hsa-28771 may correlated with the increased risk of Alzheimer's disease.
PIRP00001504	27323410	piR-30840	piR-hsa-993	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-30840 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001505	26148798	DQ582264	piR-hsa-12487	Asthma	EFO:0000270	upregulation	increased risk	asthmatic patientss	N/A	N/A	Akt signaling pathway	0.10	The piRNAs dysregulation associated with Asthma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Asthma was validated by RT-PCR. The validated results indicated that the upregulation of DQ582264 may correlated with the increased risk of Asthma.
PIRP00001506	25305452	DQ593618	piR-hsa-23866	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ593618 may correlated with the increased risk of Bladder carcinoma.
PIRP00001507	25998508	piR-32051	piR-hsa-12178	Renal cell carcinoma	EFO:0000681	upregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	0.20	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Renal cell carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-32051 may correlated with the increased risk and poor progonosis of Renal cell carcinoma. Moreover, the molecular functions or physiological functions of piR-32051 involving in the pathologies of Renal cell carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-32051 is possibly correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001508	25305452	DQ595212	piR-hsa-25473	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ595212 may correlated with the increased risk of Bladder carcinoma.
PIRP00001509	26210741	piR-021285	piR-hsa-29509	Breast carcinoma	EFO:0000305	rs1326306	increased risk	breast cancer	N/A	N/A	Cell proliferation and EMT signaling pathway	-0.4	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the rs1326306 of piR-021285 may correlated with the increased risk of Breast carcinoma. Moreover, both molecular functions and physiological functions of piR-021285 involving in the pathologies of Breast carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the rs1326306 of piR-021285 is possibly correlated with the increased risk of Breast carcinoma.
PIRP00001510	25305452	DQ593621	piR-hsa-23869	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ593621 may correlated with the increased risk of Bladder carcinoma.
PIRP00001511	25305452	DQ591874	piR-hsa-22122	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ591874 may correlated with the increased risk of Bladder carcinoma.
PIRP00001512	29382334	piR-26525	piR-26525	Colorectal cancer	EFO:0005842	downregulation	increased risk and poor progonosis	colorectal cancer patients	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Colorectal cancer was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Colorectal cancer was validated by RT-PCR. The validated results indicated that the downregulation of piR-26525 may correlated with the increased risk and poor progonosis of Colorectal cancer.
PIRP00001513	25305452	DQ577614	piR-hsa-6917	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ577614 may correlated with the increased risk of Bladder carcinoma.
PIRP00001514	25305452	DQ596932	piR-hsa-27222	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ596932 may correlated with the increased risk of Bladder carcinoma.
PIRP00001515	28651359	DQ591357	piR-hsa-21622	Diminished ovarian reserve	EFO:0004770	upregulation	increased risk	patients with diminished ovarian reserve	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Diminished ovarian reserve was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ591357 may correlated with the increased risk of Diminished ovarian reserve.
PIRP00001516	27323410	piR-30229	piR-hsa-426	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-30229 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001516	28109471	piR-30229	piR-hsa-426	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-30229 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00001517	29382334	piR-26525	piR-26525	Colorectal cancer	EFO:0005842	downregulation	increased risk and poor progonosis	colorectal cancer patients	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Colorectal cancer was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Colorectal cancer was validated by RT-PCR. The validated results indicated that the downregulation of piR-26525 may correlated with the increased risk and poor progonosis of Colorectal cancer.
PIRP00001518	27323410	piR-41794	piR-hsa-3961	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-41794 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001519	25305452	DQ597858	piR-hsa-28088	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ597858 may correlated with the increased risk of Bladder carcinoma.
PIRP00001520	25305452	DQ589802	piR-hsa-20070	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ589802 may correlated with the increased risk of Bladder carcinoma.
PIRP00001521	28651359	DQ579193	piR-hsa-9491	Diminished ovarian reserve	EFO:0004770	upregulation	increased risk	patients with diminished ovarian reserve	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Diminished ovarian reserve was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ579193 may correlated with the increased risk of Diminished ovarian reserve.
PIRP00001522	21616063	piR-651	piR-hsa-1077	Colon carcinoma	EFO:1001950	upregulation	increased risk	colon cancer tissues	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Colon carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Colon carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-651 may correlated with the increased risk of Colon carcinoma.
PIRP00001523	25305452	DQ582387	piR-hsa-12610	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ582387 may correlated with the increased risk of Bladder carcinoma.
PIRP00001524	25305452	DQ581440	piR-hsa-11725	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ581440 may correlated with the increased risk of Bladder carcinoma.
PIRP00001525	25305452	DQ576844	piR-hsa-7180	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ576844 may correlated with the increased risk of Bladder carcinoma.
PIRP00001526	25305452	DQ579049	piR-hsa-9361	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ579049 may correlated with the increased risk of Bladder carcinoma.
PIRP00001527	27323410	piR-33510	piR-hsa-22905	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-33510 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001528	28654860	piR-hsa-28116	piR-hsa-28116	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-28116 may correlated with the increased risk of Alzheimer's disease.
PIRP00001529	25305452	DQ601506	piR-hsa-31746	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ601506 may correlated with the increased risk of Bladder carcinoma.
PIRP00001530	25305452	DQ596690	piR-hsa-26892	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ596690 may correlated with the increased risk of Bladder carcinoma.
PIRP00001531	25305452	DQ601548	piR-hsa-31788	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ601548 may correlated with the increased risk of Bladder carcinoma.
PIRP00001532	25305452	DQ600174	piR-hsa-30374	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ600174 may correlated with the increased risk of Bladder carcinoma.
PIRP00001533	26408181	piR-55490	piR-hsa-9	Lung carcinoma	EFO:0001071	downregulation	increased risk	lung cancer cells	N/A	mTOR	Akt/mTOR signaling pathway	-0.8	The piRNAs dysregulation associated with Lung carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of piR-55490 may correlated with the increased risk of Lung carcinoma. Moreover, both molecular functions, physiological functions and/or mechanisms of piR-55490 involving in the pathologies of Lung carcinoma are illustrated in cell lines in vitro. Furthermore, the animal model experiments in vivo (eg. xenograft, transgenic) also demonstrated and supported the piR-55490 dysregulation associated with the pathologies of Lung carcinoma. Altogether, all above results suggested that the downregulation of piR-55490 is possibly correlated with the increased risk of Lung carcinoma.
PIRP00001534	25305452	DQ574109	piR-hsa-4371	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ574109 may correlated with the increased risk of Bladder carcinoma.
PIRP00001535	25305452	DQ600079	piR-hsa-30293	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ600079 may correlated with the increased risk of Bladder carcinoma.
PIRP00001536	27429044	hsa_piR_000291	piR-hsa-624	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_000291 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001537	27323410	piR-54265	piR-hsa-17444	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-54265 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001537	27429044	hsa_piR_012681	piR-hsa-17444	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_012681 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001537	30555542	piR-54265	piR-hsa-17444	Colorectal adenocarcinoma	EFO:0000365	upregulation	increased risk	colorectal adenocarcinoma	N/A	PIWIL2	STAT3 signaling pathway, cell proliferation, metastasis and chemoresistance	0.80	The piRNAs dysregulation associated with Colorectal adenocarcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Colorectal adenocarcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-54265 may correlated with the increased risk of Colorectal adenocarcinoma. Moreover, both molecular functions, physiological functions and/or mechanisms of piR-54265 involving in the pathologies of Colorectal adenocarcinoma are illustrated in cell lines in vitro. Furthermore, the animal model experiments in vivo (eg. xenograft, transgenic) also demonstrated and supported the piR-54265 dysregulation associated with the pathologies of Colorectal adenocarcinoma. Altogether, all above results suggested that the upregulation of piR-54265 is possibly correlated with the increased risk of Colorectal adenocarcinoma.
PIRP00001538	25305452	DQ601166	piR-hsa-31436	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ601166 may correlated with the increased risk of Bladder carcinoma.
PIRP00001539	25305452	DQ598641	piR-hsa-28841	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ598641 may correlated with the increased risk of Bladder carcinoma.
PIRP00001540	25305452	DQ580653	piR-hsa-10879	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ580653 may correlated with the increased risk of Bladder carcinoma.
PIRP00001541	25998508	piR-34434	piR-hsa-26584	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-34434 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001542	28654860	piR-hsa-9378	piR-hsa-9378	Alzheimer's disease	EFO:0000249	downregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-hsa-9378 may correlated with the increased risk of Alzheimer's disease.
PIRP00001543	27429044	hsa_piR_011901	piR-hsa-16348	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_011901 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001544	25305452	DQ593358	piR-hsa-23621	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ593358 may correlated with the increased risk of Bladder carcinoma.
PIRP00001544	27429044	hsa_piR_016946	piR-hsa-23621	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_016946 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001545	25305452	DQ587101	piR-hsa-17407	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ587101 may correlated with the increased risk of Bladder carcinoma.
PIRP00001546	27429044	hsa_piR_019914	piR-hsa-27622	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_019914 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001547	27429044	hsa_piR_019368	piR-hsa-26819	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_019368 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001548	27429044	hsa_piR_016975	piR-hsa-23663	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_016975 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001549	26265322	piR-006113	piR-hsa-8632	Testicular germ cell tumor	EFO:1000566	downregulation	increased risk	testicular germ cell tumors	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Testicular germ cell tumor was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Testicular germ cell tumor was validated by RT-PCR. The validated results indicated that the downregulation of piR-006113 may correlated with the increased risk of Testicular germ cell tumor.
PIRP00001550	27323410	piR-36711	piR-hsa-28845	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-36711 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001551	25305452	DQ597100	piR-hsa-27390	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ597100 may correlated with the increased risk of Bladder carcinoma.
PIRP00001552	28654860	piR-hsa-18061	piR-hsa-18061	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-18061 may correlated with the increased risk of Alzheimer's disease.
PIRP00001553	27323410	piR-36712	piR-hsa-28846	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-36712 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001554	25305452	DQ597101	piR-hsa-27391	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ597101 may correlated with the increased risk of Bladder carcinoma.
PIRP00001555	27323410	piR-36713	piR-hsa-28847	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36713 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001556	28423657	piR-35127	piR-hsa-27351	Breast carcinoma	EFO:0000305	downregulation	increased risk	breast cancer cell lines	N/A	N/A	AMPK signaling pathway	-0.05	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-35127 may correlated with the increased risk of Breast carcinoma.
PIRP00001556	28423657	piR-35127	piR-hsa-27351	Lung carcinoma	EFO:0001071	downregulation	increased risk	lung cancer patients and lung cancer cell lines	N/A	AMPK	AMPK signaling pathway	-0.4	The piRNAs dysregulation associated with Lung carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of piR-35127 may correlated with the increased risk of Lung carcinoma. Moreover, both molecular functions and physiological functions of piR-35127 involving in the pathologies of Lung carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the downregulation of piR-35127 is possibly correlated with the increased risk of Lung carcinoma.
PIRP00001557	27323410	piR-36714	piR-hsa-28848	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36714 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001558	27323410	piR-36715	piR-hsa-28849	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36715 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001559	25305452	DQ590027	piR-hsa-20280	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ590027 may correlated with the increased risk of Bladder carcinoma.
PIRP00001560	25305452	DQ590028	piR-hsa-20281	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ590028 may correlated with the increased risk of Bladder carcinoma.
PIRP00001561	25305452	DQ585585	piR-hsa-15880	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ585585 may correlated with the increased risk of Bladder carcinoma.
PIRP00001562	25305452	DQ590029	piR-hsa-20282	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ590029 may correlated with the increased risk of Bladder carcinoma.
PIRP00001563	27323410	piR-36074	piR-hsa-28223	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-36074 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001564	27323410	piR-35221	piR-hsa-27124	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-35221 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001565	25305452	DQ590030	piR-hsa-20283	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ590030 may correlated with the increased risk of Bladder carcinoma.
PIRP00001566	25305452	DQ591874	piR-hsa-22122	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ591874 may correlated with the increased risk of Bladder carcinoma.
PIRP00001567	25305452	DQ591351	piR-hsa-21616	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ591351 may correlated with the increased risk of Bladder carcinoma.
PIRP00001568	25305452	DQ590031	piR-hsa-20284	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ590031 may correlated with the increased risk of Bladder carcinoma.
PIRP00001569	25305452	DQ590335	piR-hsa-20559	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ590335 may correlated with the increased risk of Bladder carcinoma.
PIRP00001570	28654860	piR-hsa-30217	piR-hsa-30217	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-30217 may correlated with the increased risk of Alzheimer's disease.
PIRP00001571	25305452	DQ575340	piR-hsa-5632	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ575340 may correlated with the increased risk of Bladder carcinoma.
PIRP00001572	25305452	DQ585261	piR-hsa-15572	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ585261 may correlated with the increased risk of Bladder carcinoma.
PIRP00001573	27323410	piR-33534	piR-hsa-23670	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-33534 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001574	28654860	piR-hsa-29114	piR-hsa-29114	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-29114 may correlated with the increased risk of Alzheimer's disease.
PIRP00001575	28423657	piR-34871	piR-hsa-27007	Breast carcinoma	EFO:0000305	upregulation	increased risk	breast cancer cell lines	N/A	N/A	AMPK signaling pathway	0.05	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-34871 may correlated with the increased risk of Breast carcinoma.
PIRP00001575	28423657	piR-34871	piR-hsa-27007	Lung carcinoma	EFO:0001071	upregulation	increased risk	lung cancer patients and lung cancer cell lines	N/A	AMPK	AMPK signaling pathway	0.40	The piRNAs dysregulation associated with Lung carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-34871 may correlated with the increased risk of Lung carcinoma. Moreover, both molecular functions and physiological functions of piR-34871 involving in the pathologies of Lung carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-34871 is possibly correlated with the increased risk of Lung carcinoma.
PIRP00001576	25998508	piR-57849	piR-hsa-21033	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-57849 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001577	25305452	DQ582387	piR-hsa-12610	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ582387 may correlated with the increased risk of Bladder carcinoma.
PIRP00001578	28654860	piR-hsa-19953	piR-hsa-19953	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-19953 may correlated with the increased risk of Alzheimer's disease.
PIRP00001579	25305452	DQ579049	piR-hsa-9361	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ579049 may correlated with the increased risk of Bladder carcinoma.
PIRP00001580	27429044	hsa_piR_003728	piR-hsa-5370	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_003728 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001581	25998508	piR-54436	piR-hsa-17615	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-54436 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001582	23112866	DQ601291	piR-hsa-31561	Sertoli cell-only syndrome	EFO:1001422	downregulation	increased risk	sertoli cell-only syndrome and spermatogenic failure patients	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Sertoli cell-only syndrome was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Sertoli cell-only syndrome was validated by RT-PCR. The validated results indicated that the downregulation of DQ601291 may correlated with the increased risk of Sertoli cell-only syndrome.
PIRP00001583	25305452	DQ571328	piR-hsa-1331	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ571328 may correlated with the increased risk of Bladder carcinoma.
PIRP00001584	25305452	DQ600174	piR-hsa-30374	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ600174 may correlated with the increased risk of Bladder carcinoma.
PIRP00001585	28654860	piR-hsa-30713	piR-hsa-30713	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-30713 may correlated with the increased risk of Alzheimer's disease.
PIRP00001586	25305452	DQ586998	piR-hsa-17304	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ586998 may correlated with the increased risk of Bladder carcinoma.
PIRP00001587	28654860	piR-hsa-27398	piR-hsa-27398	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-27398 may correlated with the increased risk of Alzheimer's disease.
PIRP00001588	28654860	piR-hsa-20749	piR-hsa-20749	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-20749 may correlated with the increased risk of Alzheimer's disease.
PIRP00001589	28654860	piR-hsa-27399	piR-hsa-27399	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-27399 may correlated with the increased risk of Alzheimer's disease.
PIRP00001590	25305452	DQ574685	piR-hsa-5020	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ574685 may correlated with the increased risk of Bladder carcinoma.
PIRP00001591	27197292	piR-18913	piR-hsa-26213	Glioma	EFO:0005543	rs62435800	decreased risk	glioma cell	N/A	N/A	N/A	0.20	The piRNAs dysregulation associated with Glioma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Glioma was validated by RT-PCR. The validated results indicated that the rs62435800 of piR-18913 may correlated with the decreased risk of Glioma. Moreover, the molecular functions or physiological functions of piR-18913 involving in the pathologies of Glioma are illustrated in cell lines in vitro. Altogether, all above results suggested that the rs62435800 of piR-18913 is possibly correlated with the decreased risk of Glioma.
PIRP00001592	27429044	hsa_piR_001042	piR-hsa-1338	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_001042 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001593	27323410	piR-36241	piR-hsa-28390	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36241 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001594	25305452	DQ590455	piR-hsa-20664	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ590455 may correlated with the increased risk of Bladder carcinoma.
PIRP00001595	25305452	DQ593538	piR-hsa-23786	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ593538 may correlated with the increased risk of Bladder carcinoma.
PIRP00001596	28654860	piR-hsa-14962	piR-hsa-14962	Alzheimer's disease	EFO:0000249	downregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-hsa-14962 may correlated with the increased risk of Alzheimer's disease.
PIRP00001597	26095918	piR-L-163	piR-L-163	Non-small cell lung carcinoma	EFO:0003060	downregulation	increased risk and poor progonosis	non-small cell lung cancer (NSCLC) cell lines	N/A	p-ERM	Cell cycle  and cell migration and cell invasion	-0.6	The piRNAs dysregulation associated with Non-small cell lung carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Non-small cell lung carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of piR-L-163 may correlated with the increased risk and poor progonosis of Non-small cell lung carcinoma. Moreover, both molecular functions, physiological functions and mechanisms of piR-L-163 involving in the pathologies of Non-small cell lung carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the downregulation of piR-L-163 is possibly correlated with the increased risk and poor progonosis of Non-small cell lung carcinoma.
PIRP00001598	25305452	DQ572870	piR-hsa-3178	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ572870 may correlated with the increased risk of Bladder carcinoma.
PIRP00001599	25779424	FR064000	FR064000	Gastric carcinoma	EFO:0000178	upregulation	poor progonosis	gastric cancer recurrence	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Gastric carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of FR064000 may correlated with the poor progonosis of Gastric carcinoma.
PIRP00001600	25305452	DQ598548	piR-hsa-28749	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ598548 may correlated with the increased risk of Bladder carcinoma.
PIRP00001601	25305452	DQ580927	piR-hsa-11256	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ580927 may correlated with the increased risk of Bladder carcinoma.
PIRP00001601	27429044	hsa_piR_008033	piR-hsa-11256	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_008033 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001602	25305452	DQ595292	piR-hsa-25553	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ595292 may correlated with the increased risk of Bladder carcinoma.
PIRP00001603	27323410	piR-36245	piR-hsa-28394	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36245 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001603	28109471	piR-36245	piR-hsa-28394	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36245 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00001604	26148798	DQ595186	piR-hsa-25447	Asthma	EFO:0000270	upregulation	increased risk	asthmatic patientss	N/A	N/A	Akt signaling pathway	0.10	The piRNAs dysregulation associated with Asthma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Asthma was validated by RT-PCR. The validated results indicated that the upregulation of DQ595186 may correlated with the increased risk of Asthma.
PIRP00001605	28654860	piR-hsa-24169	piR-hsa-24169	Alzheimer's disease	EFO:0000249	downregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-hsa-24169 may correlated with the increased risk of Alzheimer's disease.
PIRP00001606	27323410	piR-36716	piR-hsa-28850	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36716 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001607	27323410	piR-36246	piR-hsa-28395	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36246 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001607	27429044	hsa_piR_020498	piR-hsa-28395	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_020498 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001608	25998508	piR-58594	piR-hsa-21746	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-58594 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001609	27429044	hsa_piR_020657	piR-hsa-28629	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_020657 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001610	25998508	piR-58595	piR-hsa-21747	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-58595 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001611	27429044	hsa_piR_019102	piR-hsa-26441	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_019102 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001612	25305452	DQ584635	piR-hsa-14960	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ584635 may correlated with the increased risk of Bladder carcinoma.
PIRP00001613	25305452	DQ590027	piR-hsa-20280	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ590027 may correlated with the increased risk of Bladder carcinoma.
PIRP00001614	27429044	hsa_piR_016240	piR-hsa-22382	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_016240 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001615	25998508	piR-54542	piR-hsa-17720	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-54542 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001616	25313140	DQ598183	piR-hsa-28398	Breast carcinoma	EFO:0000305	downregulation	increased risk	breast cancer	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of DQ598183 may correlated with the increased risk of Breast carcinoma.
PIRP00001616	27429044	hsa_piR_020499	piR-hsa-28398	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_020499 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001617	25305452	DQ590028	piR-hsa-20281	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ590028 may correlated with the increased risk of Bladder carcinoma.
PIRP00001618	25305452	DQ590029	piR-hsa-20282	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ590029 may correlated with the increased risk of Bladder carcinoma.
PIRP00001619	28651359	DQ597348	piR-hsa-27623	Diminished ovarian reserve	EFO:0004770	upregulation	increased risk	patients with diminished ovarian reserve	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Diminished ovarian reserve was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Diminished ovarian reserve was validated by RT-PCR. The validated results indicated that the upregulation of DQ597348 may correlated with the increased risk of Diminished ovarian reserve.
PIRP00001620	25305452	DQ596111	piR-hsa-26343	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596111 may correlated with the increased risk of Bladder carcinoma.
PIRP00001621	25305452	DQ590030	piR-hsa-20283	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ590030 may correlated with the increased risk of Bladder carcinoma.
PIRP00001622	25305452	DQ591007	piR-hsa-21286	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ591007 may correlated with the increased risk of Bladder carcinoma.
PIRP00001623	27429044	hsa_piR_020450	piR-hsa-28319	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_020450 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001624	25305452	DQ590031	piR-hsa-20284	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ590031 may correlated with the increased risk of Bladder carcinoma.
PIRP00001625	28654860	piR-hsa-27271	piR-hsa-27271	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-27271 may correlated with the increased risk of Alzheimer's disease.
PIRP00001626	25305452	DQ575105	piR-hsa-5411	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ575105 may correlated with the increased risk of Bladder carcinoma.
PIRP00001627	25305452	DQ590335	piR-hsa-20559	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ590335 may correlated with the increased risk of Bladder carcinoma.
PIRP00001628	25305452	DQ597858	piR-hsa-28088	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ597858 may correlated with the increased risk of Bladder carcinoma.
PIRP00001629	27323410	piR-36082	piR-hsa-28231	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36082 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001630	25998508	piR-43147	piR-hsa-5341	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-43147 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001631	25305452	DQ577614	piR-hsa-6917	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ577614 may correlated with the increased risk of Bladder carcinoma.
PIRP00001632	25305452	DQ581488	piR-hsa-11773	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ581488 may correlated with the increased risk of Bladder carcinoma.
PIRP00001633	25305452	DQ572042	piR-hsa-2322	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ572042 may correlated with the increased risk of Bladder carcinoma.
PIRP00001634	27323410	piR-60238	piR-hsa-24360	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-60238 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001635	25305452	DQ600310	piR-hsa-30510	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ600310 may correlated with the increased risk of Bladder carcinoma.
PIRP00001636	25305452	DQ572051	piR-hsa-2331	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ572051 may correlated with the increased risk of Bladder carcinoma.
PIRP00001637	27323410	piR-61919	piR-hsa-26039	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-61919 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001638	28460486	piR-57125	piR-hsa-20266	Lung adenocarcinoma	EFO:0000571	downregulation	poor progonosis	lung adenocarcinoma	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Lung adenocarcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung adenocarcinoma was validated by RT-PCR. The validated results indicated that the downregulation of piR-57125 may correlated with the poor progonosis of Lung adenocarcinoma.
PIRP00001639	27323410	piR-54907	piR-hsa-18071	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-54907 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001640	26205624	piR_011186	piR-hsa-15404	Leukemia	EFO:0000565	upregulation	increased risk	leukemia cell line U937	N/A	CDKN2B; DNMT1; Suv39H1;  EZH2	Cell cycle  and cell apoptosis	0.40	The piRNAs dysregulation associated with Leukemia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Leukemia was validated by RT-PCR. The validated results indicated that the upregulation of piR_011186 may correlated with the increased risk of Leukemia. Moreover, both molecular functions and physiological functions of piR_011186 involving in the pathologies of Leukemia are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR_011186 is possibly correlated with the increased risk of Leukemia.
PIRP00001640	29516567	piR-52205	piR-hsa-15404	Neuroblastoma	EFO:0000621	upregulation	increased risk	neuroblastoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Neuroblastoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-52205 may correlated with the increased risk of Neuroblastoma.
PIRP00001641	25305452	DQ575775	piR-hsa-6053	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ575775 may correlated with the increased risk of Bladder carcinoma.
PIRP00001642	28654860	piR-hsa-29476	piR-hsa-29476	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-29476 may correlated with the increased risk of Alzheimer's disease.
PIRP00001643	28651359	DQ596805	piR-hsa-27007	Diminished ovarian reserve	EFO:0004770	upregulation	increased risk	patients with diminished ovarian reserve	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Diminished ovarian reserve was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Diminished ovarian reserve was validated by RT-PCR. The validated results indicated that the upregulation of DQ596805 may correlated with the increased risk of Diminished ovarian reserve.
PIRP00001644	29516567	piR-52206	piR-hsa-15405	Neuroblastoma	EFO:0000621	upregulation	increased risk	neuroblastoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Neuroblastoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-52206 may correlated with the increased risk of Neuroblastoma.
PIRP00001645	25305452	DQ589164	piR-hsa-19446	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ589164 may correlated with the increased risk of Bladder carcinoma.
PIRP00001646	25305452	DQ570999	piR-hsa-1250	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ570999 may correlated with the increased risk of Bladder carcinoma.
PIRP00001647	25305452	DQ586998	piR-hsa-17304	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ586998 may correlated with the increased risk of Bladder carcinoma.
PIRP00001648	25305452	DQ596660	piR-hsa-26862	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596660 may correlated with the increased risk of Bladder carcinoma.
PIRP00001649	25305452	DQ581096	piR-hsa-11425	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ581096 may correlated with the increased risk of Bladder carcinoma.
PIRP00001650	25305452	DQ571000	piR-hsa-1251	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ571000 may correlated with the increased risk of Bladder carcinoma.
PIRP00001651	28654860	piR-hsa-29478	piR-hsa-29478	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-29478 may correlated with the increased risk of Alzheimer's disease.
PIRP00001652	26071182	piR-30924	piR-hsa-1077	Clear cell renal cell carcinomas	EFO:0000349	upregulation	poor progonosis	clear cell renal cell carcinomas patients	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Clear cell renal cell carcinomas was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Clear cell renal cell carcinomas was validated by RT-PCR. The validated results indicated that the upregulation of piR-30924 may correlated with the poor progonosis of Clear cell renal cell carcinomas.
PIRP00001653	27323410	piR-34440	piR-hsa-26590	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-34440 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001654	26071182	piR-38756	piR-hsa-30978	Clear cell renal cell carcinomas	EFO:0000349	upregulation	poor progonosis	clear cell renal cell carcinomas patients	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Clear cell renal cell carcinomas was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Clear cell renal cell carcinomas was validated by RT-PCR. The validated results indicated that the upregulation of piR-38756 may correlated with the poor progonosis of Clear cell renal cell carcinomas.
PIRP00001655	27323410	piR-33534	piR-hsa-23670	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-33534 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001656	25305452	DQ572870	piR-hsa-3178	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ572870 may correlated with the increased risk of Bladder carcinoma.
PIRP00001657	27323410	piR-33880	piR-hsa-24016	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-33880 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001658	25305452	DQ597696	piR-hsa-27926	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ597696 may correlated with the increased risk of Bladder carcinoma.
PIRP00001659	25305452	DQ599994	piR-hsa-30208	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ599994 may correlated with the increased risk of Bladder carcinoma.
PIRP00001660	25305452	DQ593739	piR-hsa-23987	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ593739 may correlated with the increased risk of Bladder carcinoma.
PIRP00001661	25305452	DQ574993	piR-hsa-5299	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ574993 may correlated with the increased risk of Bladder carcinoma.
PIRP00001662	27429044	hsa_piR_018165	piR-hsa-25313	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_018165 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001663	25305452	DQ598548	piR-hsa-28749	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ598548 may correlated with the increased risk of Bladder carcinoma.
PIRP00001664	25305452	DQ595292	piR-hsa-25553	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ595292 may correlated with the increased risk of Bladder carcinoma.
PIRP00001665	27323410	piR-35855	piR-hsa-28019	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-35855 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001666	27429044	hsa_piR_005076	piR-hsa-7327	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_005076 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001667	25998508	piR-36318	piR-hsa-28467	Renal cell carcinoma	EFO:0000681	upregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36318 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001668	27429044	hsa_piR_016970	piR-hsa-23655	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_016970 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001669	25305452	DQ596300	piR-hsa-26516	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596300 may correlated with the increased risk of Bladder carcinoma.
PIRP00001670	25313140	DQ597341	piR-hsa-27616	Breast carcinoma	EFO:0000305	downregulation	increased risk	breast cancer	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of DQ597341 may correlated with the increased risk of Breast carcinoma.
PIRP00001671	25305452	DQ594556	piR-hsa-24775	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ594556 may correlated with the increased risk of Bladder carcinoma.
PIRP00001671	27429044	hsa_piR_017791	piR-hsa-24775	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_017791 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001672	25305452	DQ585585	piR-hsa-15880	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ585585 may correlated with the increased risk of Bladder carcinoma.
PIRP00001673	25305452	DQ584635	piR-hsa-14960	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ584635 may correlated with the increased risk of Bladder carcinoma.
PIRP00001674	25305452	DQ593354	piR-hsa-23617	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ593354 may correlated with the increased risk of Bladder carcinoma.
PIRP00001675	25305452	DQ591874	piR-hsa-22122	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ591874 may correlated with the increased risk of Bladder carcinoma.
PIRP00001676	28654860	piR-hsa-20271	piR-hsa-20271	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-20271 may correlated with the increased risk of Alzheimer's disease.
PIRP00001677	25305452	DQ593431	piR-hsa-23679	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ593431 may correlated with the increased risk of Bladder carcinoma.
PIRP00001678	25305452	DQ591007	piR-hsa-21286	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ591007 may correlated with the increased risk of Bladder carcinoma.
PIRP00001679	28423657	piR-46545	piR-hsa-8674	Lung carcinoma	EFO:0001071	downregulation	increased risk	lung cancer patients and lung cancer cell lines	N/A	AMPK	AMPK signaling pathway	-0.4	The piRNAs dysregulation associated with Lung carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of piR-46545 may correlated with the increased risk of Lung carcinoma. Moreover, both molecular functions and physiological functions of piR-46545 involving in the pathologies of Lung carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the downregulation of piR-46545 is possibly correlated with the increased risk of Lung carcinoma.
PIRP00001680	25998508	piR-45808	piR-hsa-7955	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-45808 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001681	25998508	piR-45809	piR-hsa-7956	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-45809 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001682	25305452	DQ580466	piR-hsa-10692	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ580466 may correlated with the increased risk of Bladder carcinoma.
PIRP00001683	25305452	DQ585261	piR-hsa-15572	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ585261 may correlated with the increased risk of Bladder carcinoma.
PIRP00001684	25305452	DQ577740	piR-hsa-7999	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ577740 may correlated with the increased risk of Bladder carcinoma.
PIRP00001685	25305452	DQ576153	piR-hsa-6416	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ576153 may correlated with the increased risk of Bladder carcinoma.
PIRP00001686	25305452	DQ576939	piR-hsa-7260	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ576939 may correlated with the increased risk of Bladder carcinoma.
PIRP00001687	25305452	DQ577347	piR-hsa-7637	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ577347 may correlated with the increased risk of Bladder carcinoma.
PIRP00001688	25305452	DQ581488	piR-hsa-11773	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ581488 may correlated with the increased risk of Bladder carcinoma.
PIRP00001689	26265322	piR-007509	piR-hsa-10476	Testicular germ cell tumor	EFO:1000566	downregulation	increased risk	testicular germ cell tumors	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Testicular germ cell tumor was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Testicular germ cell tumor was validated by RT-PCR. The validated results indicated that the downregulation of piR-007509 may correlated with the increased risk of Testicular germ cell tumor.
PIRP00001690	27323410	piR-39307	piR-hsa-31511	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-39307 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001691	28651359	DQ598104	piR-hsa-28319	Diminished ovarian reserve	EFO:0004770	upregulation	increased risk	patients with diminished ovarian reserve	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Diminished ovarian reserve was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ598104 may correlated with the increased risk of Diminished ovarian reserve.
PIRP00001692	25305452	DQ579146	piR-hsa-9444	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ579146 may correlated with the increased risk of Bladder carcinoma.
PIRP00001693	27323410	piR-34291	piR-hsa-26441	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-34291 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001694	27429044	hsa_piR_005076	piR-hsa-7327	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_005076 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001695	25305452	DQ600174	piR-hsa-30374	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ600174 may correlated with the increased risk of Bladder carcinoma.
PIRP00001696	25305452	DQ585901	piR-hsa-16151	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ585901 may correlated with the increased risk of Bladder carcinoma.
PIRP00001697	27893851	DQ592932	piR-hsa-23210	Osteoarthritis 	EFO:0002506	upregulation	decreased risk	osteoarthritis patients	N/A	N/A	LPS and TNF¦Á induced inflammatory	-0.2	The piRNAs dysregulation associated with Osteoarthritis  was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Osteoarthritis  was validated by RT-PCR. The validated results indicated that the upregulation of DQ592932 may correlated with the decreased risk of Osteoarthritis . Moreover, the molecular functions or physiological functions of DQ592932 involving in the pathologies of Osteoarthritis  are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of DQ592932 is possibly correlated with the decreased risk of Osteoarthritis .
PIRP00001697	27893851	DQ592932	piR-hsa-23210	Rheumatoid arthritis	EFO:0000685	upregulation	decreased risk	rheumatoid arthritis patients	N/A	N/A	LPS and TNF¦Á induced inflammatory	-0.2	The piRNAs dysregulation associated with Rheumatoid arthritis was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Rheumatoid arthritis was validated by RT-PCR. The validated results indicated that the upregulation of DQ592932 may correlated with the decreased risk of Rheumatoid arthritis. Moreover, the molecular functions or physiological functions of DQ592932 involving in the pathologies of Rheumatoid arthritis are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of DQ592932 is possibly correlated with the decreased risk of Rheumatoid arthritis.
PIRP00001698	25305452	DQ586986	piR-hsa-17292	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ586986 may correlated with the increased risk of Bladder carcinoma.
PIRP00001699	25305452	DQ596660	piR-hsa-26862	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596660 may correlated with the increased risk of Bladder carcinoma.
PIRP00001700	27323410	piR-62011	piR-hsa-26131	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-62011 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001701	25305452	DQ570392	piR-hsa-672	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ570392 may correlated with the increased risk of Bladder carcinoma.
PIRP00001702	25305452	DQ581096	piR-hsa-11425	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ581096 may correlated with the increased risk of Bladder carcinoma.
PIRP00001703	26071182	piR-57125	piR-hsa-20266	Clear cell renal cell carcinomas	EFO:0000349	downregulation	poor progonosis	clear cell renal cell carcinomas patients	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Clear cell renal cell carcinomas was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Clear cell renal cell carcinomas was validated by RT-PCR. The validated results indicated that the downregulation of piR-57125 may correlated with the poor progonosis of Clear cell renal cell carcinomas.
PIRP00001704	25305452	DQ570394	piR-hsa-674	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ570394 may correlated with the increased risk of Bladder carcinoma.
PIRP00001705	25305452	DQ598409	piR-hsa-28610	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ598409 may correlated with the increased risk of Bladder carcinoma.
PIRP00001706	25305452	DQ597622	piR-hsa-27867	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ597622 may correlated with the increased risk of Bladder carcinoma.
PIRP00001707	25305452	DQ593289	piR-hsa-23552	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ593289 may correlated with the increased risk of Bladder carcinoma.
PIRP00001708	28654860	piR-hsa-4300	piR-hsa-4300	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-4300 may correlated with the increased risk of Alzheimer's disease.
PIRP00001709	27893851	DQ592932	piR-hsa-23210	Osteoarthritis 	EFO:0002506	upregulation	decreased risk	osteoarthritis patients	N/A	N/A	LPS and TNF¦Á induced inflammatory	-0.2	The piRNAs dysregulation associated with Osteoarthritis  was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Osteoarthritis  was validated by RT-PCR. The validated results indicated that the upregulation of DQ592932 may correlated with the decreased risk of Osteoarthritis . Moreover, the molecular functions or physiological functions of DQ592932 involving in the pathologies of Osteoarthritis  are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of DQ592932 is possibly correlated with the decreased risk of Osteoarthritis .
PIRP00001709	27893851	DQ592932	piR-hsa-23210	Rheumatoid arthritis	EFO:0000685	upregulation	decreased risk	rheumatoid arthritis patients	N/A	N/A	LPS and TNF¦Á induced inflammatory	-0.2	The piRNAs dysregulation associated with Rheumatoid arthritis was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Rheumatoid arthritis was validated by RT-PCR. The validated results indicated that the upregulation of DQ592932 may correlated with the decreased risk of Rheumatoid arthritis. Moreover, the molecular functions or physiological functions of DQ592932 involving in the pathologies of Rheumatoid arthritis are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of DQ592932 is possibly correlated with the decreased risk of Rheumatoid arthritis.
PIRP00001710	25305452	DQ570392	piR-hsa-672	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ570392 may correlated with the increased risk of Bladder carcinoma.
PIRP00001711	25305452	DQ593538	piR-hsa-23786	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ593538 may correlated with the increased risk of Bladder carcinoma.
PIRP00001711	27429044	hsa_piR_017033	piR-hsa-23786	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_017033 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001712	25998508	piR-34434	piR-hsa-26584	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-34434 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001713	25305452	DQ570394	piR-hsa-674	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ570394 may correlated with the increased risk of Bladder carcinoma.
PIRP00001714	28423657	piR-35127	piR-hsa-27351	Breast carcinoma	EFO:0000305	downregulation	increased risk	breast cancer cell lines	N/A	N/A	AMPK signaling pathway	-0.05	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-35127 may correlated with the increased risk of Breast carcinoma.
PIRP00001715	23229900	piR-17458	piR-hsa-24360	Breast carcinoma	EFO:0000305	downregulation	increased risk	resected breast cancer cases	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-17458 may correlated with the increased risk of Breast carcinoma.
PIRP00001715	27323410	piR-60238	piR-hsa-24360	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-60238 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001716	28654860	piR-hsa-10106	piR-hsa-10106	Alzheimer's disease	EFO:0000249	downregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-hsa-10106 may correlated with the increased risk of Alzheimer's disease.
PIRP00001717	25305452	DQ596128	piR-hsa-26359	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596128 may correlated with the increased risk of Bladder carcinoma.
PIRP00001718	25305452	DQ596300	piR-hsa-26516	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ596300 may correlated with the increased risk of Bladder carcinoma.
PIRP00001719	27829231	DQ596354	piR-hsa-26570	Lung adenocarcinoma	EFO:0000571	upregulation	poor progonosis	lung adenocarcinoma samples	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Lung adenocarcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung adenocarcinoma was validated by RT-PCR. The validated results indicated that the upregulation of DQ596354 may correlated with the poor progonosis of Lung adenocarcinoma.
PIRP00001719	27829231	DQ596354	piR-hsa-26570	Squamous cell lung carcinoma	EFO:0000708	upregulation	poor progonosis	lung squamous cell carcinoma samples	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Squamous cell lung carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Squamous cell lung carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of DQ596354 may correlated with the poor progonosis of Squamous cell lung carcinoma.
PIRP00001720	28654860	piR-hsa-14148	piR-hsa-14148	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-14148 may correlated with the increased risk of Alzheimer's disease.
PIRP00001721	25305452	DQ593256	piR-hsa-23519	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ593256 may correlated with the increased risk of Bladder carcinoma.
PIRP00001722	25910082	piR-017061	piR-hsa-23822	Pancreatic carcinoma	EFO:0002618	downregulation	increased risk	pancreatic cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Pancreatic carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-017061 may correlated with the increased risk of Pancreatic carcinoma.
PIRP00001723	27323410	piR-35221	piR-hsa-27124	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-35221 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001724	29382334	piR-1245	piR-hsa-1963	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer patients	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-1245 may correlated with the increased risk of Bladder carcinoma.
PIRP00001725	25998508	piR-64616	piR-rno-50934	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-64616 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001726	28423657	piR-46545	piR-hsa-8674	Breast carcinoma	EFO:0000305	downregulation	increased risk	breast cancer cell lines	N/A	N/A	AMPK signaling pathway	-0.05	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-46545 may correlated with the increased risk of Breast carcinoma.
PIRP00001726	28423657	piR-46545	piR-hsa-8674	Lung carcinoma	EFO:0001071	downregulation	increased risk	lung cancer patients and lung cancer cell lines	N/A	AMPK	AMPK signaling pathway	-0.4	The piRNAs dysregulation associated with Lung carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Lung carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of piR-46545 may correlated with the increased risk of Lung carcinoma. Moreover, both molecular functions and physiological functions of piR-46545 involving in the pathologies of Lung carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the downregulation of piR-46545 is possibly correlated with the increased risk of Lung carcinoma.
PIRP00001727	25305452	DQ596918	piR-hsa-27208	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ596918 may correlated with the increased risk of Bladder carcinoma.
PIRP00001728	25305452	DQ592931	piR-hsa-23209	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ592931 may correlated with the increased risk of Bladder carcinoma.
PIRP00001728	27323410	piR-33043	piR-hsa-23209	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-33043 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001728	28109471	piR-33043	piR-hsa-23209	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-33043 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00001729	25305452	DQ601526	piR-hsa-31766	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ601526 may correlated with the increased risk of Bladder carcinoma.
PIRP00001729	27429044	hsa_piR_023057	piR-hsa-31766	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_023057 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001730	28423657	piR-34871	piR-hsa-27007	Breast carcinoma	EFO:0000305	upregulation	increased risk	breast cancer cell lines	N/A	N/A	AMPK signaling pathway	0.05	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-34871 may correlated with the increased risk of Breast carcinoma.
PIRP00001731	25305452	DQ578335	piR-hsa-8576	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ578335 may correlated with the increased risk of Bladder carcinoma.
PIRP00001732	25305452	DQ601527	piR-hsa-31767	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ601527 may correlated with the increased risk of Bladder carcinoma.
PIRP00001733	27323410	piR-33880	piR-hsa-24016	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-33880 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001734	25305452	DQ579146	piR-hsa-9444	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ579146 may correlated with the increased risk of Bladder carcinoma.
PIRP00001735	25305452	DQ574835	piR-hsa-5170	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ574835 may correlated with the increased risk of Bladder carcinoma.
PIRP00001736	28654860	piR-hsa-1963	piR-hsa-1963	Alzheimer's disease	EFO:0000249	downregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-hsa-1963 may correlated with the increased risk of Alzheimer's disease.
PIRP00001737	27323410	piR-31355	piR-hsa-1580	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-31355 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001738	25305452	DQ588525	piR-hsa-18837	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ588525 may correlated with the increased risk of Bladder carcinoma.
PIRP00001739	25305452	DQ581701	piR-hsa-11955	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ581701 may correlated with the increased risk of Bladder carcinoma.
PIRP00001740	25305452	DQ575105	piR-hsa-5411	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ575105 may correlated with the increased risk of Bladder carcinoma.
PIRP00001741	28654860	piR-hsa-27438	piR-hsa-27438	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-27438 may correlated with the increased risk of Alzheimer's disease.
PIRP00001742	28654860	piR-hsa-11726	piR-hsa-11726	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-11726 may correlated with the increased risk of Alzheimer's disease.
PIRP00001743	25305452	DQ574109	piR-hsa-4371	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ574109 may correlated with the increased risk of Bladder carcinoma.
PIRP00001744	25305452	DQ585901	piR-hsa-16151	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ585901 may correlated with the increased risk of Bladder carcinoma.
PIRP00001745	25305452	DQ571055	piR-hsa-1306	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ571055 may correlated with the increased risk of Bladder carcinoma.
PIRP00001746	28654860	piR-hsa-28243	piR-hsa-28243	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-28243 may correlated with the increased risk of Alzheimer's disease.
PIRP00001747	25998508	piR-32985	piR-hsa-13196	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-32985 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001748	23112866	DQ591415	piR-hsa-32	Sertoli cell-only syndrome	EFO:1001422	downregulation	increased risk	sertoli cell-only syndrome and spermatogenic failure patients	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Sertoli cell-only syndrome was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Sertoli cell-only syndrome was validated by RT-PCR. The validated results indicated that the downregulation of DQ591415 may correlated with the increased risk of Sertoli cell-only syndrome.
PIRP00001749	25998508	piR-32986	piR-hsa-13197	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-32986 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001750	25305452	DQ593618	piR-hsa-23866	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ593618 may correlated with the increased risk of Bladder carcinoma.
PIRP00001751	27429044	hsa_piR_019420	piR-hsa-26872	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_019420 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001752	25305452	DQ597622	piR-hsa-27867	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ597622 may correlated with the increased risk of Bladder carcinoma.
PIRP00001753	25305452	DQ593289	piR-hsa-23552	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ593289 may correlated with the increased risk of Bladder carcinoma.
PIRP00001754	27323410	piR-35466	piR-hsa-27137	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-35466 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00001755	25305452	DQ593621	piR-hsa-23869	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ593621 may correlated with the increased risk of Bladder carcinoma.
PIRP00001756	27323410	piR-35467	piR-hsa-27138	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-35467 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00001757	29516567	piR-52205	piR-hsa-15404	Neuroblastoma	EFO:0000621	upregulation	increased risk	neuroblastoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Neuroblastoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-52205 may correlated with the increased risk of Neuroblastoma.
PIRP00001758	25305452	DQ598548	piR-hsa-28749	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ598548 may correlated with the increased risk of Bladder carcinoma.
PIRP00001759	27323410	piR-35468	piR-hsa-27139	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-35468 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00001760	29516567	piR-52206	piR-hsa-15405	Neuroblastoma	EFO:0000621	upregulation	increased risk	neuroblastoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Neuroblastoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-52206 may correlated with the increased risk of Neuroblastoma.
PIRP00001761	25779424	FR222326	FR222326	Gastric carcinoma	EFO:0000178	upregulation	poor progonosis	gastric cancer recurrence	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Gastric carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of FR222326 may correlated with the poor progonosis of Gastric carcinoma.
PIRP00001762	26071182	piR-38756	piR-hsa-30978	Clear cell renal cell carcinomas	EFO:0000349	upregulation	poor progonosis	clear cell renal cell carcinomas patients	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Clear cell renal cell carcinomas was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Clear cell renal cell carcinomas was validated by RT-PCR. The validated results indicated that the upregulation of piR-38756 may correlated with the poor progonosis of Clear cell renal cell carcinomas.
PIRP00001763	28654860	piR-hsa-30217	piR-hsa-30217	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-30217 may correlated with the increased risk of Alzheimer's disease.
PIRP00001764	25305452	DQ584635	piR-hsa-14960	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ584635 may correlated with the increased risk of Bladder carcinoma.
PIRP00001765	25313140	DQ598183	piR-hsa-28398	Breast carcinoma	EFO:0000305	downregulation	increased risk	breast cancer	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of DQ598183 may correlated with the increased risk of Breast carcinoma.
PIRP00001766	25305452	DQ593256	piR-hsa-23519	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ593256 may correlated with the increased risk of Bladder carcinoma.
PIRP00001767	25740697	piR-015551	piR-hsa-21517	Colorectal cancer	EFO:0005842	rs11776042	decreased risk	colorectal cancer 	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Colorectal cancer was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Colorectal cancer was validated by RT-PCR. The validated results indicated that the rs11776042 of piR-015551 may correlated with the decreased risk of Colorectal cancer.
PIRP00001768	25305452	DQ584405	piR-hsa-14730	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ584405 may correlated with the increased risk of Bladder carcinoma.
PIRP00001769	27429044	hsa_piR_019168	piR-hsa-26527	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_019168 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001770	27323410	piR-36241	piR-hsa-28390	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36241 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001771	25998508	piR-43607	piR-hsa-5773	Renal cell carcinoma	EFO:0000681	upregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	0.20	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Renal cell carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-43607 may correlated with the increased risk and poor progonosis of Renal cell carcinoma. Moreover, the molecular functions or physiological functions of piR-43607 involving in the pathologies of Renal cell carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-43607 is possibly correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001772	25998508	piR-54542	piR-hsa-17720	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-54542 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001773	25305452	DQ570215	piR-hsa-524	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ570215 may correlated with the increased risk of Bladder carcinoma.
PIRP00001774	25305452	DQ596918	piR-hsa-27208	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ596918 may correlated with the increased risk of Bladder carcinoma.
PIRP00001775	25305452	DQ580466	piR-hsa-10692	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ580466 may correlated with the increased risk of Bladder carcinoma.
PIRP00001776	25305452	DQ592931	piR-hsa-23209	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ592931 may correlated with the increased risk of Bladder carcinoma.
PIRP00001777	27068805	piR-43771	piR-hsa-5937	Azoospermia	EFO:0000279	downregulation	increased risk	seminal plasma of infertile patients	N/A	N/A	N/A	-0.2	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of piR-43771 may correlated with the increased risk of Azoospermia. Moreover, the molecular functions or physiological functions of piR-43771 involving in the pathologies of Azoospermia are illustrated in cell lines in vitro. Altogether, all above results suggested that the downregulation of piR-43771 is possibly correlated with the increased risk of Azoospermia.
PIRP00001778	25305452	DQ572459	piR-hsa-2695	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ572459 may correlated with the increased risk of Bladder carcinoma.
PIRP00001779	27323410	piR-36245	piR-hsa-28394	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36245 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001779	28109471	piR-36245	piR-hsa-28394	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36245 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00001780	25305452	DQ601526	piR-hsa-31766	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ601526 may correlated with the increased risk of Bladder carcinoma.
PIRP00001781	27068805	piR-43773	piR-hsa-5939	Azoospermia	EFO:0000279	downregulation	increased risk	seminal plasma of infertile patients	N/A	N/A	N/A	-0.2	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of piR-43773 may correlated with the increased risk of Azoospermia. Moreover, the molecular functions or physiological functions of piR-43773 involving in the pathologies of Azoospermia are illustrated in cell lines in vitro. Altogether, all above results suggested that the downregulation of piR-43773 is possibly correlated with the increased risk of Azoospermia.
PIRP00001782	27323410	piR-36246	piR-hsa-28395	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36246 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001783	28654860	piR-hsa-27398	piR-hsa-27398	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-27398 may correlated with the increased risk of Alzheimer's disease.
PIRP00001784	25305452	DQ579020	piR-hsa-9332	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ579020 may correlated with the increased risk of Bladder carcinoma.
PIRP00001785	25305452	DQ601527	piR-hsa-31767	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ601527 may correlated with the increased risk of Bladder carcinoma.
PIRP00001786	28654860	piR-hsa-27399	piR-hsa-27399	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-27399 may correlated with the increased risk of Alzheimer's disease.
PIRP00001787	28654860	piR-hsa-1963	piR-hsa-1963	Alzheimer's disease	EFO:0000249	downregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-hsa-1963 may correlated with the increased risk of Alzheimer's disease.
PIRP00001788	25305452	DQ585211	piR-hsa-15522	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ585211 may correlated with the increased risk of Bladder carcinoma.
PIRP00001789	26148798	DQ597347	piR-hsa-27622	Asthma	EFO:0000270	upregulation	increased risk	asthmatic patientss	N/A	N/A	Akt signaling pathway	0.10	The piRNAs dysregulation associated with Asthma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Asthma was validated by RT-PCR. The validated results indicated that the upregulation of DQ597347 may correlated with the increased risk of Asthma.
PIRP00001790	28654860	piR-hsa-16724	piR-hsa-16724	Alzheimer's disease	EFO:0000249	downregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-hsa-16724 may correlated with the increased risk of Alzheimer's disease.
PIRP00001791	27429044	hsa_piR_003728	piR-hsa-5370	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_003728 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001792	28654860	piR-hsa-14119	piR-hsa-14119	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-14119 may correlated with the increased risk of Alzheimer's disease.
PIRP00001793	27323410	piR-54907	piR-hsa-18071	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-54907 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001794	27323410	piR-36338	piR-hsa-28487	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36338 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001795	25305452	DQ576153	piR-hsa-6416	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ576153 may correlated with the increased risk of Bladder carcinoma.
PIRP00001796	25305452	DQ571328	piR-hsa-1331	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ571328 may correlated with the increased risk of Bladder carcinoma.
PIRP00001797	27323410	piR-43992	piR-hsa-6143	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-43992 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001798	27323410	piR-36340	piR-hsa-28489	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36340 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001799	27429044	hsa_piR_020009	piR-hsa-27730	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_020009 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001800	27323410	piR-43995	piR-hsa-6146	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-43995 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001801	25305452	DQ582426	piR-hsa-12649	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ582426 may correlated with the increased risk of Bladder carcinoma.
PIRP00001802	27068805	piR-30198	piR-hsa-395	Azoospermia	EFO:0000279	downregulation	increased risk	seminal plasma of infertile patients	N/A	N/A	N/A	-0.2	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of piR-30198 may correlated with the increased risk of Azoospermia. Moreover, the molecular functions or physiological functions of piR-30198 involving in the pathologies of Azoospermia are illustrated in cell lines in vitro. Altogether, all above results suggested that the downregulation of piR-30198 is possibly correlated with the increased risk of Azoospermia.
PIRP00001803	27323410	piR-33510	piR-hsa-22905	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-33510 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001804	25305452	DQ587911	piR-hsa-18158	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ587911 may correlated with the increased risk of Bladder carcinoma.
PIRP00001805	25305452	DQ574685	piR-hsa-5020	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ574685 may correlated with the increased risk of Bladder carcinoma.
PIRP00001806	27323410	piR-43996	piR-hsa-6147	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-43996 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001806	27429044	hsa_piR_004309	piR-hsa-6147	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_004309 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001807	25305452	DQ595212	piR-hsa-25473	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ595212 may correlated with the increased risk of Bladder carcinoma.
PIRP00001808	23376363	piR-Hep1	piR-hsa-8438265	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	hepatocellular carcinoma patients and  hepatocellular lines	N/A	Akt	Akt signaling pathway	0.40	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Hepatocellular carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-Hep1 may correlated with the increased risk of Hepatocellular carcinoma. Moreover, both molecular functions and physiological functions of piR-Hep1 involving in the pathologies of Hepatocellular carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-Hep1 is possibly correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001809	29460056	DQ576492	piR-hsa-6740	Azoospermia	EFO:0000279	downregulation	increased risk	patients with nonobstructive azoospermia (NOA) between successful and unsuccessful sperm retrieval before micro-dissection testicular sperm extraction (micro-TESE)	N/A	N/A	Cell apoptosis, cell proliferation, and cell differentiation	-0.1	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of DQ576492 may correlated with the increased risk of Azoospermia.
PIRP00001810	27068805	piR-43771	piR-hsa-5937	Azoospermia	EFO:0000279	downregulation	increased risk	seminal plasma of infertile patients	N/A	N/A	N/A	-0.2	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of piR-43771 may correlated with the increased risk of Azoospermia. Moreover, the molecular functions or physiological functions of piR-43771 involving in the pathologies of Azoospermia are illustrated in cell lines in vitro. Altogether, all above results suggested that the downregulation of piR-43771 is possibly correlated with the increased risk of Azoospermia.
PIRP00001811	27429044	hsa_piR_001042	piR-hsa-1338	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_001042 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001812	26071182	piR-57125	piR-hsa-20266	Clear cell renal cell carcinomas	EFO:0000349	downregulation	poor progonosis	clear cell renal cell carcinomas patients	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Clear cell renal cell carcinomas was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Clear cell renal cell carcinomas was validated by RT-PCR. The validated results indicated that the downregulation of piR-57125 may correlated with the poor progonosis of Clear cell renal cell carcinomas.
PIRP00001813	26148798	DQ597484	piR-hsa-27730	Asthma	EFO:0000270	upregulation	increased risk	asthmatic patientss	N/A	N/A	Akt signaling pathway	0.10	The piRNAs dysregulation associated with Asthma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Asthma was validated by RT-PCR. The validated results indicated that the upregulation of DQ597484 may correlated with the increased risk of Asthma.
PIRP00001814	27068805	piR-43773	piR-hsa-5939	Azoospermia	EFO:0000279	downregulation	increased risk	seminal plasma of infertile patients	N/A	N/A	N/A	-0.2	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of piR-43773 may correlated with the increased risk of Azoospermia. Moreover, the molecular functions or physiological functions of piR-43773 involving in the pathologies of Azoospermia are illustrated in cell lines in vitro. Altogether, all above results suggested that the downregulation of piR-43773 is possibly correlated with the increased risk of Azoospermia.
PIRP00001815	27323410	piR-30456	piR-hsa-624	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-30456 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001815	27429044	hsa_piR_000291	piR-hsa-624	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_000291 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001816	28654860	piR-hsa-28390	piR-hsa-28390	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-28390 may correlated with the increased risk of Alzheimer's disease.
PIRP00001817	27429044	hsa_piR_017724	piR-hsa-24684	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_017724 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001818	28654860	piR-hsa-2038	piR-hsa-2038	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-2038 may correlated with the increased risk of Alzheimer's disease.
PIRP00001819	29460056	DQ576170	piR-hsa-6433	Azoospermia	EFO:0000279	downregulation	increased risk	patients with nonobstructive azoospermia (NOA) between successful and unsuccessful sperm retrieval before micro-dissection testicular sperm extraction (micro-TESE)	N/A	N/A	Cell apoptosis, cell proliferation, and cell differentiation	-0.1	The piRNAs dysregulation associated with Azoospermia was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Azoospermia was validated by RT-PCR. The validated results indicated that the downregulation of DQ576170 may correlated with the increased risk of Azoospermia.
PIRP00001820	25305452	DQ589977	piR-hsa-20230	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ589977 may correlated with the increased risk of Bladder carcinoma.
PIRP00001821	25305452	DQ587714	piR-hsa-17990	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ587714 may correlated with the increased risk of Bladder carcinoma.
PIRP00001822	25305452	DQ584405	piR-hsa-14730	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ584405 may correlated with the increased risk of Bladder carcinoma.
PIRP00001823	25305452	DQ590020	piR-hsa-20273	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ590020 may correlated with the increased risk of Bladder carcinoma.
PIRP00001824	28654860	piR-hsa-19112	piR-hsa-19112	Alzheimer's disease	EFO:0000249	downregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-hsa-19112 may correlated with the increased risk of Alzheimer's disease.
PIRP00001825	27429044	hsa_piR_016664	piR-hsa-23216	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_016664 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001826	25305452	DQ601720	piR-hsa-31944	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ601720 may correlated with the increased risk of Bladder carcinoma.
PIRP00001827	25305452	DQ594040	piR-hsa-24274	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ594040 may correlated with the increased risk of Bladder carcinoma.
PIRP00001827	25305452	DQ594040	piR-hsa-24274	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	TNFSF4	Cell proliferation and apoptosis 	-0.4	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Bladder carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of DQ594040 may correlated with the increased risk of Bladder carcinoma. Moreover, both molecular functions and physiological functions of DQ594040 involving in the pathologies of Bladder carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the downregulation of DQ594040 is possibly correlated with the increased risk of Bladder carcinoma.
PIRP00001828	27323410	piR-34736	piR-hsa-26872	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	EMT signaling pathway and cell apoptosis 	0.20	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Head and neck squamous cell carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-34736 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma. Moreover, the molecular functions or physiological functions of piR-34736 involving in the pathologies of Head and neck squamous cell carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-34736 is possibly correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00001829	27323410	piR-37523	piR-hsa-29714	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-37523 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001830	25305452	DQ589140	piR-hsa-19422	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ589140 may correlated with the increased risk of Bladder carcinoma.
PIRP00001831	27323410	piR-37524	piR-hsa-29715	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-37524 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001832	27323410	piR-37525	piR-hsa-29716	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-37525 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001833	25305452	DQ576844	piR-hsa-7180	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ576844 may correlated with the increased risk of Bladder carcinoma.
PIRP00001834	25305452	DQ577614	piR-hsa-6917	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ577614 may correlated with the increased risk of Bladder carcinoma.
PIRP00001835	25305452	DQ587024	piR-hsa-17330	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ587024 may correlated with the increased risk of Bladder carcinoma.
PIRP00001836	25305452	DQ572051	piR-hsa-2331	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ572051 may correlated with the increased risk of Bladder carcinoma.
PIRP00001837	27323410	piR-61298	piR-hsa-25447	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-61298 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001838	25998508	piR-32105	piR-hsa-12232	Renal cell carcinoma	EFO:0000681	upregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-32105 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001839	25910082	piR-017061	piR-hsa-23822	Pancreatic carcinoma	EFO:0002618	downregulation	increased risk	pancreatic cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Pancreatic carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-017061 may correlated with the increased risk of Pancreatic carcinoma.
PIRP00001839	27429044	hsa_piR_017061	piR-hsa-23822	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_017061 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001840	25305452	DQ593618	piR-hsa-23866	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ593618 may correlated with the increased risk of Bladder carcinoma.
PIRP00001841	25305452	DQ587911	piR-hsa-18158	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ587911 may correlated with the increased risk of Bladder carcinoma.
PIRP00001842	27429044	hsa_piR_020828	piR-hsa-28875	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_020828 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001843	25305452	DQ580256	piR-hsa-10496	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ580256 may correlated with the increased risk of Bladder carcinoma.
PIRP00001844	25305452	DQ597622	piR-hsa-27867	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ597622 may correlated with the increased risk of Bladder carcinoma.
PIRP00001845	25305452	DQ593289	piR-hsa-23552	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ593289 may correlated with the increased risk of Bladder carcinoma.
PIRP00001846	27429044	hsa_piR_020829	piR-hsa-28877	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_020829 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001847	28651359	DQ571823	piR-hsa-2117	Diminished ovarian reserve	EFO:0004770	upregulation	increased risk	patients with diminished ovarian reserve	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Diminished ovarian reserve was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ571823 may correlated with the increased risk of Diminished ovarian reserve.
PIRP00001848	27323410	piR-45029	piR-hsa-7238	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-45029 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001849	25305452	DQ593621	piR-hsa-23869	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ593621 may correlated with the increased risk of Bladder carcinoma.
PIRP00001850	27429044	hsa_piR_020809	piR-hsa-28839	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_020809 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001851	27429044	hsa_piR_007336	piR-hsa-10246	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_007336 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001852	23229900	piR-20365	piR-hsa-28190	Breast carcinoma	EFO:0000305	upregulation	increased risk	resected breast cancer cases	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-20365 may correlated with the increased risk of Breast carcinoma.
PIRP00001852	27323410	piR-36041	piR-hsa-28190	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36041 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001852	27429044	hsa_piR_020365	piR-hsa-28190	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_020365 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001853	28654860	piR-hsa-2038	piR-hsa-2038	Alzheimer's disease	EFO:0000249	upregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-hsa-2038 may correlated with the increased risk of Alzheimer's disease.
PIRP00001854	25313140	DQ598252	piR-hsa-28467	Breast carcinoma	EFO:0000305	downregulation	increased risk	breast cancer	N/A	N/A	N/A	-0.1	The piRNAs dysregulation associated with Breast carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Breast carcinoma was validated by RT-PCR. The validated results indicated that the downregulation of DQ598252 may correlated with the increased risk of Breast carcinoma.
PIRP00001854	25998508	piR-36318	piR-hsa-28467	Renal cell carcinoma	EFO:0000681	upregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36318 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001854	27323410	piR-36318	piR-hsa-28467	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-36318 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001855	25305452	DQ593256	piR-hsa-23519	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ593256 may correlated with the increased risk of Bladder carcinoma.
PIRP00001856	25305452	DQ590181	piR-hsa-20405	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ590181 may correlated with the increased risk of Bladder carcinoma.
PIRP00001857	29382334	piR-1245	piR-hsa-1963	Pancreatic carcinoma	EFO:0002618	upregulation	increased risk	prostate cancer patients	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Pancreatic carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-1245 may correlated with the increased risk of Pancreatic carcinoma.
PIRP00001858	25305452	DQ582387	piR-hsa-12610	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ582387 may correlated with the increased risk of Bladder carcinoma.
PIRP00001859	25305452	DQ596854	piR-hsa-27056	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ596854 may correlated with the increased risk of Bladder carcinoma.
PIRP00001860	25305452	DQ596918	piR-hsa-27208	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ596918 may correlated with the increased risk of Bladder carcinoma.
PIRP00001861	25305452	DQ592931	piR-hsa-23209	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ592931 may correlated with the increased risk of Bladder carcinoma.
PIRP00001861	27323410	piR-33043	piR-hsa-23209	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-33043 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001861	28109471	piR-33043	piR-hsa-23209	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk and poor progonosis	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-33043 may correlated with the increased risk and poor progonosis of Head and neck squamous cell carcinoma.
PIRP00001862	27429044	hsa_piR_020305	piR-hsa-28117	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_020305 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001863	25998508	piR-45808	piR-hsa-7955	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-45808 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001864	25998508	piR-54403	piR-hsa-17582	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-54403 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001865	25998508	piR-45809	piR-hsa-7956	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-45809 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001866	25305452	DQ601526	piR-hsa-31766	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ601526 may correlated with the increased risk of Bladder carcinoma.
PIRP00001866	27429044	hsa_piR_023057	piR-hsa-31766	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_023057 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001867	25305452	DQ601527	piR-hsa-31767	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ601527 may correlated with the increased risk of Bladder carcinoma.
PIRP00001868	25305452	DQ589140	piR-hsa-19422	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ589140 may correlated with the increased risk of Bladder carcinoma.
PIRP00001869	25305452	DQ577740	piR-hsa-7999	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ577740 may correlated with the increased risk of Bladder carcinoma.
PIRP00001870	25305452	DQ570999	piR-hsa-1250	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ570999 may correlated with the increased risk of Bladder carcinoma.
PIRP00001871	25305452	DQ571000	piR-hsa-1251	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ571000 may correlated with the increased risk of Bladder carcinoma.
PIRP00001872	28654860	piR-hsa-28908	piR-hsa-28908	Alzheimer's disease	EFO:0000249	downregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-hsa-28908 may correlated with the increased risk of Alzheimer's disease.
PIRP00001873	27429044	hsa_piR_001170	piR-hsa-1849	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of hsa_piR_001170 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001874	27323410	piR-35221	piR-hsa-27124	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-35221 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001875	25305452	DQ600938	piR-hsa-31224	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ600938 may correlated with the increased risk of Bladder carcinoma.
PIRP00001876	23376363	piR-Hep1	piR-hsa-8438265	Hepatocellular carcinoma	EFO:0000182	upregulation	increased risk	hepatocellular carcinoma patients and  hepatocellular lines	N/A	Akt	Akt signaling pathway	0.40	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Hepatocellular carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-Hep1 may correlated with the increased risk of Hepatocellular carcinoma. Moreover, both molecular functions and physiological functions of piR-Hep1 involving in the pathologies of Hepatocellular carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-Hep1 is possibly correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001877	25305452	DQ570901	piR-hsa-1152	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ570901 may correlated with the increased risk of Bladder carcinoma.
PIRP00001878	27323410	piR-33044	piR-hsa-23210	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-33044 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001879	27429044	hsa_piR_011901	piR-hsa-16348	Hepatocellular carcinoma	EFO:0000182	downregulation	increased risk	Hepatocellular carcinoma_vs_Cirrhosis	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Hepatocellular carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of hsa_piR_011901 may correlated with the increased risk of Hepatocellular carcinoma.
PIRP00001880	25305452	DQ581440	piR-hsa-11725	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ581440 may correlated with the increased risk of Bladder carcinoma.
PIRP00001881	25998508	piR-39894	piR-hsa-32052	Renal cell carcinoma	EFO:0000681	upregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	0.20	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Renal cell carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-39894 may correlated with the increased risk and poor progonosis of Renal cell carcinoma. Moreover, the molecular functions or physiological functions of piR-39894 involving in the pathologies of Renal cell carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-39894 is possibly correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001882	25305452	DQ574993	piR-hsa-5299	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ574993 may correlated with the increased risk of Bladder carcinoma.
PIRP00001883	28654860	piR-hsa-27248	piR-hsa-27248	Alzheimer's disease	EFO:0000249	downregulation	increased risk	Alzheimer's disease	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Alzheimer's disease was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-hsa-27248 may correlated with the increased risk of Alzheimer's disease.
PIRP00001884	25998508	piR-32985	piR-hsa-13196	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-32985 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001885	25305452	DQ593739	piR-hsa-23987	Bladder carcinoma	EFO:0000292	downregulation	increased risk	bladder cancer	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of DQ593739 may correlated with the increased risk of Bladder carcinoma.
PIRP00001886	24732595	piR-823	piR-hsa-1282	Multiple myeloma	EFO:0001378	upregulation	increased risk and poor progonosis	multiple myeloma patients and multiple myeloma cell lines	N/A	DNMT3A and 3B	Cell proliferation, cell apoptosis, cell cycle and angiogenesis	0.80	The piRNAs dysregulation associated with Multiple myeloma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Multiple myeloma was validated by RT-PCR. The validated results indicated that the upregulation of piR-823 may correlated with the increased risk and poor progonosis of Multiple myeloma. Moreover, both molecular functions, physiological functions and/or mechanisms of piR-823 involving in the pathologies of Multiple myeloma are illustrated in cell lines in vitro. Furthermore, the animal model experiments in vivo (eg. xenograft, transgenic) also demonstrated and supported the piR-823 dysregulation associated with the pathologies of Multiple myeloma. Altogether, all above results suggested that the upregulation of piR-823 is possibly correlated with the increased risk and poor progonosis of Multiple myeloma.
PIRP00001887	25779424	FR387750	FR387750	Gastric carcinoma	EFO:0000178	upregulation	poor progonosis	gastric cancer recurrence	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Gastric carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of FR387750 may correlated with the poor progonosis of Gastric carcinoma.
PIRP00001888	25305452	DQ596690	piR-hsa-26892	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ596690 may correlated with the increased risk of Bladder carcinoma.
PIRP00001889	25998508	piR-32986	piR-hsa-13197	Renal cell carcinoma	EFO:0000681	downregulation	increased risk and poor progonosis	renal cell carcinoma 	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Renal cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-32986 may correlated with the increased risk and poor progonosis of Renal cell carcinoma.
PIRP00001890	25779424	FR387750	FR387750	Gastric carcinoma	EFO:0000178	upregulation	poor progonosis	gastric cancer recurrence	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Gastric carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of FR387750 may correlated with the poor progonosis of Gastric carcinoma.
PIRP00001891	28651359	DQ576780	piR-hsa-7116	Diminished ovarian reserve	EFO:0004770	upregulation	increased risk	patients with diminished ovarian reserve	N/A	N/A	N/A	0.10	The piRNAs dysregulation associated with Diminished ovarian reserve was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Diminished ovarian reserve was validated by RT-PCR. The validated results indicated that the upregulation of DQ576780 may correlated with the increased risk of Diminished ovarian reserve.
PIRP00001892	27414029	piR-651	piR-hsa-1077	Pancreatic carcinoma	EFO:0002618	upregulation	decreased risk	prostate cancer cell lines	hormone treatment	N/A	Cell proliferation and EMT signaling pathway	-0.2	The piRNAs dysregulation associated with Pancreatic carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. And then the screened piRNAs dysregulation associated with Pancreatic carcinoma was validated by RT-PCR. The validated results indicated that the upregulation of piR-651 may correlated with the decreased risk of Pancreatic carcinoma. Moreover, the molecular functions or physiological functions of piR-651 involving in the pathologies of Pancreatic carcinoma are illustrated in cell lines in vitro. Altogether, all above results suggested that the upregulation of piR-651 is possibly correlated with the decreased risk of Pancreatic carcinoma.
PIRP00001893	25305452	DQ590027	piR-hsa-20280	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ590027 may correlated with the increased risk of Bladder carcinoma.
PIRP00001894	25305452	DQ599457	piR-hsa-29714	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ599457 may correlated with the increased risk of Bladder carcinoma.
PIRP00001894	27323410	piR-37523	piR-hsa-29714	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-37523 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001895	25305452	DQ595179	piR-hsa-25440	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ595179 may correlated with the increased risk of Bladder carcinoma.
PIRP00001896	25305452	DQ590028	piR-hsa-20281	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ590028 may correlated with the increased risk of Bladder carcinoma.
PIRP00001897	25305452	DQ599458	piR-hsa-29715	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ599458 may correlated with the increased risk of Bladder carcinoma.
PIRP00001897	27323410	piR-37524	piR-hsa-29715	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-37524 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001898	27323410	piR-30840	piR-hsa-993	Head and neck squamous cell carcinoma	EFO:0000181	downregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	-0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the downregulation of piR-30840 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001899	25305452	DQ590029	piR-hsa-20282	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ590029 may correlated with the increased risk of Bladder carcinoma.
PIRP00001900	25305452	DQ599459	piR-hsa-29716	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ599459 may correlated with the increased risk of Bladder carcinoma.
PIRP00001900	27323410	piR-37525	piR-hsa-29716	Head and neck squamous cell carcinoma	EFO:0000181	upregulation	increased risk	head and neck squamous cell carcinoma	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Head and neck squamous cell carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of piR-37525 may correlated with the increased risk of Head and neck squamous cell carcinoma.
PIRP00001901	25305452	DQ590030	piR-hsa-20283	Bladder carcinoma	EFO:0000292	upregulation	increased risk	bladder cancer	N/A	N/A	N/A	0.05	The piRNAs dysregulation associated with Bladder carcinoma was screened by high throughput technologies such as next generation sequencing or microarray. The screened results indicated that the upregulation of DQ590030 may correlated with the increased risk of Bladder carcinoma.